Radiochemical study on effective nuclide probes localized in nasal cavity and tumor tissues, and given high energy transfer on site

• Project/Area Number: 23550072
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Inorganic chemistry
• Research Institution: Kanazawa University
• Principal Investigator: AMANO Ryohei 金沢大学, 保健学系, 教授 (30111769)
• Co-Investigator(Kenkyū-buntansha): WASHIYAMA Kohshin 金沢大学, 保健学系, 助教 (80313675) ; MIYATI Toshiaki 金沢大学, 保健学系, 教授 (80324086) ; SHIGA Hideaki 金沢医科大学, 医学部, 准教授 (80436823)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 高ＬＥＴ核種 / 壊変系列 / アルファ核種 / 内部被ばく線量 / エネルギー付与 / 鼻腔 / 腫瘍 / 線エネルギー付与 / 壊変エネルギー / 高LET核種 / 動物実験

Outline of Final Research Achievements

To assess a radiation energy trannsfer to olfactory bulb from 201Tl localized in nasal cavity, a new site informatic index of nasal cavity and right/left olfactory bulb was given on a digital phantom, Digimouse, to use Monte Carlo simulation for MIRD internal dose computation. And to compare the energy transfers to tumor tissue by alpha-rays emitted among various heavy nuclides and their chemicals localized at the same place, 227Th and 223Ra in the actinium series, and 225Ac in the neptunium series were focused in terms of labeling procedure of their compounds, and observation of localizing in tumor tissue, were discussed by compareing the isotopes(equal Z nuclides) in uranium series and thorium series.

Research Products

• [Journal Article] Assessment of Olfactory Nerve by SPECT-MRI Image with Nasal Thallium-201 Administration in Patients with Olfactory Impairments in Comparison to Healthy Volunteers (2013)
  • Author(s): H Shiga, J Taki, K Washiyama, J Yamamoto, S Kinase, K Okuda, S Kinuya, N Watanabe, H Tonami, K Koshida, R Amano, M Furukawa, T Miwa
  • Journal Title: Plos one, journal.pone.0029265 Volume: 8 Pages: 1-8
  • NAID: 120005253903
  • Peer Reviewed
• [Journal Article] Biological Safety of Nasal Thallium-201 Administration: A Preclinical Study for Olfacto-scintigraphy (2011)
  • Author(s): Washiyama, K., Shiga, H., Hirota, K.
  • Journal Title: Journal of Radiation Research Volume: 52 Issue: 4 Pages: 450-455
  • DOI: 10.1269/jrr.10153
  • NAID: 10029122142
  • ISSN: 0449-3060, 1349-9157
  • Peer Reviewed
• [Presentation] Development of a 211Rn/211At generator using a wet chemistry approach for targeted alpha therapy applications (2015)
  • Author(s): K. Washiyama, R. Amano, E. Maeda, N. Yamada, T. Taniguchi, A. Yokoyama, I. Nishinaka, A. Toyoshima, H. Makii, K. Hashimoto
  • Organizer: 9th Symposium on Targeted Alpha Therapy
  • Place of Presentation: Palac Prymasowski, Warsaw Poland
  • Year and Date: 2015-05-20 – 2015-05-21
• [Presentation] Evaluation and Optimization of Direct Radioiodination of an ε-Lysyl-3-(Trimethylstannyl)Benzamide Immunoconjugates (2014)
  • Author(s): Kohshin Washiyama, Sture Lindegren, Yuriko Hiramatsu, Emma Aneheim, and Ryohei Amano
  • Organizer: 27th Annual Congress of the European Association of Nuclear Medicine (EANM’14)
  • Place of Presentation: Svenska Massan, Gothenburg, Sweden
  • Year and Date: 2014-10-18 – 2014-10-22