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Involvement of Epithelial and endothelial to mesenchymal transition in tissue remolding of rheumatic diseases

Research Project

Project/Area Number 23591451
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

SAITO Kazuyoshi  産業医科大学, 医学部, 准教授 (30279327)

Co-Investigator(Kenkyū-buntansha) KOHNO Kimitoshi  産業医科大学, 医学部, 名誉教授 (00153479)
Co-Investigator(Renkei-kenkyūsha) TANAKA Yoshiya  産業医科大学, 医学部, 教授 (30248562)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsリモデリング抑制 / Wnt10 / 膠原病
Research Abstract

The aim of this study is to elucidate the mechanism of EMT and EndoMT in tissue remolding and fibrosis of rheumatic diseases and to develop a new treatment strategy for rheumatic diseases. We conducted immune-staining of skin,lung and kidney tissue from rheumatic disease including rheumatoid arthritis, systemic sclerosis and vasculitis. As a result, a hyperplasia of myofibroblast was observed at the site of prominent progression of tissue fibrosis and vascular remodeling due to endothelial dell proliferation. Immuno-staining revealed both the myoblast and endothelial cells express Wnt10a, suggesting signaling through Wnt10 might involvement in irreversible remodeling in rheumatic diseases. These provocative findings suggest that the inhibition of EndMT/EMT may be a promising target for clinical therapeutic translation in settings such as tissue remodeling which cause of irreversible organ damage in rheumatic deseases.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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