Super engineering plastics-made artificial cancellous bone for an artificial articular cartilage
| Project/Area Number |
24500533
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUSUNOKI Masanobu 近畿大学, 生物理工学部, 教授 (20282238)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 人工関節軟骨 / 人工骨 / バイオマテリアル |
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| Outline of Final Research Achievements |
We have investigated the use of polyvinyl alcohol hydrogels (PVA-H) for hemiarthroplasty. In this project, we studied materials and structures of the artificial bone and cartilage constituting artificial articular cartilages. For this aim, the technique which supplies biocompatibility and suitable cancellous structure to the engineering plastic (EP) as the artificial cancellous bone was studied. And also, tribological properties of PVA-H as the artificial cartilage versus natural articular cartilage was studied.
Deposition of titanium thin film to the EP surface imparted good osteoconduction and the proliferation and differentiation ability of osteoblasts to the EP bone. The wear resistance of the PVA-H mixed in only water (PVA-H/Water) which is developed in this project was compared with that of the PVA-H mixed in a conventional mixture of water and dimethyl sulfoxide (PVA/DMSO). The results indicated no significant difference in the wear resistance between PVA-H/DMSO and PVA-H/Water.
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Report
(4 results)
Research Products
(15 results)
