The mechanism of cleft palate after palatal fusion -Effect of MEOX2-
Project/Area Number |
23792394
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Aichi Gakuin University |
Principal Investigator |
IMURA HIDETO 愛知学院大学, 歯学部, 非常勤講師 (10513187)
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Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 口蓋裂 / 発生 / MEOX2 / 離開 / MEOX2 / 離解 / 遺伝子 |
Research Abstract |
Cleft palate must therefore be induced by a disruption during the developmental process of the palatal shelves. We reported that some embryos appeared to develop cleft palates after palatal fusion by TCDD.On the other hand, the same present status has been reported in mesenchyme homeobox 2(Meox2) knockout mouse. We observed MEOX2 gene from the blood of the patient of a human cleft palate.Sequence analysis was conducted to 99 Japanese cleft palate patients. Candia et al. reported that the MEOX2 gene is expressed in a wide range of mesodermal structures, including the developing limbs, groups of muscles of the head, and the developing palate. Mankoo et al. reported that MEOX2 was essential for normal muscle formation and for the normal regulation of myogenic genes, as demonstrated by the downregulation of Pax3.A possibility that the variation of MEOX2 had affected by vulnerability of palatal muscle after palatal fusion was suggested.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Beckwith-Wiedemann症候群の臨床的研究―インプリント遺伝子解析と臨床経過を中心として―2014
Author(s)
加藤大貴, 井村英人, 東元健, 八木ひとみ, 芝崎龍典, 古川博雄, 新美照幸, 藤原久美子, 鈴木聡, 外山佳孝, 南克浩, 井上知佐子, 早川統子, 副島英伸, 夏目長門
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Journal Title
日本口蓋裂学会雑誌
Volume: 39(1)
Pages: 21-27
NAID
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[Journal Article] Replication of genome wide association identified candidate genes confirm the role of common and rare variants in PAX7 and VAX1 in the etiology of nonsyndromic CL(P)2013
Author(s)
Butali A, Suzuki S, Cooper ME, Mansilla AM, Cuenco K, Leslie EJ, Suzuki Y, Niimi T, Yamamoto M, Ayanga G, Erkhembaatar T, Furukawa H, Fujiwawa K, Imura H, Petrin AL, Natsume N, Beaty TH, Marazita ML, Murray JC
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Journal Title
Am J Med Genet A
Volume: 161A(5)
Pages: 965-972
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[Journal Article] 口蓋裂術後声門破裂音に対する一般人の聴覚印象評価に関する研究2012
Author(s)
古川 博雄, 早川 統子, 片山 和男, 加藤 大貴, 井村 英人, 堀内 隆作, 井上 知佐子, 牧野 日和, 森 智子, 伊藤 美知恵, 夏目 長門
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Journal Title
愛知学院大学歯学会誌
Volume: 50巻2号
Pages: 53-58
NAID
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Peer Reviewed
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[Journal Article] 先天性側方上唇瘻孔と鼻瘻孔が合併した右側口唇顎裂の1例2012
Author(s)
加藤 大貴, 藤原 久美子, 古川 博雄, 新美 照幸, 外山 佳孝, 長瀬 好和, 麻生 昌邦, 井村 英人, 南 克浩, 大野 磨弥, 夏目 長門
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Journal Title
日本口蓋裂学会雑誌
Volume: 37巻1号
Pages: 44-48
NAID
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Peer Reviewed
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[Journal Article] 認知症と日常生活動作の自発性および舌苔付着との関連 老人保健施設における認知症と自発性、舌苔との関連調査報告2012
Author(s)
牧野 日和, 井村 英人, 早川 統子, 古川 博雄, 長瀬 好和, 岩田 睦代, 諸田 真澄, 年盛 満恵, 瀬戸 千尋, 加藤 大貴, 井上 知佐子, 相原 喜子, 外山 佳孝, 夏目 長門
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Journal Title
日本口腔ケア学会雑誌
Volume: 6巻1号
Pages: 51-57
NAID
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Peer Reviewed
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[Presentation] 口唇口蓋裂を認めたoral-facial-digital syndromeの一例2013
Author(s)
井村英人, 鈴木聡, 新美照幸, 藤原久美子, 南克浩, 古川博雄, 加藤大貴, 大野磨弥, 森明弘, 森智子, 菅原利夫, 夏目長門
Organizer
日本口蓋裂学会
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[Presentation] 口唇口蓋裂児の哺乳に関する研究(第1報) 酸素飽和度低下を来した症例2012
Author(s)
井村 英人, 牧志 祥子, 藤原 久美子, 新美 照幸, 南 克浩, 古川 博雄, 加藤 大貴, 大野 磨弥, 佐藤 孝至, 杉山 成司, 夏目 長門
Organizer
日本口蓋裂学会総会・学術大会
Place of Presentation
京都
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