Spatiotemporal control mechanisms of neural circuit formation
Project/Area Number |
24300116
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Neuroscience in general
|
Research Institution | Chiba University |
Principal Investigator |
SAITO Tetsuichiro 千葉大学, 医学(系)研究科(研究院), 教授 (00202078)
|
Co-Investigator(Kenkyū-buntansha) |
MUROYAMA Yuko 千葉大学, 大学院医学研究院, 特任講師 (20422248)
SATO Tatsuya 千葉大学, 大学院医学研究院, 助教 (00568222)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
Keywords | 遺伝子 / 細胞・組織 / 神経科学 / 脳・神経 / 発生・分化 / 脊髄 / 神経細胞 / 電気穿孔法 / テトラサイクリン |
Outline of Final Research Achievements |
Neural circuit formation requires fine spatiotemporal control of each step, such as neuronal differentiation and axonal projection. We have developed a new method in which gene expression is turned on in an aimed portion of the mouse nervous system in vivo. Mice that have a defect in a restricted part of neural circuits and a specific behavioral disorder have been efficiently obtained.
|
Report
(4 results)
Research Products
(17 results)