Elucidation of the mechanism of bone metabolism controlled by Cdk6 transcription factory

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390450
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: The University of Tokyo
• Principal Investigator: OGASAWARA Toru 東京大学, 医学部附属病院, 講師 (20359623)
• Co-Investigator(Kenkyū-buntansha): CHIKUDA hirotaka 東京大学, 医学部附属病院, 准教授 (30345219) ; OGATA Naoshi 帝京大学, 医学部, 教授 (10361495) ; ABE Masanobu 東京大学, 医学部附属病院・保健・健康推進部, 講師 (10392333) ; FUJIHARA Yuko 東京大学, 医学部附属病院, 助教 (50466744) ; MORO Toru 東京大学, 医学部附属病院, 准教授 (20302698) ; ABE Takahiro 東京大学, 医学部附属病院, 講師 (20383250) ; INOKUCHI Takato 東京大学, 医学部附属病院, 助教 (80587775) ; KAWAGUCHI Hiroshi 東京大学, 医学部附属病院, 届出診療医 (40282660)
• Co-Investigator(Renkei-kenkyūsha): TAKATO Tsuyoshi 東京大学, 医学部附属病院, 教授 (90171454)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 骨代謝 / 細胞周期 / クロマチン免疫沈降法 / 細胞分化 / 再生医学 / ノックアウトマウス

Outline of Final Research Achievements

This study aimed to clarify the mechanism(s) of bone metabolism controlled by Cdk6 transcription factory. DNA microarray analysis and ChIP-sequencing analysis revealed that Cdk6 regulate transcription of Type I collagen, Alkaline phosphatase, BMP receptors, Sox family, Myogenin and Semaphorins etc. In conclusion, the results of this study suggested that Cdk6 transcription factory regulate genes involving in bone metabolism and those functioning in other important cellular processes.

Free Research Field

骨代謝学