Pharmacological treatment for chronic spinal cord damage with special reference to blood-spinal barrier

• Project/Area Number: 23592166
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokushima
• Principal Investigator: KATOH Shinsuke 徳島大学, 大学病院, 教授 (30243687)
• Co-Investigator(Kenkyū-buntansha): HIGASHINO Kosaku 徳島大学, ヘルスバイオサイエンス研究部, 助教 (80380129) ; ENISHI Tetsuya 徳島大学, 大学病院, 特任助教 (20467806) ; 小坂 浩史 徳島大学, 大学病院, 助教 (00420547)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 脊髄障害 / 薬物療法 / 国際情報交換 / 脊髄 / 慢性障害 / 薬物 / アポトーシス

Research Abstract

Compression myelopathy is increasing as the aging of society increases. Complications sometimes make the aged patients unable to undertake decompression surgery. Therefore, development of novel pharmacological strategy for chronic spinal cord damage is needed. We planned to develop new chronically spinal cord compression animals which show stable neurological deficits. We showed apoptosis in the neuron and glial cells in chronically compressed spinal cord. Blood-spinal cord barrier was disrupted using horse raddish peroxidase injection study. However, we failed to develop the animals with stable neurological deficit animals. We failed to demonstrate the effect of drugs on neurological function.

Research Products

• [Journal Article] High incidence of acute traumatic spinal cord injury in a rural population in Japan in 2011 and 2012: An epidemiological study (2014)
  • Author(s): Katoh S, Enishi T, Sato N, Sairyo K
  • Journal Title: Spinal Cord Volume: 52 Pages: 264-7
• [Journal Article] Lanig I. www.elearnSCI.org - a global educational initiative of ISCoS (2013)
  • Author(s): Chhabra H S, Harvey L A, Muldoon S, Chaudhary S, Arora M, Brown D, Biering-Sorensen F, Wyndaele JJ, Charlifue S, Horsewell J, Ducharme S, Green D, Simpson D, Glinsky J, Weerts E, Upadhyay N, Aito S, Wing P, Katoh S, Kovindha A, Krassioukov A, Weeks C, Srikumar V, Reeves R, Siriwardane C, Hasnan N, Kalke YB
  • Journal Title: Spinal Cord Volume: 51(3) Pages: 176-182
• [Journal Article] www.elearnSCI.org - a global educational initiative of ISCoS (2013)
  • Author(s): Chhabra H S, Harvey L A, Muldoon S, Chaudhary S, Arora M, Brown D, Biering-Sorensen F, Wyndaele JJ, Charlifue S, Horsewell J, Ducharme S, Green D, Simpson D, Glinsky J, Weerts E, Upadhyay N, Aito S, Wing P, Katoh S, Kovindha A, Krassioukov A, Weeks C, Srikumar V, Reeves R, Siriwardane C, Hasnan N, Kalke YB, Lanig I
  • Journal Title: Spinal Cord Volume: 51 Issue: 3 Pages: 176-182
  • DOI: 10.1038/sc.2012.177
  • Peer Reviewed
• [Presentation] High incidence of cervical spinal cord injury in a rural area in Japanin2011: An epidemiological study (2013)
  • Author(s): Katoh, S, Enishi T, Sato N
  • Organizer: 52^<nd> Annual Meeting, International Spinal Cord Society
  • Place of Presentation: Haliq Congress Center, Istanbul, Turkey
• [Presentation] High incidence of cervical spinal cord injury in a rural area in Japan in 2011. An epidemiological study (2013)
  • Author(s): S. Katoh, K. Higashino, M. Takahashi, T. Enishi, N. Sato
  • Organizer: 52nd Annual scientific meeting of the International Spinal Cord Society
  • Place of Presentation: Halic Congress Center、イスタンブール、トルコ
• [Book] Oxidative stress as secondary injury mechanism. In : Neuroprotection and regeneration of the spinal cord . Uchida K, Nakamura M, Ozawa H, Katoh S, Toyama Y(Eds) (2014)
  • Author(s): Katoh S, Hamada Y, Chikawa T
  • Total Pages: 419
  • Publisher: Springer Japan
• [Book] Neuroprotection and regeneration of the spinal cord (2014)
  • Author(s): Katoh S, Hamada Y, Chikawa T
  • Total Pages: 409
  • Publisher: Springer Japan
• [Book] Neuroprotection and Regeneration of the Spinal Cord (2013)
  • Author(s): S. Katoh
  • Total Pages: 250
  • Publisher: Preventive effects of lecithinized superoxide dismutase and methylprednisolone on spinal cord injury in rats: transcriptional regulation of inflammatory and neurotrophic genes