Molecular mechanism of the non-uniform response and reversible differentiation of stem cells
| Project/Area Number |
24590232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Hiroshima University (2013-2014)
The University of Tokyo (2012) |
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Principal Investigator |
TAKAHASHI SHUJI 広島大学, 理学(系)研究科(研究院), 特任准教授 (90447318)
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| Co-Investigator(Kenkyū-buntansha) |
ARIIZUMI Takashi 玉川大学, 農学部, 教授 (30286166)
TANAKA Toshiaki 東京工業大学, 生命理工学研究科, 助教 (40263446)
NINOMIYA Hiromasa 東京大学, 総合文化研究科, 学術研究員 (40514237)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アフリカツメガエル / ネッタイツメガエル / ヒトiPS細胞 / 細胞分化 / 発生生物学 / 幹細胞 |
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| Outline of Final Research Achievements |
In this study, we screened switch factors for two different endoderm in Xenopus. Using information from DNA array and study of the other model animals, a lot of gene are cloned and tested by overexpression.
However, the factors did not identified. We are trying to functional screening.
We developed a new induction method from human iPS cell to embryonic endoderm. Using this methods, We are trying to induce pancreatic endoderm.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Ubiquitin-interacting motifs confer full catalytic activity, but not ubiquitin chain substrate specificity, to deubiquitinating enzyme USP372014
Author(s)
Tanno, H., Shigematsu, T., Nishikawa, S., Hayakawa, A., Denda, K., Tanaka, T., and Komada, M.
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Journal Title
J. Biol. Chem.
Volume: 289
Issue: 4
Pages: 2415-2423
DOI
Related Report
Peer Reviewed
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[Journal Article] ERK-dependent downregulation of Skp2 reduces Myc activity with HGF, leading to inhibition of cell proliferation through a decrease in Id1 expression2013
Author(s)
Li, X., Bian, Y., Takizawa, Y., Hashimoto, T., Ikoma, T., Tanaka, J., Kitamura, N., Inagaki, Y., Komada, M., and Tanaka, T.
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Journal Title
Mol. Cancer Res.
Volume: 11
Issue: 11
Pages: 1437-1447
DOI
Related Report
Peer Reviewed
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[Journal Article] Critical role of farnesoid X receptor (FXR) for hepatocellular carcinoma cell Proliferation.2012
Author(s)
T.Fujino, A.Takeuchi, A.Maruko-Ohtake, Y.Ohtake, J.Satoh,T.Kobayashi, T.Tanaka, H.Ito, R.Sakamaki, R.Kashimura, K. Ando, T.Nishimaki-Mogami, Y.Ohkubo, R.Sato, K.Kikugawa, M.Hayakawa.
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Journal Title
Journal of Biochemistry
Volume: 152
Issue: 6
Pages: 577-586
DOI
Related Report
Peer Reviewed
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[Presentation] Genomics Study of the Spemann-Mangold Organizer: Occupancy of Tissue-Specific cis-Regulatory Modules by Otx2 and TLE/Groucho for Embryonic Head Specification.2014
Author(s)
Yuuri Yasuoka, Yutaka Suzuki, Shuji Takahashi, Haruka Someya, Norihiro Sudou, Yoshikazu Haramoto, Ken Cho, Makoto Asashima, Sumio Sugano, Masanori Taira
Organizer
15th International Xenopus Conference
Place of Presentation
Asilomar (California, USA)
Year and Date
2014-08-24 – 2014-08-30
Related Report
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[Presentation] Analysis of the Xenopus laevis J-strain genome by BAC end sequencing, FISH, and RNA-sequence2012
Author(s)
Takahashi S, Toyoda A, Kuroki Y, Uno Y, Izutsu Y, Suzuki A, Michiue T, Ogino H, Ochi H, Tanaka T, Fukui A, Ito Y, Ueno N, Asashima M, Matsuda Y, Taira M, Fujiyama A.
Organizer
14th International Xenopus Conference
Place of Presentation
Club Belambra（Gien Peninsula, France）
Related Report
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[Presentation] Massively parallel regulation of head and non-head genes by Otx2, Lim1 and Gsc underlies the evolution of the head organizer in the chordate.2012
Author(s)
Yuuri Yasuoka, Yutaka Suzuki, Shuji Takahashi, Norihiro Sudou, Yoshikazu Haramoto, Yukiko Tandou, Kaoru Kubokawa, Ken W. Cho, Makoto Asashima, Sumio Sugano, Masanori Taira
Organizer
第45回日本発生生物学会大会
Place of Presentation
神戸国際会議場（神戸）
Related Report
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[Presentation] What we can do with over 300 billion bases of RNA-seq data: The case of Xenopus laevis genome project.
Author(s)
Taejoon Kwon, Shuji Takahashi, Toshiaki Tanaka, Hideki Noguchi, Atsushi Toyoda, Asao Fujiyama, Yutaka Suzuki, Naoto Ueno, Masanori Taira, John B. Wallingford, Edward M. Marcotte.
Organizer
International Symposium on Genome Science
Place of Presentation
The University of Tokyo, Ito International Research Center（東京）
Related Report
Invited
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[Presentation] Analysis of the Xenopus laevis J-strain genome by BAC end sequencing, FISH, and RNA-sequence
Author(s)
Shuji Takahashi, Atsushi Toyoda, Yoko Kuroki, Yoshinobu Uno, Hideki Noguchi, Yumi Izutsu, Atsushi Suzuki, Tatsuo Michiue, Hajime Ogino, Hirofumi Ochi, Toshiaki Tanaka et al.
Organizer
International Symposium on Genome Science
Place of Presentation
The University of Tokyo, Ito International Research Center（東京）
Related Report
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