• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Selectivity in the intestinal absorption of carotenoids and their bioavailability

Research Project

Project/Area Number 24500962
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionNational Agriculture and Food Research Organization

Principal Investigator

KOTAKE Eiichi  独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所食品素材科学研究領域, 主任研究員 (20547236)

Co-Investigator(Kenkyū-buntansha) NAGAO Akihiko  独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所食品素材科学研究領域, 上席研究員 (40353958)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsカロテノイド / 腸管吸収 / グリセロ糖脂質 / 生体利用性
Outline of Final Research Achievements

Although no less than 40 carotenoids are ingested under usual dietary habits, several carotenoids and their metabolites have been found in human tissues. We hypothesized that there are selectivity in the intestinal absorption, and then studied the three points: the absorption receptor, excretion transporters, and absorption control by food components. Absorption mediated by receptor was 20-30% of total absorption. Both facilitated diffusion and simple diffusion would mediate the intestinal absorption, but the contribution of simple diffusion is higher than that of facilitated diffusion. The excretion transporters may also participate in the selectivity of intestinal absorption. However, we have not found the participation. On the other hand, we found that some dietary compound lipids affected the absorption of carotenoids. These lipids enhanced the absorption by decreasing the intercellular barrier integrity by cell-to-cell/cell-matrix adhesion.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2015 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 2 results)

  • [Journal Article] 脂溶性機能成分の可溶化と腸管吸収―カロテノイドの吸収促進―2015

    • Author(s)
      小竹英一
    • Journal Title

      New Food Industry

      Volume: 57

    • NAID

      40020545529

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Glyceroglycolipids Affect Uptake of Carotenoids Solubilized in Mixed Micelles by Human Intestinal Caco-2 Cells2015

    • Author(s)
      Eiichi Kotake-Nara, Lina Yonekura, Akihiko Nagao
    • Journal Title

      Lipids

      Volume: 50

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] カロテノイドの腸管吸収、代謝と機能2015

    • Author(s)
      小竹英一
    • Organizer
      日本農芸化学会東北支部シンポジウム
    • Place of Presentation
      岩手大学(岩手県盛岡市)
    • Year and Date
      2015-07-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ヒト腸管上皮細胞株Caco-2によるカロテノイドの取込みに対するグリセロ糖脂質の影響2013

    • Author(s)
      小竹 英一、Yonekura Lina、長尾 昭彦
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2012 Research-status Report
  • [Presentation] カロテノイドの消化吸収と代謝

    • Author(s)
      小竹 英一
    • Organizer
      第21回植物油栄養懇話会
    • Place of Presentation
      如水会館(東京)
    • Related Report
      2013 Research-status Report
    • Invited

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi