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Development of Multinuclear Synergism in Metal Cluster Catalyst

Research Project

Project/Area Number 23750049
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Organic chemistry
Research InstitutionKanazawa University

Principal Investigator

ENDO Kouhei  金沢大学, 物質化学系, 准教授 (70454064)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords有機合成化学 / 有機金属化学 / 分子触媒 / 不斉合成 / 触媒 / 金属錯体 / 原子集導体 / クラスター / 協同作用 / 複核金属錯体
Research Abstract

The present study describes the generation of synergistic intermediates derived from multinuclear complexes in organic reactions. Typically, organic chemistry focuses on the development of simple reactive intermediates due to the disadvantageous using complicated molecules. The original strategies for the construction of “complicated reactive intermediates in situ” were achieved during our course of study. The synergistic effects realized the unprecedented control of organic reactions, which could not be achieved with the conventional systems.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (47 results)

All 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (35 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Effect of Multinuclear Cu/Al-Complexes in Highly Asymmetric Conjugate Addition of Trimethylaluminum to Acyclic Enones2013

    • Author(s)
      Endo, K.*; Hamada, D.; Yakeishi, S.; Shibata, T.*
    • Journal Title

      Angew. Chem. Int. Ed/highlighted by Synfacts 2013

      Volume: 52/299 Issue: 2 Pages: 606-610

    • DOI

      10.1002/anie.201206297

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-Pot Synthesis of Symmetrical and Unsymmetrical Diarylmethanes via Diborylmethane2012

    • Author(s)
      Endo, K.*; Ishioka, T.; Ohkubo, T.; Shibata, T.*
    • Journal Title

      J. Org. Chem

      Volume: 77 Issue: 17 Pages: 7223-7231

    • DOI

      10.1021/jo3015165

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cross Coupling between sp3-Carbon and sp3-Carbon Using a Diborylmethane Derivative at Room Temperature2012

    • Author(s)
      Kohei Endo, Takahiro Ohkubo, Takafumi Ishioka, Takanori Shibata
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 77 Issue: 10 Pages: 4826-4831

    • DOI

      10.1021/jo3004293

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multinuclear Cu-Catalysts Based on SPINOL-PHOS in Asymmetric Conjugate Addition of Organozinc Reagents2012

    • Author(s)
      Kohei Endo, Daisuke Hamada, Sayuri Yakeishi, Mika Ogawa, Takanori Shibata
    • Journal Title

      Organic Letters

      Volume: 14 Issue: 9 Pages: 2342-2345

    • DOI

      10.1021/ol300748d

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detour and Direct Induction of Methyl-Containing Chiral Centers via Catalytic C-H or C-C Bond Formation2012

    • Author(s)
      Endo, K.*; Shibata, T.*
    • Journal Title

      Synthesis

      Volume: 44 Issue: 10 Pages: 1427-1452

    • DOI

      10.1055/s-0031-1290869

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Synthesis of Allylsilanes Bearing Tetrasubstituted Olefin via 2,2-Diborylethylsilane2011

    • Author(s)
      Endo, K.*; Sakamoto, A.; Ohkubo, T.; Shibata, T.*
    • Journal Title

      Chem. Lett

      Volume: 40 Issue: 12 Pages: 1440-1442

    • DOI

      10.1246/cl.2011.1440

    • NAID

      10030221712

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemoselective Suzuki Coupling of Diborylmethane for Facile Synthesis of Benzylboronates2011

    • Author(s)
      Endo, K.*; Ohkubo, T.; Shibata, T.*
    • Journal Title

      Org. Lett

      Volume: 13 Issue: 13 Pages: 3368-3371

    • DOI

      10.1021/ol201115k

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Development of Multinuclear Catalyst Using BINAM-PHOS for Cu-Catalyzed Asymmetric Conjugate Addition of Organometallic Reagents2013

    • Author(s)
      Ryotaro Takayama, Kohei Endo, Takanori Shibata
    • Organizer
      The 4thSymposium on Chiral Science & Technology
    • Place of Presentation
      早稲田大学,東京都
    • Year and Date
      2013-03-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 複核銅触媒による4級不斉炭素原子をα位に有する不飽和ラクトンの立体選択的合成2013

    • Author(s)
      焼石さゆり,遠藤恆平,柴田高範
    • Organizer
      日本化学会大93春季年会
    • Place of Presentation
      立命館大学,滋賀県
    • Related Report
      2012 Final Research Report
  • [Presentation] 複核銅触媒による4級不斉炭素原子をα位に有する不飽和ラクトンの立体選択的合成2013

    • Author(s)
      焼石さゆり、遠藤恆平、柴田高範
    • Organizer
      日本化学会 第93春季年会
    • Place of Presentation
      立命館大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] BINAM骨格を有する新規な複核金属錯体の開発:銅触媒による有機金属試薬の不斉共役付加反応2012

    • Author(s)
      高山遼太郎,遠藤恆平,柴田高範
    • Organizer
      日本化学会 第92春季年会
    • Place of Presentation
      慶応義塾大学,神奈川県
    • Year and Date
      2012-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] SPINOL-PHOS配位子を用いる銅触媒による有機アルミニウム試薬の触媒的不斉共役付加反応の開発2012

    • Author(s)
      浜田大輔,遠藤恆平,柴田高範
    • Organizer
      日本化学会 第92春季年会
    • Place of Presentation
      慶応義塾大学,神奈川県
    • Year and Date
      2012-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] BINOL-mono-PHOSを用いる複核銅触媒による有機金属試薬の触媒的不斉共役付加反応の開発2012

    • Author(s)
      焼石さゆり,浜田大輔,遠藤恆平,柴田高範
    • Organizer
      日本化学会 第92春季年会
    • Place of Presentation
      慶応義塾大学,神奈川県
    • Year and Date
      2012-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 高効率的触媒反応における多点反応場協同作用の精密設計2012

    • Author(s)
      遠藤恆平
    • Organizer
      日本化学会 第92春季年会
    • Place of Presentation
      慶応義塾大学,神奈川県
    • Year and Date
      2012-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] ジボリルメタンを用いる連続的鈴木宮浦クロスカップリング反応によるジアリールメタンのワンポット合成2012

    • Author(s)
      石岡孝文,大久保貴弘,遠藤恆平,柴田高範
    • Organizer
      日本化学会 第92春季年会
    • Place of Presentation
      慶応義塾大学,神奈川県
    • Year and Date
      2012-03-25
    • Related Report
      2012 Final Research Report
  • [Presentation] ジボリルメタンを用いた室温条件下におけるsp3 炭素原子上での化学選択的な鈴木宮浦クロスカップリング反応の開発2012

    • Author(s)
      大久保貴弘,遠藤恆平,柴田 高 範
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶応義塾大学,神奈川県
    • Year and Date
      2012-03-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Multinuclear Cu-Catalysts Based on BINOL-PHOS Ligands in Asymmetric Conjugate Addition of Organometallic Reagents2012

    • Author(s)
      焼石さゆり,遠藤恆平,柴田高範
    • Organizer
      Symposium on Molecular Chirality ASIA 2012
    • Place of Presentation
      九州大学,福岡県
    • Related Report
      2012 Final Research Report
  • [Presentation] Cu-Catalyzed Asymmetric Conjugate Addition of Organometallic Reagents Using Multinuclear Complex Based on BINAM-PHOS2012

    • Author(s)
      Ryotaro Takayama, Kohei Endo, Takanori Shibata
    • Organizer
      IKCOC 12
    • Place of Presentation
      京都府
    • Related Report
      2012 Final Research Report
  • [Presentation] ne-Pot Suzuki-Miyaura Cross-Coupling of Diborylmethane for the Synthesis of Diarylmethanes2012

    • Author(s)
      Takafumi Ishioka, Kohei Endo, Takanori Shibata
    • Organizer
      IKCOC 12
    • Place of Presentation
      京都府
    • Related Report
      2012 Final Research Report
  • [Presentation] Multinuclear Catalysts based on BINOL for Copper-Catalyzed Asymmetric Conjugate Addition of Organoaluminum Reagents2012

    • Author(s)
      Sayuri Yakeishi, Kohei Endo, Takanori Shibata
    • Organizer
      International Conference on Organometallic Chemistry 2012
    • Place of Presentation
      Lisbon University (Portugal)
    • Related Report
      2012 Final Research Report
  • [Presentation] Multinuclear Cu-Catalysts Based on BINOL-PHOS Ligands in Asymmetric Conjugate Addition of Organometallic Reagents2012

    • Author(s)
      焼石さゆり、遠藤恆平、柴田高範
    • Organizer
      Symposium on Molecular Chirality ASIA 2012
    • Place of Presentation
      九州大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cu-Catalyzed Asymmetric Conjugate Addition of Organometallic Reagents Using Multinuclear Complex Based on BINAM-PHOS2012

    • Author(s)
      Ryotaro Takayama, Kohei Endo, Takanori Shibata
    • Organizer
      IKCOC 12
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Takafumi Ishioka, Kohei Endo, Takanori Shibata2012

    • Author(s)
      One-Pot Suzuki-Miyaura Cross-Coupling of Diborylmethane for the Synthesis of Diarylmethanes
    • Organizer
      IKCOC 12
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Multinuclear Catalysis based BINOL for Copper-Catalyzed Asymmetric Conjugate Addition of Organoaluminum Reagents2012

    • Author(s)
      Sayuri Yakeishi, Kohei Endo, Takanori Shibata
    • Organizer
      International Conference on Organometallic Chemistry 2012
    • Place of Presentation
      Lisbon University(Portugal)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Multinuclear Cu-Catalysts Based on BINOL-PHOS Ligands in Asymmetric Conjugate Addition of Organometallic Reagents2012

    • Author(s)
      Sayuri Yakeishi, Kohei Endo, Takanori Shibata
    • Organizer
      Symposium on Molecular Chirality ASIA 2012
    • Place of Presentation
      Centennial Hall Kyushu University School of Medicine(Fukuoka)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高効率的触媒反応における多点反応場協同作用の精密設計2012

    • Author(s)
      遠藤恆平
    • Organizer
      日本化学会第92春季年会 若い世代の特別講演会
    • Place of Presentation
      慶応大学矢上キャンパス、神奈川県
    • Related Report
      2011 Research-status Report
  • [Presentation] ジボリルメタンを用いた室温条件下におけるsp3 炭素原子上での化学選択的な鈴木宮浦クロスカップリング反応の開発2012

    • Author(s)
      ○大久保貴弘・遠藤恆平・柴田高範
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶応大学矢上キャンパス、神奈川県
    • Related Report
      2011 Research-status Report
  • [Presentation] ジボリルメタンを用いる連続的鈴木宮浦クロスカップリング反応によるジアリールメタンのワンポット合成2012

    • Author(s)
      ○石岡孝文・大久保貴弘・遠藤恆平・柴田 高範
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶応大学矢上キャンパス、神奈川県
    • Related Report
      2011 Research-status Report
  • [Presentation] BINOL-mono-PHOSを用いる複核銅触媒による有機金属試薬の触媒的不斉共役付加反応の開発2012

    • Author(s)
      ○焼石さゆり・浜田大輔・遠藤恆平・柴田高範
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶応大学矢上キャンパス、神奈川県
    • Related Report
      2011 Research-status Report
  • [Presentation] SPINOL-PHOS配位子を用いる銅触媒による有機アルミニウム試薬の触媒的不斉共役付加反応の開発2012

    • Author(s)
      ○浜田大輔・遠藤恆平・柴田高範
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶応大学矢上キャンパス、神奈川県
    • Related Report
      2011 Research-status Report
  • [Presentation] BINAM骨格を有する新規な複核金属錯体の開発:銅触媒による有機金属試薬の不斉共役付加反応2012

    • Author(s)
      ○高山遼太郎・遠藤恆平・柴田高範
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶応大学矢上キャンパス、神奈川県
    • Related Report
      2011 Research-status Report
  • [Presentation] マルチボリルメタンを用いるカップリング反応2011

    • Author(s)
      遠藤恆平
    • Organizer
      第8回触媒相模セミナー
    • Place of Presentation
      相模中央化学研究所,神奈川県
    • Year and Date
      2011-11-17
    • Related Report
      2012 Final Research Report
  • [Presentation] クラスター精密設計を目指した触媒反応制御2011

    • Author(s)
      遠藤恆平
    • Organizer
      京都大学 第5回GCOE 有機若手セミナー
    • Place of Presentation
      京都大学,京都府
    • Year and Date
      2011-09-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Design and Syntheses of Cluster Molecules in Catalytic Reactions2011

    • Author(s)
      Kohei Endo
    • Organizer
      National University of Singapore
    • Place of Presentation
      Singapore
    • Year and Date
      2011-06-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Design and Syntheses of Cluster Molecules in Catalytic Reactions2011

    • Author(s)
      Kohei Endo
    • Organizer
      Nanyang Technological University
    • Place of Presentation
      Singapore
    • Year and Date
      2011-06-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 1,1-ジボリルアルカンを用いる室温条件下におけるsp3炭素原子上での化学選択的/位置特異的鈴木宮浦クロスカップリング反応2011

    • Author(s)
      遠藤恆平
    • Organizer
      第99回有機合成シンポジウム
    • Place of Presentation
      慶応義塾大学,東京都
    • Year and Date
      2011-06-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 1,1-ジボリルアルカンを用いる室温条件下におけるsp3炭素上での化学選択的/位置特異的鈴木宮浦クロスカップリング反応2011

    • Author(s)
      遠藤恆平
    • Organizer
      第99回 有機合成シンポジウム
    • Place of Presentation
      慶応大学芝共立キャンパス、東京都
    • Related Report
      2011 Research-status Report
  • [Presentation] Design and Syntheses of Cluster Molecules in Catalytic Reactions2011

    • Author(s)
      Kohei Endo
    • Organizer
      シンガポール(招待講演)
    • Place of Presentation
      Nanyang Technological University、シンガポール
    • Related Report
      2011 Research-status Report
  • [Presentation] Design and Syntheses of Cluster Molecules in Catalytic Reactions2011

    • Author(s)
      Kohei Endo
    • Organizer
      シンガポール(招待講演)
    • Place of Presentation
      National University of Singapore、シンガポール
    • Related Report
      2011 Research-status Report
  • [Presentation] クラスター精密設計を目指した触媒反応制御2011

    • Author(s)
      遠藤恆平
    • Organizer
      京都大学 第5回 GCOE 有機若手セミナー(招待講演)
    • Place of Presentation
      京都大学、京都府
    • Related Report
      2011 Research-status Report
  • [Presentation] マルチボリルメタンを用いるカップリング反応2011

    • Author(s)
      遠藤恆平
    • Organizer
      第8回触媒相模セミナー(招待講演)
    • Place of Presentation
      相模中央化学研究所、神奈川県
    • Related Report
      2011 Research-status Report
  • [Presentation] Development of Multinuclear Catalyst Using BINAM-PHOS for Cu-Catalyzed Asymmetric Conjugate Addition of Organometallic Reagents

    • Author(s)
      Ryotaro Takayama, Kohei Endo, Takanori Shibata
    • Organizer
      The 4Th Symposium on Chiral Science & Technology
    • Place of Presentation
      早稲田大学
    • Related Report
      2012 Annual Research Report
  • [Book] 触媒の設計・反応制御 事例集2013

    • Author(s)
      遠藤恆平(一部執筆)
    • Total Pages
      827
    • Publisher
      技術情報協会
    • Related Report
      2012 Final Research Report
  • [Book] 触媒の設計・反応制御 事例集2013

    • Author(s)
      遠藤恆平
    • Total Pages
      827
    • Publisher
      技術情報協会
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://endorg.secret.jp

    • Related Report
      2012 Final Research Report
  • [Remarks] ENDO Research Group

    • URL

      http://endorg.secret.jp

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://endorg.com/

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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