Molecular mechanisms underlying the epilepsy using a mutant model with seizures
Project/Area Number |
24500399
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neuroscience in general
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Research Institution | National Center of Neurology and Psychiatry |
Principal Investigator |
TAYA Shinichiro 独立行政法人国立精神・神経医療研究センター, 神経研究所 病態生化学研究部, 室長 (60362232)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | てんかん / 発達障害 / 神経科学 / 精神遅滞 |
Outline of Final Research Achievements |
The Ihara epileptic rat (IER) is a mutant model with limbic-like seizures whose pathology and causative gene remain elusive. We identified the responsible gene for IER, Epi-IER, which is expressed in neurons of various brain regions. A single base mutation in Epi-IER caused abnormal splicing leading to lack of Epi-IER protein in IER. Our gain- and loss-of function experiments in vivo and in vitro showed that Epi-IER is involved in neurite extension and branching. These findings help to understand the pathology of epilepsy caused by a malformed neural network and how Epi-IER functions to prevent such disorder.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis.2014
Author(s)
Hori K, Nagai T, Shan W, Sakamoto A, Taya S, Hashimoto R, Hayashi T, Abe M, Yamazaki M, Nakao K, Nishioka T, Sakimura K, Yamada K, Kaibuchi K, Hoshino M.
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Journal Title
Cell Report
Volume: 9
Pages: 2166-2179
DOI
Related Report
Peer Reviewed
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[Journal Article] Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum.2014
Author(s)
Seto Y, Nakatani T, Masuyama N, Taya S, Kumai M, Minaki Y, Hamaguchi A, Inoue Y, Inoue T, Miyashita S, Fujiyama T, Yamada M, Chapman H, Campbell K, Magnuson M, Wright C, Kawaguchi Y, Ikenaka K, Takebayashi H, Ishiwata S, Ono Y, Hoshino M.
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Journal Title
Nature Communications
Volume: 5
Pages: 3337
DOI
Related Report
Peer Reviewed
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[Journal Article] Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum.2014
Author(s)
2. Seto Y, Nakatani T, Masuyama N, Taya S, Kumai M, Minaki Y, Hamaguchi A, Inoue Y, Inoue T, Miyashita S, Fujiyama T, Yamada M, Chapman H, Campbell K, Magnuson M, Wright C, Kawaguchi Y, Ikenaka K, Takebayashi H, Ishiwata S, Ono Y, Hoshino M.
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Journal Title
Nature Communications
Volume: 5
Pages: 3337
DOI
Related Report
Peer Reviewed
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