| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
For the purpose of elucidate the pathogenesis of "chemical sensitivity", we have examined it by the relationship to the respiratory secretions that is innate biological defense reaction of the respiratory tract. We have focused on respiratory secretions through the noxious stimuli-sensitive receptor TRPV-1(transient receptor potential, vanilloid subfamily member 1), which is estimated to be exposed-stimulation sensitive site in the respiratory tract and used optical methods to measure the airway secretion for investigating the defense mechanism of MCS patients.Our consequence would be explained that the addition of capsaicin (10uM), which is the agonist of TRPV1, to the mucosal side mild increased airway secretion and it is elevated temporarily in the airway mucosa that is exposed formalin (20ppm) for 30-60min.
These data suggest the possibility of airway secretion is elevated temporarily in MCS patients.
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