Pathogenesis of hematological malignancies caused by viral infection
| Project/Area Number |
23591391
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 造血器腫瘍 / ウイルス / 癌 / 感染症 |
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| Research Abstract |
Some virus infections are closely associated with oncogenesis. In 2008, Merkel cell polyomavirus (MCPyV) was reported as the first tumor polyomavirus. The association of MCPyV with chronic lymphocytic leukemia (CLL) has been discussed in the Western world, whereas the prevalence of the virus in CLL cases in Eastern countries has not been investigated. In this study, we determined the prevalence and DNA loads of MCPyV in Japanese CLL cases. We found that MCPyV is present in a subset of Japanese CLL cases, but it is unclear that MCPyV have a direct causal role in Japanese CLL.
Since MCPyV can also infect monocytic cells, we investigated the prevalence of MCPyV in disorders of monocytic lineage. MCPyV DNA was not detected in any of our leukemia samples with the monocytic lineage, suggesting that MCPyV is unlikely to have played a pathogenetic role in the monocytic leukemias of these patients.
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] Inv olvement of KRAS G12A mutation in t he IL-2-independent growth of a hum an T-LGL leukemia cell line, PLT-22012
Author(s)
Mizutani N, Ito H, Hagiwara K, Koba yashi M, Hoshikawa A, Nishida Y, Ta kagi A, Kojima T, Suzuki M, Osawa Y, Ohishi K, Daibata M, Murate T
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Journal Title
Nagoya Journal of Medical Science
Volume: 74, (PMID : 2 3092099)
Pages: 261-271
Related Report
Peer Reviewed
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[Journal Article] Presence of Merkel cell polyomavirus in Japanese cutaneous squamous cell carcinoma.2011
Author(s)
Murakami M, Imajoh M, Ikawa T, Nakajima N, Kamioka M, Nemoto Y, Ujihara T, Uchiyama J, Matsuzaki S, Sano S, Daibata M.
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Journal Title
J Clin Virol.
Volume: 50
Issue: 1
Pages: 37-41
DOI
Related Report
Peer Reviewed
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[Presentation] KrasG12A mutation is responsible for thecytokine independent growth of a human LGL leukemia cell line, PLT2.2011
Author(s)
Mizutani N, Ito H, Hagiwara K, Murakami M, Kobayashi M, Hoshikawa A, Sobue S, Takagi A, Kojima T, Suzuki M, Ohnishi K, Naoe T, Daibata M, Murate T.
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋国際会議場（名古屋市）
Related Report
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[Presentation] Improved adsorption of Enterococcus faecalis bacteriophage φEF24C caused by a point mutation in a tail fiber gene.2011
Author(s)
Uchiyama J, Takemura I, Satoh M, Kato S, Ujihara T, Akechi K, Matsuzaki, S, Daibata M.
Organizer
International Union of Microbiological Societies (IUMS), XV International Congress of Virology
Place of Presentation
Sapporo Convention Center, Sapporo, Japan
Related Report
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[Presentation] Various sites of highly amplified DNA sequences in a pleomorphic type of a new rhambdomyosarcoma cell line, HS-RMS-2, detected by comparative genomic hybridization, chromosome microdissection and PCR analysis.2011
Author(s)
Taguchi T, Takaoka E, Sonobe H, Akimaru K, Sakamoto S, Shuin T, Daibata M, Tominaga A.
Organizer
The 102nd American Association for Cancer Research Annual Meeting.
Place of Presentation
Orange County Convention Center, Orland, Florida, USA
Related Report
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