Functional recovery of spinal cord injury in the chondroitin sulfate-synthesizing enzymes
| Project/Area Number |
23700440
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 幹細胞生物学 / 再生 / 修復 / 軸索再生 / コンドロイチン硫酸 / 脊髄損傷 / 反応性グリア / グリア性瘢痕 / 行動解析 / ノックアウトマウス / 神経科学 / 神経発生 |
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| Research Abstract |
I analyzed the CNS of CSGalNAcT1(T1)-knockout mice (T1-KO).1) I postulated the compression model of spinal cord injury in T1-KO, and demonstrated better recovery in the functional and the histological aspects from SCI.2) The neural plasticity of the visual cortex showed that the critical period was not formed in T1-KO.3) T1 heterozygous mice showed the hyperactive social behavior and the lower social approach, indicating the abnormal higher functions in T1-KO.4) T1/T2-double knockout mice (DKO) were lethal at the embryonic stage.
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Report
(3 results)
Research Products
(12 results)
