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Elucidation of the mechanism of bone metabolism controlled by Cdk6 transcription factory

Research Project

Project/Area Number 24390450
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionThe University of Tokyo

Principal Investigator

OGASAWARA Toru  東京大学, 医学部附属病院, 講師 (20359623)

Co-Investigator(Kenkyū-buntansha) CHIKUDA hirotaka  東京大学, 医学部附属病院, 准教授 (30345219)
OGATA Naoshi  帝京大学, 医学部, 教授 (10361495)
ABE Masanobu  東京大学, 医学部附属病院・保健・健康推進部, 講師 (10392333)
FUJIHARA Yuko  東京大学, 医学部附属病院, 助教 (50466744)
MORO Toru  東京大学, 医学部附属病院, 准教授 (20302698)
ABE Takahiro  東京大学, 医学部附属病院, 講師 (20383250)
INOKUCHI Takato  東京大学, 医学部附属病院, 助教 (80587775)
KAWAGUCHI Hiroshi  東京大学, 医学部附属病院, 届出診療医 (40282660)
Co-Investigator(Renkei-kenkyūsha) TAKATO Tsuyoshi  東京大学, 医学部附属病院, 教授 (90171454)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Keywords骨代謝 / 細胞周期 / クロマチン免疫沈降法 / 細胞分化 / 再生医学 / ノックアウトマウス
Outline of Final Research Achievements

This study aimed to clarify the mechanism(s) of bone metabolism controlled by Cdk6 transcription factory. DNA microarray analysis and ChIP-sequencing analysis revealed that Cdk6 regulate transcription of Type I collagen, Alkaline phosphatase, BMP receptors, Sox family, Myogenin and Semaphorins etc. In conclusion, the results of this study suggested that Cdk6 transcription factory regulate genes involving in bone metabolism and those functioning in other important cellular processes.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (9 results)

All 2015 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (2 results) Remarks (4 results)

  • [Journal Article] Runx1 and Runx3 Are Downstream Effectors of Nanog in Promoting Osteogenic Differentiation of the Mouse Mesenchymal Cell Line C3H10T1/22015

    • Author(s)
      Saito T, Ohba S, Yano F, Seto I, Yonehara Y, Takato T, Ogasawara T
    • Journal Title

      Cell Reprogram

      Volume: 17 Issue: 3 Pages: 227-234

    • DOI

      10.1089/cell.2014.0059

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell cycle control factors and skeletal development2013

    • Author(s)
      Toru Ogasawara
    • Journal Title

      The Japanese Dental Science Review

      Volume: 49 Issue: 2 Pages: 79-87

    • DOI

      10.1016/j.jdsr.2013.03.001

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvements of runt-related transcription factor 2 with cell-cycle machinery in osteoblasts and skeletal development: a review of the literature2013

    • Author(s)
      Toru Ogasawara
    • Journal Title

      Hard Tissue

      Volume: 2 Pages: 29-29

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Nanogの間葉系細胞骨分化能促進効果におけるRunxファミリー(Runx1/2/3)の関与2014

    • Author(s)
      小笠原徹
    • Organizer
      第68回NPO法人日本口腔科学会学術大会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2014-05-08 – 2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Runx1 and Runx3 are downstream effectors of Nanog in the promoted osteogenic differentiation of mesenchymal cells.2013

    • Author(s)
      Toru Ogasawara et al.
    • Organizer
      2013 annual meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Baltimore, Maryland, USA, Baltimore Convention Cente
    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京大学医学部附属病院 顎口腔外科・歯科矯正歯科ホームページ

    • URL

      http://plaza.umin.ac.jp/~oralsurg/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京大学医学部附属病院顎口腔外科・歯科矯正歯科ホームページ

    • URL

      http://plaza.umin.ac.jp/~oralsurg/archive.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京大学医学部附属病院 顎口腔外科・歯科矯正歯科ホームページ

    • URL

      http://plaza.umin.ac.jp/~oralsurg/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/~oralsurg/

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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