Molecular analysis of streptococcus derived protein factors for application to drug discovery
| Project/Area Number |
24590221
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
OHKURA Kazuto 鈴鹿医療科学大学, 薬学部, 教授 (00242850)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAMUNE Hideaki 徳島大学, 大学院ソシオテクノサイエンス研究部ライフシステム部門 (40189163)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 細菌感染症 / タンパク質毒素 / 感染症 / ヒト特異的 |
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| Outline of Final Research Achievements |
Molecular features of Streptococci derived cytolysins were examined. Especially, the structural function of cholesterol dependent cytolysin (CDC), human specific intermedilysin (ILY), Kawasaki disease related factor (Sm-hPAF), and miscarriage related vaginolysin (VLY), were analyzed.
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Report
(4 results)
Research Products
(29 results)
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[Presentation] Streptolysin S homologues of peptide hemolysin: Novel beta-hemolytic factors distributed among beta-hemolytic anginosus group Streptococci2014
Author(s)
Atsushi Tabata, Kota Nakano, Yuji Sato, Kentaro Maya, Hiromi Ohtani, Yukimasa Ohkubo, Kazuto Ohkura, Ken Kikuchi, Robert Whiley, Toshifumi Tomoyasu, Hideaki Nagamune
Organizer
XIX Lancefield International Symposium on Streptococci and Streptococcal Diseases
Place of Presentation
アルゼンチン
Year and Date
2014-11-09 – 2014-11-12
Related Report
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