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Super engineering plastics-made artificial cancellous bone for an artificial articular cartilage

Research Project

Project/Area Number 24500533
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKinki University

Principal Investigator

HAYAMI Takashi  近畿大学, 生物理工学部, 教授 (20173057)

Co-Investigator(Kenkyū-buntansha) KUSUNOKI Masanobu  近畿大学, 生物理工学部, 教授 (20282238)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords人工関節軟骨 / 人工骨 / バイオマテリアル
Outline of Final Research Achievements

We have investigated the use of polyvinyl alcohol hydrogels (PVA-H) for hemiarthroplasty. In this project, we studied materials and structures of the artificial bone and cartilage constituting artificial articular cartilages. For this aim, the technique which supplies biocompatibility and suitable cancellous structure to the engineering plastic (EP) as the artificial cancellous bone was studied. And also, tribological properties of PVA-H as the artificial cartilage versus natural articular cartilage was studied.
Deposition of titanium thin film to the EP surface imparted good osteoconduction and the proliferation and differentiation ability of osteoblasts to the EP bone. The wear resistance of the PVA-H mixed in only water (PVA-H/Water) which is developed in this project was compared with that of the PVA-H mixed in a conventional mixture of water and dimethyl sulfoxide (PVA/DMSO). The results indicated no significant difference in the wear resistance between PVA-H/DMSO and PVA-H/Water.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2014 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (13 results)

  • [Journal Article] In vitro response and adhesive strength of titanium and apatite bilayer-films on polyetheretherketone substrate2014

    • Author(s)
      Takashi Hayami
    • Journal Title

      Key Engineering Materials

      Volume: 583 Pages: 51-55

    • DOI

      10.4028/www.scientific.net/kem.583.51

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Frictional Properties of Polyvinyl Alcohol Hydrogel Mixed with Water as an Artificial Articular Cartilage2014

    • Author(s)
      Koji Morimoto
    • Journal Title

      IFMBE Proceedings

      Volume: 43 Pages: 714-717

    • DOI

      10.1007/978-3-319-02913-9_182

    • ISBN
      9783319029122, 9783319029139
    • Related Report
      2013 Research-status Report
  • [Presentation] Friction of polyvinyl alcohol hydrogel as Articular Cartilage2014

    • Author(s)
      Morimoto.K, Kimura.Y, Hirokawa.N, Shibue.T ,Hayami.T
    • Organizer
      第24回日本MRS学会年次大会
    • Place of Presentation
      横浜開港記念会館(横浜市中区)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 人工軟骨として用いるPVAハイドロゲルの力学的特性と潤滑特性2014

    • Author(s)
      森本浩嗣、木村佳弘、廣川敬康、渋江唯司、速水尚
    • Organizer
      日本ゴム協会第26回エラストマー討論会
    • Place of Presentation
      愛知工業大学(豊田市八草町)
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Surface modification of poly(vinyl alcohol)hydrogel by graft polymerization of betaine polymer2014

    • Author(s)
      Hirano.Y, Hayami.T, Yoshikawa.S, Sirasaki.R, Morimoto.K, Matsumura.K
    • Organizer
      The 10th SPSJ International Polymer Conference
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2014-12-02 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 人工関節軟骨用ポリビニルアルコールハイドロゲルへのベタインポリマーのグラフト重合2014

    • Author(s)
      平野由起、森本浩嗣、吉川祥、白崎諒一、速水尚、松村和明
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2014-11-17 – 2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Reciprocating Sliding Friction of Polyvinyl Alcohol Hydrogels as Articular Cartilage Substitutes2014

    • Author(s)
      Hayami.T, Morimoto.K, Kimura.Y, Hirokawa.N, Shibue.T
    • Organizer
      The 26th European Conference on Biomaterials
    • Place of Presentation
      Liverpool(United Kingdom)
    • Year and Date
      2014-08-31 – 2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 人工関節軟骨・PVAハイドロゲルの摩擦特性―水溶媒とジメチルスルホキシド溶媒の違いについて―

    • Author(s)
      森本浩嗣
    • Organizer
      日本設計工学会春季研究発表講演会
    • Place of Presentation
      国士舘大学(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] 人工骨への応用を目的としたスーパーエンジニアリングプラスチックに対する生体親和性の付与

    • Author(s)
      岡田和真
    • Organizer
      日本生体医工学会 生体医工学シンポジウム2013
    • Place of Presentation
      九州大学(福岡市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 水溶媒だけで作製したPVAハイドロゲルの硬さと潤滑特性

    • Author(s)
      森本浩嗣
    • Organizer
      第40回日本臨床バイオメカニクス学会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Frictional properties of polyvinyl alcohol hydrogel mixed with water as an artificial articular cartilage

    • Author(s)
      Koji Morimoto
    • Organizer
      The 15th International Conference on Biomedical Engineering
    • Place of Presentation
      Singapore国立大学(シンガポール)
    • Related Report
      2013 Research-status Report
  • [Presentation] In vitro response and adhesive strength of titanium and hydroxyapatite bilayer coating on polyetheretherketone (PEEK) substrate

    • Author(s)
      T. Hayami
    • Organizer
      International Conference “Biomaterials, Tissue Engineering & Medical Devices” BiomMedD’2012
    • Place of Presentation
      Ovidius大学(コンスタンタ、ルーマニア)
    • Related Report
      2012 Research-status Report
  • [Presentation] Crystallization Control of Hydroxyapatite Sheet

    • Author(s)
      M.Kusunoki
    • Organizer
      International Conference “Biomaterials, Tissue Engineering & Medical Devices” BiomMedD’2012
    • Place of Presentation
      Ovidius大学(コンスタンタ、ルーマニア)
    • Related Report
      2012 Research-status Report
  • [Presentation] 人工骨への応用を目的としたチタンスパッタ膜の評価

    • Author(s)
      岡田和真
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台国際センター(宮城県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 医療応用を目的としたスーパーエンジニアリングプラスチックに対するチタンスパッタ膜の評価

    • Author(s)
      岡田和真
    • Organizer
      平成24年電気関係学会関西連合大会
    • Place of Presentation
      関西大学(大阪府)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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