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Development of fluorescence-guided HPB surgery and application of indocyanine green-fluorescence imaging to photodynamic therapy for liver cancer

Research Project

Project/Area Number 23689060
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionThe University of Tokyo

Principal Investigator

ISHIZAWA Takeaki  東京大学, 医学部附属病院, 助教 (10422312)

Research Collaborator KOKUDO Norihiro  東京大学医学部附属病院, 肝胆膵・人工臓器移植外科, 教授 (00205361)
KAMIYA Mako  東京大学, 大学院医学系研究科 生体情報学, 助教 (90596462)
URANO Yasuteru  東京大学, 大学院医学系研究科 生体情報学, 教授 (20292956)
SHIBAHARA Junji  東京大学, 大学院医学系研究科 人体病理学・病理診断学, 准教授 (60334380)
FUKAYAMA Masashi  東京大学, 大学院医学系研究科 靭帯病理学・病理診断学, 准教授 (70281293)
MIDORIKAWA Yutaka  日本大学医学部附属板橋病院, 消化器外科, 助教 (10292905)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Keywords蛍光イメージング / インドシアニングリーン / 肝細胞癌 / 転移性肝癌 / 膵液漏 / 光線力学的治療 / 手術ナビゲーション / 胆道造影 / Indocyanine green / 肝切除 / 膵切除 / 胆嚢摘出術 / 腹腔鏡手術 / 癌イメージング / 蛍光ナビゲーション / 肝癌 / 膵癌
Research Abstract

This study revealed mechanistic background of fluorescence imaging of primary and secondary liver cancers using preoperatively-administered indocyanine green (ICG), which may lead to development of photodynamic therapy for hepatic malignancies. In the present study, novel near-infrared laparoscopic imaging systems with improved color/fluorescence-image quality was actively used for evaluation of its efficacy in delineating bile ducts, portal/arterial systems, and cancerous tissues using ICG-fluorescence imaging techniques during laparoscopic hepato-biliary-pancreatic surgery. Novel fluorescence probes, which can emit fluorescence signals immediately after enzymatic reactions with cancer-specific membrane enzymes or pancreatic enzymes, were also developed and applied to identify biliary and pancreatic adenocarcinoma tissues and to enable real-time visualization of pancreatic juice leaking from pancreatic stump during surgery.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (114 results)

All 2014 2013 2012 2011 Other

All Journal Article (54 results) (of which Peer Reviewed: 25 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (52 results) (of which Invited: 9 results) Book (4 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 3 results)

  • [Journal Article] Laparoscopic hepatectomy under epidural anesthesia2014

    • Author(s)
      Yamamoto K, Ishizawa T, Kokudo N, et al
    • Journal Title

      Annals of Surgery

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Visualization of subcapsular hepatic malignancy by indocyanine-green fluorescence imaging during laparoscopic hepatectomy2014

    • Author(s)
      Kudo H, Ishizawa T, Kaneko J, Kokudo N
    • Journal Title

      Surgical Endoscopy

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] The beginning of a new era of digestive surgery guided by fluorescence imaging2014

    • Author(s)
      Ishizawa T, Kokudo N
    • Journal Title

      Liver Cancer

      Volume: 3 Pages: 6-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Application of indocyanine green-fluorescence imaging to full-thickness cholecystectomy2014

    • Author(s)
      Morita K, Ishizawa T, Kaneko J, Kokudo N, et al
    • Journal Title

      Asian Journal of Endoscopic Surgery

      Volume: 7 Pages: 193-5

    • Related Report
      2013 Final Research Report
  • [Journal Article] Indocyanine green fluorescence imaging in the surgical management of liver cancers : Current facts and future implications2014

    • Author(s)
      Lim C, Ishizawa T, Kokudo N, et al
    • Journal Title

      Journal of Visceral Surgery

      Volume: 151 Pages: 117-24

    • Related Report
      2013 Final Research Report
  • [Journal Article] Estimation of portal uptake function in the venous congestive area after hemi-hepatectomy : postoperative contrast-enhanced magnetic resonance imaging and intraoperative indocyanine green-fluorescence imaging2014

    • Author(s)
      Kawaguchi Y, Ishizawa T, Kokudo N
    • Journal Title

      Journal of Hepato-biliary-pancreatic Sciences

      Volume: 21

    • Related Report
      2013 Final Research Report
  • [Journal Article] Impact of surgery on quality of life in patients with hepatocellular carcinoma2014

    • Author(s)
      Mise Y, Satou S, Ishizawa T, Kokudo N, et al
    • Journal Title

      World Journal of Surgery

      Volume: 38 Pages: 958-67

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mechanistic background and clinical applications of indocyanine green fluorescence imaging of hepatocellular carcinoma2014

    • Author(s)
      Ishizawa T, Masuda K, Urano Y, Kawaguchi Y, Kaneko J, Shibahara J, Fukayama M, Midorikawa Y, Kokudo N, et al
    • Journal Title

      Annals of Surgical Oncology

      Volume: 21 Pages: 440-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Laparoscopy-assisted hybrid left-side donor hepatectomy : is it truly less invasive for living donors?2014

    • Author(s)
      Ishizawa T, Hasegawa K, Kokudo N
    • Journal Title

      World Journal of Surgery

      Volume: 38 Pages: 1560-1

    • Related Report
      2013 Final Research Report
  • [Journal Article] Using a 'no drain' policy in 342 laparoscopic hepatectomies : which factors predict failure?2014

    • Author(s)
      Ishizawa T, Zuker NB, Kokudo N, et al
    • Journal Title

      HPB (Oxford)

      Volume: 16 Pages: 494-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] Photodynamic therapy for human hepatoma-cell-line tumors utilizing biliary excretion properties of indocyanine green2014

    • Author(s)
      Kaneko J, Inagaki Y, Ishizawa T, Kokudo N, et al
    • Journal Title

      Journal of Gastroenterology

      Volume: 49 Pages: 110-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] Photodynamic therapy for human hepatoma-cell-line tumors utilizing biliary excretion properties of indocyanine green2014

    • Author(s)
      Kaneko J, Inagaki Y, Ishizawa T, Gao J, Tang W, Aoki T, Sakamoto Y, Hasegawa K, Sugawara Y, Kokudo N
    • Journal Title

      Journal of Gastroenterology

      Volume: 49 Pages: 110-116

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Using a 'no drain' policy in 342 laparoscopic hepatectomies: which factors predict failure?2014

    • Author(s)
      Ishizawa T, Zuker NB, Conrad C, Lei HJ, Ciacio O, Kokudo N, Gayet B
    • Journal Title

      HPB

      Volume: 未定 Issue: 5 Pages: 494-499

    • DOI

      10.1111/hpb.12165

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laparoscopy-Assisted Hybrid Left-side Donor Hepatectomy: Is it Truly Less Invasive for Living Donors?2014

    • Author(s)
      Ishizawa T, Hasegawa K, Kokudo N
    • Journal Title

      World Journal of Surgery

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanistic background and clinical applications of indocyanine green fluorescence imaging of hepatocellular carcinoma.2014

    • Author(s)
      Ishizawa T, Masuda K, Urano Y, Kawaguchi Y, Satou S, Kaneko J, Hasegawa K, Shibahara J, Fukayama M, Tsuji S, Midorikawa Y, Aburatani H, Kokudo N.
    • Journal Title

      Ann Surg Oncol.

      Volume: 21 Issue: 2 Pages: 440-8

    • DOI

      10.1245/s10434-013-3360-4

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Impact of surgery on quality of life in patients with hepatocellular carcinoma2014

    • Author(s)
      Mise Y, Satou S, Ishizawa T, Kaneko J, Aoki T, Hasegawa K, Sugawara Y, Makuuchi M, Kokudo N
    • Journal Title

      World Journal of Surgery

      Volume: 38 Issue: 4 Pages: 958-967

    • DOI

      10.1007/s00268-013-2342-9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of portal uptake function in the venous congestive area after hemi-hepatectomy: postoperative contrast-enhanced magnetic resonance imaging and intraoperative indocyanine green-fluorescence imaging2014

    • Author(s)
      Kawaguchi Y, Ishizawa T, Kokudo N
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 21 Issue: 1

    • DOI

      10.1002/jhbp.55

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraoperative Identification of Bile Duct Perforation Following ERCP Using Indocyanine Green-Fluorescence Imaging2014

    • Author(s)
      Kawaguchi Y, Ishizawa T, Harada Y, Nagai M, Nomura Y, Hata S, Shimura K, Kokudo N, Tanaka N
    • Journal Title

      Dig Dis Sci

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indocyanine green fluorescence imaging in the surgical management of liver cancers: Current facts and future implications2014

    • Author(s)
      Lim C, Vibert E, Azoulay D, Salloum C, Ishizawa T, Yoshioka R, Mise Y, Sakamoto Y, Aoki T, Sugawara Y, Hasegawa K, Kokudo N
    • Journal Title

      J Visc Surg

      Volume: 未定 Issue: 2 Pages: 117-124

    • DOI

      10.1016/j.jviscsurg.2013.11.003

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of subcapsular hepatic malignancy by indocyanine-green fluorescence imaging during laparoscopic hepatectomy2014

    • Author(s)
      Kudo H, Ishizawa T, Tani K, Harada N, Ichida A, Shimizu A, Kaneko J, Aoki T, Sakamoto Y, Sugawara Y, Hasegawa K, Kokudo N
    • Journal Title

      Surgical Endoscopy

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the Therapeutic Outcomes Between Surgical Resection and Percutaneous Ablation for Small Hepatocellular Carcinoma2014

    • Author(s)
      Hasegawa K, Aoki T, Ishizawa T, Kaneko J, Sakamoto Y, Sugawara Y, Kokudo N
    • Journal Title

      Annals of Surgical Oncology

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of Donor and Recipient Single Nucleotide Polymorphisms of IL28B rs8099917 in Living Donor Liver Transplantation for Hepatitis C2014

    • Author(s)
      Harada N, Tamura S, Sugawara Y, Togashi J, Ishizawa T, Kaneko J, Aoki T, Sakamoto Y, Hasegawa K, Tanaka T, Yamashiki N, Kokudo N
    • Journal Title

      PLoS One

      Volume: 9 Issue: 3 Pages: e90462-e90462

    • DOI

      10.1371/journal.pone.0090462

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma2014

    • Author(s)
      Kondo M, Ishizawa T, Enooku K, Tokuhara Y, Ohkawa R, Uranbileg B, Nakagawa H, Tateishi R, Yoshida H, Kokudo N, Koike K, Yatomi Y, Ikeda H
    • Journal Title

      Clin Chim Acta

      Volume: 433C Pages: 128-134

    • DOI

      10.1016/j.cca.2014.03.006

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laparoscopic hepatectomy under epidural anesthesia2014

    • Author(s)
      Yamamoto K, Ishizawa T, Kokudo N
    • Journal Title

      Annals of Surgery

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraoperative identification of bile duct perforation following ERCP using indocyanine green-fluorescence imaging2013

    • Author(s)
      Kawaguchi Y, Ishizawa T, Kokudo N, et al
    • Journal Title

      Digestive Diseases and Sciences

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Risk factors of post-operative recurrence and adequate surgical approach to improve long-term outcomes of hepatocellular carcinoma2013

    • Author(s)
      Shindoh J, Ishizawa T, Kokudo N, et al
    • Journal Title

      HPB (Oxford)

      Volume: 15 Pages: 31-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] Low hepatitis C viral load predicts better long-term outcomes in patients undergoing resection of hepatocellular carcinoma irrespective of serologic eradication of hepatitis C virus2013

    • Author(s)
      Shindoh J, Hasegawa K, Ishizawa T, Kokudo N, et al
    • Journal Title

      Journal of Clinical Oncology

      Volume: 31 Pages: 766-73

    • Related Report
      2013 Final Research Report
  • [Journal Article] A worldwide survey of the current daaily practice in liver surgery2013

    • Author(s)
      Mise Y, Sakamoto Y, Ishizawa T, Kokudo N, et al
    • Journal Title

      Liver Cancer

      Volume: 2 Pages: 55-66

    • Related Report
      2013 Final Research Report
  • [Journal Article] Reply to : "portal uptake function in veno-occlusive regions evaluated by real-time fluorescent imaging using indocyanine green"2013

    • Author(s)
      Kawaguchi Y, Ishizawa T, Kokudo N
    • Journal Title

      Jounal of Hepatology

      Volume: 59 Pages: 632-3

    • Related Report
      2013 Final Research Report
  • [Journal Article] Indocyanine green fluorescent imaging for detecting extrahepatic metastasis of hepatocellular carcinoma2013

    • Author(s)
      Satou S, Ishizawa T, Kokudo N, et al
    • Journal Title

      Journal of Gastroenterology

      Volume: 48 Pages: 1136-43

    • Related Report
      2013 Final Research Report
  • [Journal Article] Visualization of the leakage of pancreatic juice using a chymotrypsin-activated fluorescent probe2013

    • Author(s)
      Yamashita S, Sakabe M (double first author), Ishizawa T, Kokudo N, et al
    • Journal Title

      British Journal of Surgery

      Volume: 100 Pages: 1220-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Identification of veno-occlusive regions in a right liver graft after reconstruction of vein segments 5 and 8: Application of indocyanine green fluorescence imaging2013

    • Author(s)
      Kawaguchi Y, Sugawara Y, Ishizawa T, et al
    • Journal Title

      Liver Transplantation

      Volume: 19 Pages: 778-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] Portal uptake function in veno-occlusive regions evaluated by real-time fluorescent imaging using indocyanine green2013

    • Author(s)
      Kawaguchi Y, Ishizawa T, Miyata Y, Kokudo N, et al
    • Journal Title

      Journal of Hepatology

      Volume: 58 Pages: 247-53

    • Related Report
      2013 Final Research Report
  • [Journal Article] Indocyanine green fluorescent imaging for detecting extrahepatic metastasis of hepatocellular carcinoma.2013

    • Author(s)
      Satou S, Ishizawa T, Masuda K, Kaneko J, Aoki T, Sakamoto Y, Hasegawa K, Sugawara Y, Kokudo N
    • Journal Title

      Journal of Gastroenterology

      Volume: 48 Issue: 10 Pages: 1136-1143

    • DOI

      10.1007/s00535-012-0709-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Education and imaging: Hepatobiliary and pancreatic: Identification of recurrent hepatocellular carcinoma by intraoperative fluorescent imaging2013

    • Author(s)
      Kawaguchi Y, Aoki T, Ishizawa T, Arita J, Satou S, Kaneko J, Sakamoto Y, Sugawara Y, Hasegawa K, Kokudo N
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 28 Pages: 587-587

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reply to: "portal uptake function in veno-occlusive regions evaluated by real-time fluorescent imaging using indocyanine green"2013

    • Author(s)
      Kawaguchi Y, Ishizawa T, Kokudo N
    • Journal Title

      Journal of Hepatology

      Volume: 59 Pages: 632-633

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Identification of veno-occlusive regions in a right liver graft after reconstruction of vein segments 5 and 8: application of indocyanine green fluorescence imaging2013

    • Author(s)
      Kawaguchi Y, Sugawara Y, Ishizawa T, Satou S, Kaneko J, Tamura S, Aoki T, Sakamoto Y, Hasegawa K, Kokudo N
    • Journal Title

      Liver Transplantation

      Volume: 19 Issue: 7 Pages: 778-779

    • DOI

      10.1002/lt.23657

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of the leakage of pancreatic juice using a chymotrypsin-activated fluorescent probe2013

    • Author(s)
      Yamashita S, Sakabe M, Ishizawa T, Hasegawa K, Urano Y, Kokudo N
    • Journal Title

      British Journal of Hepatology

      Volume: 100 Pages: 1220-1228

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Worldwide Survey of the Current Daily Practice in Liver Surgery2013

    • Author(s)
      Mise Y, Sakamoto Y, Ishizawa T, Kaneko J, Aoki T, Hasegawa K, Sugawara Y, Kokudo N
    • Journal Title

      Liver Cancer

      Volume: 2 Pages: 55-66

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Indocyanine green fluorescent imaging for detecting extrahepatic metastasis of hepatocellular carcinoma.2013

    • Author(s)
      Satou S
    • Journal Title

      Journal of Gastroenterology

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Portal uptake function in veno-occlusive regions evaluated by real-time fluorescent imaging using indocyanine green.2013

    • Author(s)
      Kawaguchi Y
    • Journal Title

      Journal of Hepatology

      Volume: 58 Issue: 2 Pages: 247-253

    • DOI

      10.1016/j.jhep.2012.09.028

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical application of fluorescence imaging of liver cancer using indocyanine green2012

    • Author(s)
      Kokudo N, Ishizawa T
    • Journal Title

      Liver Cancer

      Volume: 1 Pages: 15-21

    • Related Report
      2013 Final Research Report
  • [Journal Article] Laparoscopic Segmentectomy of the Liver : From Segment I to VIII2012

    • Author(s)
      Ishizawa T, Gumbs AA, Kokudo N, Gayet B
    • Journal Title

      Annals of Surgery

      Volume: 256 Pages: 959-64

    • Related Report
      2013 Final Research Report
  • [Journal Article] Indocyanine green reinjection technique for use in fluorescent angiography concomitant with cholangiography during laparoscopic cholecystectomy2012

    • Author(s)
      Kaneko J, Ishizawa T, Kokudo N, et al
    • Journal Title

      Surgical Laparoscopy, Endoscopy & Percutaneous Techniques

      Volume: 22 Pages: 341-4

    • Related Report
      2013 Final Research Report
  • [Journal Article] Hepatocellular carcinoma : Western and Eastern surgeons' points of view2012

    • Author(s)
      Vibert E, Ishizawa T
    • Journal Title

      Journal of Visceral Surgery

      Volume: 149

    • Related Report
      2013 Final Research Report
  • [Journal Article] Positive and negative staining of hepatic segments by use of fluorescent imaging techniques during laparoscopic hepatectomy2012

    • Author(s)
      Ishizawa T, Zuker NB, Kokudo N, Gayet B
    • Journal Title

      Archives of Surgery

      Volume: 147 Pages: 393-4

    • Related Report
      2013 Final Research Report
  • [Journal Article] Laparoscopic segmentectomy of the liver: from segment I to VIII2012

    • Author(s)
      Ishizawa T
    • Journal Title

      Annals of Surgery

      Volume: 256 Issue: 6 Pages: 959-964

    • DOI

      10.1097/sla.0b013e31825ffed3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indocyanine green reinjection technique for use in fluorescent angiography concomitant with cholangiography during laparoscopic cholecystectomy2012

    • Author(s)
      Kaneko J
    • Journal Title

      Surgical Laparoscopy, Endoscopy & Percutaneous Techniques

      Volume: 22 Issue: 4 Pages: 341-344

    • DOI

      10.1097/sle.0b013e3182570240

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocellular carcinoma: Western and Eastern surgeons' points of view2012

    • Author(s)
      Vibert E
    • Journal Title

      Journal of Visceral Surgery

      Volume: 149 Issue: 5 Pages: e302-e306

    • DOI

      10.1016/j.jviscsurg.2012.05.001

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Positive and negative staining of hepatic segment by fluorescent imaging technique during laparoscopic hepatectomy2012

    • Author(s)
      Ishizawa T, et al.
    • Journal Title

      Archives of Surgery

      Volume: 147 Issue: 4 Pages: 393-394

    • DOI

      10.1001/archsurg.2012.59

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ICG蛍光法を用いた術中胆道造影:現況と将来展望2012

    • Author(s)
      石沢武彰, 河口義邦, 國土典宏
    • Journal Title

      胆道

      Volume: 26 Pages: 34-100

    • NAID

      130004838852

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ICGを活用した肝癌蛍光イメージングの臨床応用2012

    • Author(s)
      石沢武彰、宮田陽一、國土典宏
    • Journal Title

      実験医学

      Volume: 30(印刷中)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Hepatobiliary surgery guided by a novel fluorescent imaging technique for visualizing hepatic arteries, bile ducts, and liver cancers on color images2011

    • Author(s)
      Kawaguchi Y, Ishizawa T, Kokudo N, et al
    • Journal Title

      Journal of the American College of Surgeons

      Volume: 212

    • Related Report
      2013 Final Research Report
  • [Journal Article] Laparoscopic segmentectomy of the liver : from segment I to VIII

    • Author(s)
      Ishizawa T
    • Journal Title

      Annals of Surgery

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Real-time visualization of pancreatic leak using a chymotrypsin-activated fluorescent probe during pancreatic surgery2014

    • Organizer
      SPIE BiOS
    • Place of Presentation
      San Francisco, California, US
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] New Approaches to Visualizing Pancreatic Leak and Regional Portal Uptake During HPB Surgery2014

    • Organizer
      The 13th Annual Surgery of the Foregut Symposium
    • Place of Presentation
      Miami, Florida, US
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Rapid and Sensitive Imaging of Cancer Cells in Resected Human Live Tissues by Novel Fluorescence Probes forγ-glutamyltranspeptidase2014

    • Organizer
      The 13th Annual Surgery of the Foregut Symposium
    • Place of Presentation
      Miami, Florida, US
    • Related Report
      2013 Final Research Report
  • [Presentation] Surgical technique and clinical significance of anatomic segmentectomy in the treatment of hepatic malignancy2014

    • Organizer
      The 13th Annual Surgery of the Foregut Symposium
    • Place of Presentation
      Miami, Florida, US
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Rapid and Sensitive Imaging of Cancer Cells in Resected Human Live Tissues by Novel Fluorescence Probes for γ-glutamyltranspeptidase2014

    • Author(s)
      Ishizawa T, Kamiya M, Urano Y, Kokudo N
    • Organizer
      The 13th Annual Surgery of the Foregut Symposium
    • Place of Presentation
      Miami, Florida, US
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Application of ICG fluorescence imaging to laparoscopic HPB surgery2014

    • Author(s)
      Ishizawa T, Kokudo N
    • Organizer
      The 34th Annual Meeting & 2014 International Symposium
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 小規模な鏡視下肝切除・膵切除を確実に行うための工夫2013

    • Organizer
      第26回小切開・鏡視外科学会
    • Place of Presentation
      東京
    • Year and Date
      2013-11-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝胆膵手術への応用を目指した癌蛍光イメージング法の開発2013

    • Organizer
      第1回がんと代謝研究会
    • Place of Presentation
      鶴岡
    • Year and Date
      2013-11-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 減黄過程中の血中δビリルビン分画と肝機能の推移2013

    • Organizer
      JDDW2013
    • Place of Presentation
      東京
    • Year and Date
      2013-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 病態解明のためのICG蛍光法:肝静脈閉塞領域の機能評価と肝癌手術診断法の基礎的検討2013

    • Organizer
      第19回肝血流動態イメージ研究会
    • Place of Presentation
      東京
    • Year and Date
      2013-01-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Translational research in fluorescent imaging of liver cancers : ICG and novel agents2013

    • Organizer
      The 8th International Meeting of Hepatocellular Carcinoma; Eastern and Western Experiences
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of ICG fluorescence imaging for HCC2013

    • Organizer
      The 3rd APASL HCC Conference
    • Place of Presentation
      Cebu, Philippines
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 肝S6/S7腫瘍の切除における腹腔鏡下手術の適応選択と手技の工夫2013

    • Author(s)
      石沢武彰、清水篤志、河野義春、西岡裕次郎、國土貴嗣、宮田明典、冲永裕子、市田晃彦、竹村信行、金子順一、青木琢、阪本良弘、菅原寧彦、長谷川潔、國土典宏
    • Organizer
      日本内視鏡外科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 上腹部手術の既往のある患者に腹腔鏡下肝切除を適用する際の工夫2013

    • Author(s)
      石沢武彰、長谷川潔、山本訓史、清水篤志、河野義春、西岡裕次郎、國土貴嗣、宮田明典、冲永裕子、市田晃彦、竹村信行、金子順一、青木琢、阪本良弘、菅原寧彦、國土典宏
    • Organizer
      肝臓内視鏡外科研究会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腹腔鏡下膵体尾部切除における細径bipolar鉗子の活用2013

    • Author(s)
      石沢武彰、清水篤志、宮田明典、市田晃彦、金子順一、青木琢、阪本良弘、菅原寧彦、長谷川潔、國土典宏
    • Organizer
      膵臓内視鏡外科研究会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小規模な鏡視下肝切除・膵切除を確実に行うための工夫2013

    • Author(s)
      石沢武彰1、長谷川潔、井上陽介、齋浦明夫、菅原寧彦、國土典宏
    • Organizer
      日本小切開鏡視外科学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 肝胆膵手術への応用を目指した癌蛍光イメージング法の開発2013

    • Author(s)
      石沢 武彰、神谷 真子、浦野 泰照、國土 典宏
    • Organizer
      がんと代謝研究会
    • Place of Presentation
      鶴岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 肝胆膵癌,肝区域,胆管,および膵液漏を描出するための術中蛍光イメージング技術の開発2012

    • Organizer
      第25回日本内視鏡外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-12-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸癌転移に対する腹腔鏡下肝切除:部分切除から拡大右葉切除まで2012

    • Organizer
      第12回平成外科研究会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Indocyanine green蛍光法による肝細胞癌診断の機序解明と光線力学的治療への応用2012

    • Organizer
      JDDW2012
    • Place of Presentation
      神戸
    • Year and Date
      2012-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] "No prophylactic drainage policy"に基づく腹腔鏡下肝切除342例(IMM, Paris)の手術成績の検討2012

    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山
    • Year and Date
      2012-07-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 蛍光観察が拓く腹腔鏡手術の新機軸-基本と新しいアイディア-2012

    • Organizer
      第67回日本消化器外科学会総会ランチョンセミナー
    • Place of Presentation
      富山
    • Year and Date
      2012-07-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 蛍光ナビゲーションを応用した鏡視下肝胆膵手術の開発2012

    • Organizer
      第24回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-05-31
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝胆道手術のための次世代蛍光ナビゲーションシステムの開発2012

    • Organizer
      第113回日本外科学会総会ランチョンセミナー
    • Place of Presentation
      千葉
    • Year and Date
      2012-04-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Gayet教授の肝胆膵腹腔鏡手術:革新か、異端か2012

    • Organizer
      第19回Research in Oncology Seminar
    • Place of Presentation
      盛岡
    • Year and Date
      2012-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Gayet教授(Paris)の肝胆膵腹腔鏡手術2012

    • Author(s)
      石沢武彰
    • Organizer
      第19回Research in Oncology Seminar
    • Place of Presentation
      盛岡(招待講演)
    • Year and Date
      2012-03-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 最先端の肝胆膵腹腔鏡手術2012

    • Organizer
      外科学Update Seminar
    • Place of Presentation
      東京
    • Year and Date
      2012-03-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Surgical techniques for completing anatomically accurate laparoscopic segmentectomy of the liver2012

    • Organizer
      The 10th world congress of International Hepato-pancreatic-biliary association
    • Place of Presentation
      Paris, France
    • Related Report
      2013 Final Research Report
  • [Presentation] Mechanistic background of indocyanine green-fluorescent imaging for intraoperative identification of hepatocellular carcinoma2012

    • Organizer
      World Molecular Imaging Congress
    • Place of Presentation
      Dublin, Ireland
    • Related Report
      2013 Final Research Report
  • [Presentation] Bile duct detectabilities of indocyanine green-fluorescent cholangiography during laparoscopic cholecystectomy2012

    • Organizer
      The Scientific Papers Sessions at the American College of Surgeons 98th Clinical Congress
    • Place of Presentation
      Chicago, US
    • Related Report
      2013 Final Research Report
  • [Presentation] Lateral approach using intercostal trocars and ICG-fluorescent imaging for accurate laparoscopic hepatectomy2012

    • Organizer
      The 6th International Congress of Society of Laparoscopic Surgeons of Bangladesh
    • Place of Presentation
      Dhaka, Bangladesh
    • Related Report
      2013 Final Research Report
  • [Presentation] 腹腔鏡下低位前方切除と膵頭十二指腸切除後の肝門部胆管癌に対する完全鏡視下拡大左肝切除2011

    • Author(s)
      石沢武彰
    • Organizer
      第24回日本内視鏡外科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2011-12-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] GAYET教授の腹腔鏡下肝切除:最先端の技術とその向こう側2011

    • Organizer
      第5回肝臓内視鏡外科研究会教育講演
    • Place of Presentation
      東京
    • Year and Date
      2011-11-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Gayet教授の腹腔鏡下肝切除2011

    • Author(s)
      石沢武彰
    • Organizer
      第5回肝臓内視鏡外科研究会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Clinical application of indocyanine green-fluorescent imaging for real-time identification of liver cancers2011

    • Author(s)
      Takeaki Ishizawa
    • Organizer
      21st World Congress of International Association of Surgeons, Gastroenterologists, and Oncologists
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Synchronous metastasis : Techniques and Strategies2011

    • Organizer
      The 19th international congress of the European Association for Endoscopic Surgery
    • Place of Presentation
      Torino, Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] Clinical application of indocyanine green-fluorescent imaging for the real-time identification of liver cancers2011

    • Organizer
      The 20th world congress of the IASGO
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Lateral approach using intercostal trocars and ICG-fluorescent imaging

    • Author(s)
      Takeaki Ishizawa
    • Organizer
      6th International Congress of Society of Laparoscopic Surgeons of Bangladesh
    • Place of Presentation
      Dhaka, Bangladesh
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Bile duct detectabilities of indocyanine green-fluorescent cholangiography during laparoscopic cholecystectomy

    • Author(s)
      Takeaki Ishizawa
    • Organizer
      The American College of Surgeons 98th Clinical Congress
    • Place of Presentation
      Chicago, US
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mechanistic background of indocyanine green-fluorescent imaging for intraoperative identification of hepatocellular carcinoma

    • Author(s)
      Takeaki Ishizawa
    • Organizer
      2012 World Molecular Imaging Congress
    • Place of Presentation
      Dublin, Ireland
    • Related Report
      2012 Annual Research Report
  • [Presentation] Surgical techniques for completing anatomically accurate laparoscopic segmentectomy of the liver

    • Author(s)
      Takeaki Ishizawa
    • Organizer
      The 10th world congress of International Hepato-pancreatic-biliary association
    • Place of Presentation
      Paris, France
    • Related Report
      2012 Annual Research Report
  • [Presentation] ICG-Fluorescent Imaging during Liver Surgery for Evaluation of Portal Uptake Function of Venous Congested Regions

    • Author(s)
      Yoshikuni Kawaguchi
    • Organizer
      The 10th world congress of International Hepato-pancreatic-biliary association
    • Place of Presentation
      Paris, France
    • Related Report
      2012 Annual Research Report
  • [Presentation] Novel fluorescent agents enabling real-time identification of pancreatic juice via visualization of activity of protease

    • Author(s)
      Suguru Yamashita
    • Organizer
      The 10th world congress of International Hepato-pancreatic-biliary association
    • Place of Presentation
      Paris, France
    • Related Report
      2012 Annual Research Report
  • [Presentation] Gamma-glutamyltranspeptidase-specific fluorescent probe for the real-time identification of liver cancers

    • Author(s)
      Yoichi Miyata
    • Organizer
      The 10th world congress of International Hepato-pancreatic-biliary association
    • Place of Presentation
      Paris, France
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肝胆膵癌, 肝区域, 胆管, および膵液漏を描出するための術中蛍光イメージング技術の開発

    • Author(s)
      石沢 武彰
    • Organizer
      第25回 日本内視鏡外科学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] "No prophylactic drainage policy"に基づく腹腔鏡下肝切除342例(IMM, Paris)の手術成績の検討

    • Author(s)
      石沢 武彰
    • Organizer
      第67回 日本消化器外科学会総会
    • Place of Presentation
      富山
    • Related Report
      2012 Annual Research Report
  • [Presentation] 蛍光ナビゲーションを応用した鏡視下肝胆膵手術の開発

    • Author(s)
      石沢 武彰
    • Organizer
      第24回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] Indocyanine green蛍光法による肝細胞癌診断の機序解明と光線力学的治療への応用

    • Author(s)
      石沢 武彰
    • Organizer
      JDDW 2012
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] 病態解明のためのICG蛍光法:肝静脈閉塞領域の機能評価と肝癌手術診断法の基礎的検討

    • Author(s)
      石沢 武彰
    • Organizer
      第19回 血流動態イメージ研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 大腸癌転移に対する腹腔鏡下肝切除:部分切除から拡大右葉切除まで

    • Author(s)
      石沢 武彰
    • Organizer
      第12回 平成外科研究会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 蛍光観察が拓く腹腔鏡手術の新機軸 -基本と新しいアイディア-

    • Author(s)
      石沢 武彰
    • Organizer
      第67回 日本消化器外科学会総会
    • Place of Presentation
      富山
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 第67回 日本消化器外科学会総会

    • Author(s)
      石沢 武彰
    • Organizer
      第113回 日本外科学会総
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Fluorescent imaging : treatment of hepatobiliary and pancreatic diseases2013

    • Author(s)
      Kokudo N, Ishizawa T (eds.)
    • Publisher
      Karger, Basel
    • Related Report
      2013 Final Research Report
  • [Book] Fluorescent imaging: treatment of hepatobiliary and pancreatic diseases2013

    • Author(s)
      Kokudo N, Ishizawa T (Eds)
    • Total Pages
      124
    • Publisher
      Karger
    • Related Report
      2013 Annual Research Report
  • [Book] Gayet腹腔鏡下肝胆膵手術2012

    • Author(s)
      石沢武彰, Brice Gayet
    • Publisher
      南江堂,東京
    • Related Report
      2013 Final Research Report
  • [Book] Gayet腹腔鏡下肝胆膵手術2012

    • Author(s)
      Brice Gayet, 石沢 武彰(共著)
    • Total Pages
      173
    • Publisher
      南江堂
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 高感度膵液検出用蛍光プローブ、及び 膵液検出方法2013

    • Inventor(s)
      石沢武彰、山下俊、國土典宏、浦野 泰照、坂部雅世、長野哲雄
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-10-21
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 高感度膵液検出用蛍光プローブ、及び 膵液検出方法2013

    • Inventor(s)
      石沢武彰、山下俊、國土典宏、浦野 泰照、坂部雅世、長野哲雄
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-05-29
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 高感度膵液漏迅速検出法2013

    • Inventor(s)
      石沢武彰、國土典宏、浦野泰照、坂部雅世、山下俊、長野哲雄
    • Industrial Property Rights Holder
      石沢武彰、國土典宏、浦野泰照、坂部雅世、山下俊、長野哲雄
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-05-29
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 高感度膵液漏迅速検出法2012

    • Inventor(s)
      石沢武彰、山下俊、國土典宏、坂部雅世、長野哲雄、浦野泰照
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-123478
    • Filing Date
      2012-05-30
    • Related Report
      2012 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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