• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishment of a novel immunoregulatory system by enrichment of tolerogenic DCs in donor cornea

Research Project

Project/Area Number 23659821
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionTokyo Medical University

Principal Investigator

KUMAKURA Shigeto  東京医科大学, 医学部, 講師 (90271296)

Co-Investigator(Renkei-kenkyūsha) HATTORI Takaaki  東京医科大学, 医学部, 講師 (20408173)
USUI Yoshihiko  東京医科大学, 医学部, 講師 (50408142)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords角膜移植 / 制御性樹状細胞 / 拒絶反応 / 移植免疫
Research Abstract

Significant interest has been focused on the use of ex vivo manipulated dendritic cells (DCs) to optimally induce transplant tolerance and promote allograft survival. Though it is understood that donor-derived tolerogenic DCs suppress the direct pathway of allosensitization, whether such DCs can similarly suppress the indirect pathway remains unclear. We therefore utilized the murine model of corneal transplantation to address this, as these allografts are rejected in an indirect pathway dominant fashion. Interestingly, recipients administered with donor bone marrow derived regulatory DCs (DCregs) generated via culturing with GMCSF, IL-10 and TGF-b1, significantly prolonged survival of corneal allografts. We conclude that donor derived tolerogenic DCs significantly suppress the indirect pathway, thereby identifying a novel regulatory mechanism for these cells in transplantation.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Depiction of cavity formation in terrien marginal degeneration by anterior segment optical coherence tomography2013

    • Author(s)
      Takaaki Hattori
    • Journal Title

      Cornea

      Volume: 32 Issue: 5 Pages: 615-618

    • DOI

      10.1097/ico.0b013e318259c970

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Non-Descemet's stripping automated endothelial keratoplasty for bullous keratopathy secondary to iridoschisis

    • Author(s)
      Terumi Minezaki, Takaaki Hattori, Hayate Nakagawa, Shigeto Kumakura, Hiroshi Goto
    • Journal Title

      Clinical Ophthalmology

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 全層角膜移植後のサイトメガロウイルス角膜内皮炎症例に対するウイルス感染細胞の検索2013

    • Author(s)
      熊倉重人
    • Organizer
      角膜カンファランス
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 制御性樹状細胞による角膜移植拒絶反応の抑制2012

    • Author(s)
      服部貴明
    • Organizer
      Ocular immunology meeting
    • Place of Presentation
      和歌山
    • Related Report
      2012 Annual Research Report
  • [Presentation] 制御性樹状細胞による角膜移植拒絶反応の抑制2011

    • Author(s)
      服部貴明
    • Organizer
      東京医大医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 制御性樹状細胞による角膜移植拒絶反応の抑制2011

    • Author(s)
      服部貴明 熊倉重人 後藤 浩
    • Organizer
      角膜カンファラン 2011
    • Place of Presentation
      東京
    • Year and Date
      2011-02-18
    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi