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Analysis of glycan-related gene manipulated mice as new animal models of mental disease

Research Project

Project/Area Number 23700509
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Laboratory animal science
Research InstitutionKanazawa University

Principal Investigator

YOSHIHARA Toru  金沢大学, 子どものこころの発達研究センター, 特任助教 (00401935)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsノックアウトマウス / 糖鎖 / 精神疾患 / 糖転移酵素 / 行動解析 / マウス / 精神疾患モデル
Research Abstract

In this study, we focused on the functions of glycosyltransferases that acts as key factors in behavioral regulators. To reveal the relationships between those glycosyltransferases and human mental / neurological disease, we employed several strains of gene mamipulated mice and behavioral, histological and biochemical strategies were used. As result, 1) the knockout mouse related to the glycoprotein formation showed enhanced anxiety and disturbance of attention / sensory gating. 2) the knockout mouse related to the glycolipid formation showed severe motor disfunction and developmental retardation that could be explained by axonal disorganization. Therefore these behavioral phenotypes observed in several gene manipulated mice have similarities in human mental / neurological disease, we could confirm that these model mice are useful for the understanding of human disease.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2014 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (14 results)

  • [Journal Article] Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease.2014

    • Author(s)
      Lopatina O, Yoshihara T, Nishimura T, Zhong J, Akther S, Fakhrul AA, Liang M, Higashida C, Sumi K, Furuhara K, Inahata Y, Huang JJ, Koizumi K, Yokoyama S, Tsuji T, Petugina Y, Sumarokov A, Salmina AB, Hashida K, Kitao Y, Hori O, Asano M, Kitamura Y, Kozaka T, Shiba K, Zhong F, Xie MJ, Sato M, Ishihara K, Higashida H.
    • Journal Title

      Front Behav Neurosci

      Volume: 8 Pages: 1-18

    • DOI

      10.3389/fnbeh.2014.00133

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Displays of paternal mouse pup retrieval following communicative interaction with maternal mates2013

    • Author(s)
      Liu, H-X., Lopatina, O., Higashida, C., Fujimoto, H., Akther, S., Inzhutova, A., Liang, M., Zhong, J., Tsuji, T., Yoshihara, T., Sumi, K., Ishiyama, M., Ma, W-J., Ozaki, M., Yagitani, S., Yokoyama, S., Mukaida, N., Sakurai, T., Hori, O., Yoshioka, K., Hirao, A., Kato, Y., Ishihara, K., Kato, I., Okamoto, H., Cherepanov, S.M., Salmina, A.B., Hirai, H., Asano, M., Brown, D.A., Nagano, I., and Higashida, H.
    • Journal Title

      Nat. Commun

      Volume: 4 Issue: 1 Pages: 1346-1346

    • DOI

      10.1038/ncomms2336

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice2012

    • Author(s)
      Ito, M., Sugihara, K., Asaka, T., Toyama, T., Yo sh ih ar a, T., Furuichi, K., Wada, T. and Asano, M.
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 1 Pages: 1-13

    • DOI

      10.1371/journal.pone.0029873

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 4-galactosyltransferase-II and GlcAT-PFacilitates Biosynthesis of N-linked HNK-1Carbohydrate2011

    • Author(s)
      N. Nakagawa, T. Yoshihara, M. Asano, and S. Oka
    • Journal Title

      J. Biol. Chem

      Volume: 286(36) Issue: 36 Pages: 31337-46

    • DOI

      10.1074/jbc.m111.233353

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ラクトシルセラミド合成に関わるガラクトース転移酵素 β4GalT-5と-6欠損マウスの行動解析を中心とした脳・神経機能の解析2013

    • Author(s)
      吉原亨・佐武寛之・鈴木紘史・西江敏和・引持陽子・神村栄吉・沖野望・伊東信・古川鋼一・浅野雅秀
    • Organizer
      第36回分子生物学会年会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2013-12-05
    • Related Report
      2013 Final Research Report
  • [Presentation] ラクトシルセラミド合成に関わるガラクトース転移酵素群欠損マウスの行動解析と脳の組織学的・生化学的解析2013

    • Author(s)
      吉原亨・佐武寛之・鈴木紘史・西江敏和・引持陽子・神村栄吉・沖野望・伊東信・古川鋼一・浅野雅秀
    • Organizer
      第73回日本動物心理学会大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2013-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] ラクトシルセラミド合成に関わるガラクトース転移酵素群欠損マウスの行動解析と脳の組織学的・生化学的解析2013

    • Author(s)
      吉原亨・佐武寛之・鈴木紘史・西江敏和・引持陽子・神村栄吉・沖野望・伊東信・古川鋼一・浅野雅秀
    • Organizer
      第60回日本実験動物学会総会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2013-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] ラクトシルセラミド合成に関わるガラクトース転移 酵素群欠損マウスの行動解析と脳の組織学的・生化学的解析2013

    • Author(s)
      吉原 亨・佐武寛之・鈴木紘史・西江敏和・引持陽子・神村栄吉・沖野 望・伊 東 信・古川鋼一・浅野雅秀
    • Organizer
      第 60 回日本実験動物 学会総会
    • Place of Presentation
      つくば国際会議場,つくば,茨城
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラクトシルセラミド合成に関わるガラクトース転移 酵素群欠損マウスの行動解析と脳の組織学的・生化学的解析2013

    • Author(s)
      吉原 亨・佐武寛之・鈴木紘史・西江敏和・引持陽子・神村栄吉・沖野 望・伊 東 信・古川鋼一・浅野雅秀
    • Organizer
      第 73 回日本動物心理 学会大会
    • Place of Presentation
      筑波大学,つくば,茨城
    • Related Report
      2013 Annual Research Report
  • [Presentation] テストバッテリー方式によるコンドロイチン硫 酸鎖形成に関わる C6ST-1 トランスジェニックマウスの行動解析2013

    • Author(s)
      吉原 亨・北川裕之・浅野雅秀
    • Organizer
      第 36 回分子生物 学会年会
    • Place of Presentation
      神戸国際会議場,神戸,兵庫
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラクトシルセラミド合成に関わるガラクトース転移酵 素β4GalT-5 と-6 欠損マウスの行動解析を中心とした脳・神経機能の解析2013

    • Author(s)
      佐武寛之・吉原 亨・鈴木紘史・西江敏和・引持陽子・神村栄吉・沖野 望・伊 東 信・古川鋼一・浅野雅秀
    • Organizer
      第 36 回分子生物 学会年会
    • Place of Presentation
      神戸国際会議場,神戸,兵庫
    • Related Report
      2013 Annual Research Report
  • [Presentation] Reduction of lactosylceramide synthase activity and behavioral abnormalities in brain-specific β -galactosyltransferase-5-deficient mouse2012

    • Author(s)
      Yoshihara, T., Suzuki, H., Nishie, T., Hikimochi, Y., Kamimura, E., Okino, N., Ito, M. and Asano, M.
    • Organizer
      The 8th FENS Forum of Neuroscience
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2012-07-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳・神経系特異的β-1,4-ガラクトース転移酵素-5欠損マウスにおける活動性・注意機能の障害2012

    • Author(s)
      吉原亨,鈴木紘史,西江敏和,引持陽子,神村栄吉,沖野望,伊東信,浅野雅秀
    • Organizer
      第59回日本実験動物学会総会
    • Place of Presentation
      別府コンベンションセンター
    • Year and Date
      2012-05-25
    • Related Report
      2013 Final Research Report
  • [Presentation] Reduction of lactosylceramide synthase activity and behavioral abnormalities in brain-specific b4-galactosyltransferase-5-deficient mouse.2012

    • Author(s)
      Yoshihara, T., Suzuki, H., Nishie, T., Hikimochi, Y., Kamimura, E., Okino, N., Ito, M. and Asano, M.
    • Organizer
      The 8th FENS Forum of Neuroscience
    • Place of Presentation
      バルセロナ国際会議場,バルセロナ,スペイン
    • Related Report
      2012 Research-status Report
  • [Presentation] 脳・神経系特異的β-1,4-ガラクトース転移酵素-5欠損マウスにおけるミエリン鞘形成障害の検討2012

    • Author(s)
      吉原 亨,鈴木紘史,西江敏和,引持陽子,神村栄吉,沖野 望,伊東 信,浅野雅秀
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡,福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 脳・神経系特異的β-1,4-ガラクトース転移酵素-5欠損マウスにおける活動性・注意機能の障害2012

    • Author(s)
      吉原 亨,鈴木紘史,西江敏和,引持陽子,神村栄吉,沖野 望,伊東 信,浅野雅秀
    • Organizer
      第59回日本実験動物学会
    • Place of Presentation
      別府国際コンベンションセンター,大分
    • Related Report
      2012 Research-status Report
  • [Presentation] Analysis of brain function in neuron specific beta4-galactosyltransferase-5 deficient mouse by using behavioral test-battery2011

    • Author(s)
      鈴木紘史,吉原亨,西江敏和,引持陽子,神村栄吉,浅野雅秀
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 行動テストバッテリーによる神経特異的β4GalT-5欠損マウスの高次脳機能の解析2011

    • Author(s)
      鈴木紘史・吉原 亨・西江敏和・引持陽子・神村栄吉・浅野雅秀
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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