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The development of a method for determining rapidly the abuse of gateway drugs, such as slimming drugs and cannabis

Research Project

Project/Area Number 23590055
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Physical pharmacy
Research InstitutionHoshi University

Principal Investigator

SAITO KOICHI  星薬科大学, 薬学部, 教授 (40386347)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords法科学 / 大麻 / 脱法ハーブ / 痩身薬 / ゲートウェイドラッグ / スクリーニング / 分析法 / 固相分散抽出法 / 鎮痛薬 / 薬物乱用 / 生体試料 / LC/TOF-MS / 国際情報交流
Research Abstract

A chiral analytical method of alfa-lipoic acid, a kind of slimming drugs, was constructed using LC-TOFMS. The method made it possible to determine the display violations of dietary preparations and supplements for slimming purposes.
A rapid screening method of synthetic cannabinoids and cathinones in illegal herbal products was constructed by using DART-TOF-MS. This method was also able to discriminate between synthetic cannabinoids and cannabis plant.
30 kinds of analgesics and adjuvant analgesics were selected as medical drugs, capable of causing abuse, and the analytical method of the drugs was constructed by using LC/TOF-MS.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (28 results)

All 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (12 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Development of a closed drug preparation method for oral anticancer drugs2013

    • Author(s)
      Nobuyuki Wakui, Tetuo Ookubo, Yusuke Iwasaki, Rie Ito, Koichi Saito and Hiroyuki Nakazawa
    • Journal Title

      Journal of Oncology Pharmacy Practice

      Volume: 未確定 Issue: 4 Pages: 315-320

    • DOI

      10.1177/1078155212467554

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] クロマトグラフィー/質量分析法による健康食品中のα-リポ酸の光学異性体の定量分析2012

    • Author(s)
      小林由幸、斉藤貢一、岩崎雄介、伊藤里恵
    • Journal Title

      分析化学

      Volume: 61(2) Pages: 109-114

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] リアルタイム直接分析(DART)-TOF-MSを用いる合成カンナビノイド系及び合成カチノン系薬物の迅速スクリーニング法2012

    • Author(s)
      樋口美代子、斉藤貢一
    • Journal Title

      分析化学

      Volume: 61(8) Pages: 705-711

    • NAID

      10030495342

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] リアルタイム直接分析(DART)-TOF-MS を用いる合成カンナビノイド系及び合成カチノン系薬物の迅速スクリーニング法2012

    • Author(s)
      樋口美代子,斉藤貢一
    • Journal Title

      分析化学

      Volume: 61 Pages: 705-711

    • NAID

      10030495342

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Discrimination of Cassia Plants in Health Tea2012

    • Author(s)
      Mitsuko Takahashi, Katsumi Sakurai, Hisashi Hujii, and Koichi Saito
    • Journal Title

      Jpn. J. Food Chem. Safety

      Volume: 19 Pages: 149-154

    • NAID

      110009489102

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] センノシド標準溶液の安定性の検討及び分解物の解析2012

    • Author(s)
      高橋美津子,桜井克巳,斉藤貢一
    • Journal Title

      分析化学

      Volume: 61 Pages: 341-346

    • NAID

      10030135688

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Determination of exposure of dispensary drug preparers to cyclophosphamide by passive sampling and LC-MS/MS2012

    • Author(s)
      Nobuyuki Wakui, Tetuo Ookubo, Rie Ito, Yusuke Iwasaki1, Miyuki Mitui, Yuichi Yano, Koichi Saito, Hiroyuki Nakazawa
    • Journal Title

      Journal of Oncology Pharmacy Practice

      Volume: 未確定 Issue: 1 Pages: 31-37

    • DOI

      10.1177/1078155212451196

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 分子インプリンティングポリマーをクリーンアップに応用したハチミツ及びローヤルゼリー中クロラムフェニコールの分析2012

    • Author(s)
      斉藤貢一,波田梨公子,方波見志織,岩崎雄介,伊藤里恵,中澤裕之
    • Journal Title

      分析化学

      Volume: 61 Pages: 383-389

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 液体クロマトグラフィー/質量分析法による健康食品中のα-リポ酸の光学異性体分析2012

    • Author(s)
      小林由幸,斉藤貢一,岩崎雄介,伊藤里恵,中澤裕之
    • Journal Title

      分析化学

      Volume: 62 Pages: 109-114

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of drugs of abuse in biological specimens2011

    • Author(s)
      K. Saito、R. Saito、Y. Kikuchi、Y. Iwasaki、R. Ito
    • Journal Title

      J. Health Sci

      Volume: 57(6) Pages: 472-487

    • NAID

      130001869864

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Drugs of Abuse in Biological Specimens2011

    • Author(s)
      Koichi Saito, Rieko Saito, Yuu Kikuchi, Yusuke Iwasaki, Rie Ito, and Hiroyuki Nakazawa
    • Journal Title

      Journal of Health Science

      Volume: 57 Pages: 472-487

    • NAID

      130001869864

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improvement and validation the method using dispersive liquid-liquid microextraction with in situ derivatization followed by gas chromatography-mass spectrometry for determination of tricyclic antidepressants in human urine samples.2011

    • Author(s)
      Rie Ito, Masaru Ushiro, Yuki Takahashi, Koichi Saito, Tetsuo Ookubo, Yusuke Iwasaki, Hiroyuki Nakazawa
    • Journal Title

      J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.

      Volume: 879 Pages: 3714-3720

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 固相分散抽出―LC/TOF-MS法によるヒト血清中鎮痛薬・鎮痛補助薬(計30種)の一斉分析2013

    • Author(s)
      西山莉可、岩崎雄介、伊藤里恵、斉藤貢一
    • Organizer
      第57回日本薬学会関東支部大会
    • Place of Presentation
      東京都(帝京大学板橋キャンパス)
    • Year and Date
      2013-10-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 固相分散抽出-LC/MS法による血清中バンコマイシンの分析2012

    • Author(s)
      坂本泰洋、斉藤貢一、篠塚郁美、神野佑輝、岩崎雄介、伊藤里恵
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      東京都
    • Year and Date
      2012-10-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 健康食品中α-リポ酸の光学異性化の検討2012

    • Author(s)
      小林由幸、斉藤貢一、岩崎雄介、伊藤里恵
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道
    • Related Report
      2013 Final Research Report
  • [Presentation] 固相分散抽出-LC/TOF-MS法によるヒト血清および尿中バルビツール酸系薬物の分析2012

    • Author(s)
      小鍛治好恵、斉藤貢一、菊池優、岩崎雄介、伊藤里恵
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道
    • Related Report
      2013 Final Research Report
  • [Presentation] 健康食品中のα-リポ酸の光学異性化の検討2012

    • Author(s)
      小林由幸、斉藤貢一、岩崎雄介、伊藤里恵、中澤裕之
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道
    • Related Report
      2011 Research-status Report
  • [Presentation] 改良型固相分散抽出-LC/TOF-MS法による生体試料中のバルビツール酸系薬物の分析2011

    • Author(s)
      斉藤貢一、小鍛冶好恵、菊地優、小林由幸、岩崎雄介、伊藤里恵
    • Organizer
      日本法科学技術学会第17回学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2011-11-17
    • Related Report
      2013 Final Research Report
  • [Presentation] LC/MS/MSを用いた尿中α-リポ酸の光学異性体分析2011

    • Author(s)
      小林由幸、斉藤貢一、岩崎雄介、伊藤里恵
    • Organizer
      第55回日本薬学会関東支部大会
    • Place of Presentation
      千葉県
    • Year and Date
      2011-10-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 改良型固相分散抽出-LC/TOF-MS法による生体試料中のバルビツール酸系薬物の分析2011

    • Author(s)
      斉藤貢一、小鍛冶好恵、菊地優、小林由幸、岩崎雄介、伊藤里恵、中澤裕之
    • Organizer
      日本法科学技術学会 第17回学術集会
    • Place of Presentation
      東京都
    • Related Report
      2011 Research-status Report
  • [Presentation] LC/MS/MSを用いた尿中α-リポ酸の光学異性体分析2011

    • Author(s)
      小林由幸、斉藤貢一、岩崎雄介、伊藤里恵、中澤裕之
    • Organizer
      第55回 日本薬学会 関東支部大会
    • Place of Presentation
      千葉県
    • Related Report
      2011 Research-status Report
  • [Presentation] 液体クロマトグラフ/質量分析計(LC/MS)を用いた健康食品中のα-リポ酸の光学異性体分析2011

    • Author(s)
      小林由幸、斉藤貢一、白石龍太郎,信本早耶,岩崎雄介、伊藤里恵、中澤裕之
    • Organizer
      第101回日本食品衛生学会学術講演会
    • Place of Presentation
      東京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 固相分散抽出‐LC/TOF-MS法によるヒト血清中鎮痛薬・鎮痛補助薬(計30種)の一斉分析

    • Author(s)
      西山莉可,岩崎雄介,伊藤里恵,斉藤貢一
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      帝京大学薬学部
    • Related Report
      2013 Annual Research Report
  • [Presentation] 固相分散抽出-LC/MS 法による 血清中バンコマイシンの分析

    • Author(s)
      坂本泰洋,斉藤貢一,篠塚郁美,神野佑輝
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.hoshi.ac.jp/home/kyoiku/kyoushitsuhgaid/2kyoushitsu.bunseki.html

    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 遠心分離用チューブ2011

    • Inventor(s)
      斉藤貢一
    • Industrial Property Rights Holder
      星薬科大学
    • Industrial Property Rights Type
      実用新案
    • Filing Date
      2011-09-27
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 遠心分離用チューブ2011

    • Inventor(s)
      斉藤貢一
    • Industrial Property Rights Holder
      星薬科大学
    • Industrial Property Rights Type
      実用新案
    • Acquisition Date
      2011-11-16
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 遠心分離用チューブ2011

    • Inventor(s)
      斉藤貢一
    • Industrial Property Rights Holder
      学校法人星薬科大学
    • Filing Date
      2011
    • Acquisition Date
      2011
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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