Validation for adequacy of serum biomarker in rat population
| Project/Area Number |
24380071
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyushu University |
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Principal Investigator |
SATO Masao 九州大学, (連合)農学研究科(研究院), 准教授 (90294909)
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| Co-Investigator(Kenkyū-buntansha) |
SHIROUTI Bungo 九州大学, 大学院農学研究院, 助教 (00548018)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
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| Keywords | 脂肪酸 / 酸化コレステロール / バイオマーカ / 連鎖解析 / 疫学 / 疾患対応型モデル動物 / ExHCラット / 肥満 / リン脂質脂肪酸組成 / 糖尿病 / ラットF2集団 |
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| Outline of Final Research Achievements |
In this study, EXHC rats mated with BN rats. In the generation 2, F2, serum dihomo-g-linoeinic acid and DHA levels linked to body weight gain. However, the dihomo-g-linoeinic acid levels did not relate to a gene mutation by linkage analysis. The DHA levels related to a mutation in a gene. Therefore, serum fatty said composition as a biomarker in a population may divide into two groups of life style-lelated and mutation related fatty acids.
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Report
(4 results)
Research Products
(12 results)
