| Project/Area Number |
23659730
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Heian Jogakuin(St.Agnes')University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ASHIHARA Eishi 京都府立医科大学, 医学(系)研究科, 講師 (70275197)
HOSOGI Shigekuni 京都府立医科大学, 医学(系)研究科, 講師 (30433254)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 骨肉腫 / アクリジンオレンジ / 光線力学的治療法 / 微粒子 / エキソゾーム / 免疫療法 / マクロファージ / 骨肉種 / 細胞内小器官 / がん免疫 / エクソゾーム |
|---|
| Research Abstract |
In this study, we undertook to investigate inhibition effect oftumor growth and pulmonary metastasis on mouse osteosarcoma by immurlotherapy withmicroparticles induced by photodynamic therapy with acridine orange. Results showed thatthese microparticles including exQsomes did rlot inhibit tumor growth and pulmonarymetastasis, because they did not activate immunoactivity via macrophages
|
