| Budget Amount *help |
¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Outline of Final Research Achievements |
Salsolinol(SAL), a dopamine (DA)-derived compound, is a putative endogenous prolactin (PRL)-releasing factor in ruminants. The aim of the present study was to clarify the secretory mechanisms of PRL by SAL in ruminants. Daily oral administrations of melatonin (MEL) under a long photoperiod reduced the PRL-releasing response to SAL in goats. The treatments with augmentation of central DA using carbidopa and L-dopa blunted SAL-induced PRL release in goats, regardless of the photoperiod. The treatments with depletion of central DA using reserpine modulated SAL-induced PRL release in goats. The present study demonstrated that hypothalamic MEL and DA are involved in the secretory mechanisms of PRL by SAL in goats. These results provide further evidence that SAL is involved in the regulatory processes of PRL secretion in ruminants.
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