| Project/Area Number |
23791246
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
HONMA Masaru 旭川医科大学, 医学部, 講師 (50344578)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 表皮角化細胞 / 有棘細胞癌 / 皮膚癌 / 幹細胞 / 分化 / 角化 / 浸潤能 / 遊走能 / 乾癬 / ポドプラニン / インテグリン / アデノウィルスベクター / 細胞遊走 |
|---|
| Research Abstract |
Our results of epidermal keratinocytes show that podoplanin is associated with the regulatory mechanism of cell adhesion and self-renewal potency. This mechanism reflects both increased proliferating pool and increased transition into differentiation process of keratinocytes in prosiatic epidermis. In addition, we revealed the novel cell density-dependent PDPN-induction mechanism in squamous cell carcinoma cell-lines, which might play an important role in tumor progression process.
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