Relationship between Mucosal Immune Response to Phosphorylcholineand atherosclerosis

• Project/Area Number: 23792515
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: GOTO Masaki 徳島大学, 大学院・ソシオテクノサイエンス研究部, 助教 (30507455)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 粘膜免疫 / ホスホリルコリン / 動脈硬化 / 口腔常在菌

Research Abstract

Antibody levels in sera and mucosal secretions following the nasal vaccination with PC-KLH were facilitated by coadministration of LPS. LPS can be used as a mucosal adjuvant as an alternative to CT. From an epidemiological survey, antibody levels of the huma n anti-PC IgM in plasma associated with the risk for the atherosclerosis but the periodontal condition must be considered in analysis of the atherosclerosis.

Research Products

• [Journal Article] Study on the Subgel-Phase Formation Using an Asymmetric Phospholipid Bilayer Membrane by High-Pressure Fluorometry (2012)
  • Author(s): Masaki Goto
  • Journal Title: Langmuir Volume: 28 Issue: 33 Pages: 12191-12198
  • DOI: 10.1021/la3020173
  • Peer Reviewed
• [Journal Article] Mucosal immune features to phosphorylcholine by nasal Flt3 ligand cDNA-based vaccination (2011)
  • Author(s): Baatarjav T., et al
  • Journal Title: Vaccine Volume: 29 Issue: 34 Pages: 5747-5767
  • DOI: 10.1016/j.vaccine.2011.05.097
  • Peer Reviewed
• [Presentation] Relationship between atherosclerosis and anti-phosphorylcholine antibodies in saliva and plasma (2012)
  • Author(s): M. Fukui
  • Organizer: 10th International Conference of AsianAcademy of Preventive Dentistry
  • Place of Presentation: Mongolian Government Palace, Conference hall (Mongolia)
  • Year and Date: 2012-09-14
• [Presentation] 動脈硬化リスク評価のための唾液・血液中の抗ホスホリルコリン抗体の測定 (2012)
  • Author(s): 福井誠
  • Organizer: 第5回日本口腔検査学会総会・学術大会
  • Place of Presentation: 日本大学(東京都)
  • Year and Date: 2012-08-25
• [Presentation] ヒト唾液中および血中の抗ホスホリルコリン抗体と動脈硬化リスクとの関連性-第二報- (2012)
  • Author(s): 福井誠
  • Organizer: 第61回日本口腔衛生学会・総会
  • Place of Presentation: 神奈川歯科大学(神奈川県)
  • Year and Date: 2012-05-25
• [Presentation] ヒト唾液中および血中の抗ホスホリルコリン抗体と動脈硬化リスクとの関連性－第二報－ (2012)
  • Author(s): 福井誠
  • Organizer: 第61回日本口腔衛生学会・総会
  • Place of Presentation: 神奈川歯科大学（神奈川）
• [Presentation] 動脈硬化リスク評価のための唾液・血液中の抗ホスホリルコリン抗体の測定 (2012)
  • Author(s): 福井誠
  • Organizer: 第5回日本口腔検査学会総会・学術大会
  • Place of Presentation: 日本大学（東京）
• [Presentation] Relationship between atherosclerosis and anti-phosphorylcholine antibodies in saliva and plasma (2012)
  • Author(s): Makoto Fukui
  • Organizer: 10th International Conference of Asian Academy of Preventive Dentistry
  • Place of Presentation: Mongolian Government Palace, Conference hall (Mongolia)
• [Presentation] ヒト唾液中および血中の抗ホスホコリン抗体と動脈硬化リスクとの関連性:五島研究 (2011)
  • Author(s): 福井 誠
  • Organizer: 第60回日本口腔衛生学会
  • Place of Presentation: 日本大学松戸歯学部(千葉県)
  • Year and Date: 2011-10-09
• [Presentation] 経鼻粘膜アジュバント CpG ODN はマクロファージの TLR9 発現と歯周病原細菌抗原特異的 Th1 免疫応答を誘導する (2011)
  • Author(s): サプタ・ムルヤトノ
  • Organizer: 第60回日本口腔衛生学会
  • Place of Presentation: 日本大学松戸歯学部(千葉県)
  • Year and Date: 2011-10-09
• [Presentation] ヒト唾液中および血中の抗ホスホリルコリン抗体と動脈硬化リスクとの関連性：五島研究 (2011)
  • Author(s): 福井 誠
  • Organizer: 第60回日本口腔衛生学会
  • Place of Presentation: 日本大学松戸歯学部（千葉県）
• [Presentation] 経鼻粘膜アジュバントCpG ODNはマクロファージのTLR9発現と歯周病原細菌抗原特異的Th1免疫応答を誘導する (2011)
  • Author(s): ムルヤトノ・サプタ
  • Organizer: 第60回日本口腔衛生学会
  • Place of Presentation: 日本大学松戸歯学部（千葉県）