The analysis of a novel intracellular signaling pathway to evaluate estrogenic chemicals
Project/Area Number |
24310050
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Risk sciences of radiation/Chemicals
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Research Institution | National Institute of Advanced Industrial Science and Technology |
Principal Investigator |
KIYAMA Ryoiti 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 上級主任研究員 (00240739)
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Co-Investigator(Renkei-kenkyūsha) |
SAKUMA Yasuo 日本医科大学, 医学系研究科, 教授 (70094307)
KANEDA Makoto 日本医科大学, 医学系研究科, 教授 (30214480)
KIYAMA Yuko 日本医科大学, 医学系研究科, 准教授 (60234390)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
Keywords | エストロゲン / シグナル伝達系 / 化学物質管理評価 / 環境物質 / 膜共役系 / 受容体 / 遺伝子機能 / 天然物 / シグナル伝達経路 |
Outline of Final Research Achievements |
We analyzed a novel estrogen responsive non-genomic pathway, which is different from the conventional genomic pathway, by focusing on the intracellular signaling pathways and its relationship with cell functions, such as cell growth and movement, and cell physiology, such as sexual differentiation. We found a new estrogenic signaling cascade, which does not involve cell proliferation, from the analysis of natural products, and based on the information obtained, we pursued applications of new estrogenic chemicals for development of pharmaceuticals and production of functional foods.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Development of pathological diagnostics of human kidney cancer by multiple staining using new fluorescent Fluolid dyes.2014
Author(s)
Wuxiuer, D., Yun Zhu, Y., Ogaeri, T., Mizuki, K., Kashiwa, Y., Nishi, K., Isobe, S.-i., Aoyagi, T.-i., and Kiyama, R.
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Journal Title
BioMed Res. Int.
Volume: 2014
Pages: 437871-437871
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Brefeldin A is an estrogenic, Erk1/2-activating component in the extract of Agaricus blazei mycelia.2013
Author(s)
Dong S1, Furutani Y, Kimura S, Zhu Y, Kawabata K, Furutani M, Nishikawa T, Tanaka T, Masaki T, Matsuoka R, Kiyama R
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Journal Title
J Agric Food Chem
Volume: 61
Issue: 1
Pages: 128-136
DOI
Related Report
Peer Reviewed
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[Journal Article] Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract2012
Author(s)
Dong, S., Furutani, Y., Suto, Y., Furutani, M., Zhu, Y., Yoneyama, M., Kato, T., Itabe, H., Nishikawa, T., Tomimatsu, H., Tanaka, T., Kasanuki, H., Masaki, T., Kiyama, R. and Matsuoka, M.
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Journal Title
Microbiol. Res
Volume: 167
Issue: 4
Pages: 231-237
DOI
Related Report
Peer Reviewed
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[Journal Article] Evaluation of cellular response to perfluorooctane sulfonate in human umbilical vein endothelial cells2012
Author(s)
Liao, Y., Wang, J., Huang, Q.-s, Fang, C., Kiyama, R., Shen, H., Sijun Dong, S.
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Journal Title
Toxicol.In Vitro
Volume: 26
Issue: 3
Pages: 421-428
DOI
Related Report
Peer Reviewed
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