Development of aerobic alcohol oxidation systems based on nitroxyl radical-Cu catalysis
| Project/Area Number |
24390001
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 空気酸化 / アルコール酸化 / 酸化触媒 / 銅ニトロキシド / 不斉酸化 / 化学選択性 |
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| Outline of Final Research Achievements |
We have successfully developed the highly chemoslective aerobic alcohol oxidation using nitroxyl radical-copper catalysis that realize an efficient transformation of an unprotected amino-alcohol into the corresponding amino-carabonyl compound. We have identified the optimum combination of nitroxyl radical, copper salt, and solution concentration dependent on the type of substrate. Useful information of the catalyst structure-enantioselectivity relationship has been obtained, which will lead the development of an enantioselective aerobic oxidation system.
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Report
(4 results)
Research Products
(21 results)
