Identification of synovial sarcoma initiating cells
Project/Area Number |
23791621
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Hokkaido University |
Principal Investigator |
KIMURA Taichi 北海道大学, 大学院・医学研究科, 助教 (90435959)
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Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 滑膜肉腫 / 腫瘍幹細胞 / 新規治療標的分子 |
Research Abstract |
We demonstrated that the cell surface antigen A is highly expressed in the sphere forming subpopulation of synovial sarcoma and correlate with the expression of stemness genes. Antigen A positive cells possessed high tumorigenic, self-renewing, and re-popularizing activity; therefore we concluded that the Antigen A can enrich synovial sarcoma initiating cells. By immunohistochemical analysis of 42 synovial sarcoma surgical specimens, Antigen A expression was well correlated with poor prognosis. Moreover, the specific inhibitor of antigen A could suppress the proliferation of synovial sarcoma cell-lines in vitro. In this study, we first detect synovial sarcoma initiating cells and a specific marker, and these findings play a very important role about exploitation the new therapy against synovial sarcoma.
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Report
(3 results)
Research Products
(48 results)
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[Journal Article] Inhibition of GSH synthesis potentiates temozolomide-induced bystander effect in glioblastoma2013
Author(s)
Kohsaka, S., Takahashi, K., Tanino, M., Kimura, T., Nishihara, H., Tanaka, S
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Journal Title
Cancer Letter
Volume: 331(1)
Pages: 68-75
Related Report
Peer Reviewed
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[Journal Article] Downregulation of miRNA-31 induces taxane resistance in ovarian cancer cells through increase of receptor tyrosinekinase MET2013
Author(s)
Mitamura T., Watari H., Wang L., Kanno H., Hassan MK.,Miyazaki M.,Katoh Y., Kimura T., Tanino M., NishiharaH., Tanaka S., Sakuragi N
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Related Report
Peer Reviewed
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[Journal Article] STAT3 inhibition overcomes temozolomide resistance in glioblastoma by downregulating MGMT expression2012
Author(s)
Kohsaka, S., Wang, L., Yachi, K., Mahabir, R., Narita, T., Itoh, T., Tanino, M., Kimura, T., Nishihara H., Tanaka, S
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Journal Title
Mol Cancer Ther
Volume: 11
Pages: 1289-1299
NAID
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Peer Reviewed
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[Journal Article] CD133 negatively regulates tumorigenicity via AKT pathway in synovial sarcoma2012
Author(s)
Kimura, T., Wang, L., Tabu, K., Nishihara, H., Mashita, Y., Kikuchi, N., Tanino, M., Hiraga, H., Tanaka, S
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Journal Title
Cancerinvest
Volume: 30
Pages: 390-397
NAID
Related Report
Peer Reviewed
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[Journal Article] Prognostic implication of histological oligodendroglial tumor component: clinicopathological analysis of 111 cases of malignant gliomas2012
Author(s)
Kanno, H., Nishihara, H., Narita, T., Yamaguchi, S., Kobayashi, H., Tanino, M., Kimura, T., Terasaka S., Tanaka, S
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] CRKL plays a pivotal role intumorigenesis of head and neck squamous cell carcinoma through the regulation of cell adhesion2012
Author(s)
Yanagi, H.,Wang, L.,Nishihara, H., Kimura, T., Tanino, M.,Yanagi, T.,Fukuda, S.,Tanaka, S
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Journal Title
Biochem Biophys Res Commun
Volume: 418
Pages: 104-109
Related Report
Peer Reviewed
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[Journal Article] Successful transplantation of rat hearts subjected to extended cold preservation with a novel preservation solution2012
Author(s)
Wakayama, K.,Fukai, M.,Yamashita, K.,Kimura, T.,Hirokata, G.,Shibasaki, S.,Fukumori, D.,Haga, S. Sugawara, M.,Suzuki, T.,Taniguchi, M.,Shimamura, T.,Furukawa, H.,Ozaki, M.,Kamiyama, T.,Todo, S
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Journal Title
Transpl Int
Volume: 25
Pages: 696-706
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Peer Reviewed
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[Journal Article] Prognostic implication of histological oligodendroglial tumor component: clinicopathological analysis of 111 cases of malignant gliomas.2012
Author(s)
Kanno, H.,Nishihara, H.,Narita, T.,Yamaguchi, S.,Kobayashi, H.,Tanino, M.,Kimura, T.,Terasaka S.,Tanaka, S.
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Journal Title
PLoS One.
Volume: 7
Issue: 7
Pages: e41669-e41669
DOI
NAID
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Peer Reviewed
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[Journal Article] Expression of O6-methylguanine DNA methyltransferase (MGMT) and immunohistochemical analysis of 12 pineal parenchymal tumors.2012
Author(s)
Kanno, H.,Nishihara, H.,Oikawa, M.,Ozaki, Y.,Murata, J.,Sawamura, Y.,Kato, M.,Kubota, K.,Tanino, M. Kimura, T.,Nagashima, K.,Itoh, T.,Tanaka, S.
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Journal Title
Neuropathology
Volume: 32
Issue: 6
Pages: 647-653
DOI
NAID
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Peer Reviewed
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[Journal Article] A case of atypical teratoid/rhabdoid tumor in an adult, with long survival2011
Author(s)
Takahashi, K., Nishihara, H., Katoh, M., Yoshinaga, T., Mahabir, R., Kanno, H., Kimura, T., Tanino, M., Ikeda, J., Sawamura, Y., Nagashima, K., Tanaka. S
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Journal Title
Brain Tumor Pathol
Volume: 28
Issue: 1
Pages: 71-6
DOI
Related Report
Peer Reviewed
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[Journal Article] Prenatal diagnosis of short-rib polydactyly syndrome type 3 (Verma-Naumoff type) by three-dimensional helical computed tomography.2011
Author(s)
Yamada T, Nishimura G, Nishida K, Sawai H, Omatsu T, Kimura T, Nishihara H, Shono R, Shimada S, Morikawa M, Mizushima M, Yamada T, Cho K, Tanaka S, Shirato H, Minakami H.
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Journal Title
J Obstet Gynaecol Res.
Volume: 37
Issue: 2
Pages: 151-155
DOI
NAID
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Peer Reviewed
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[Presentation] from tissues to therapeutic reagents2012
Author(s)
Shinya Tanaka, Shinji Kohsaka, Kouich Tabu, Lei Wang, Masumi Tsuda, Taichi Kimura, Mishie Tanino, Hiroshi Nishihara, Hiromichi Kimura: Molecular and pathological analysis of malignant glioma
Organizer
第71回日本癌学会学術総会
Place of Presentation
ロイトン札幌ほか(札幌)
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