| Project/Area Number |
24590232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Hiroshima University (2013-2014)
The University of Tokyo (2012) |
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Principal Investigator |
TAKAHASHI SHUJI 広島大学, 理学(系)研究科(研究院), 特任准教授 (90447318)
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| Co-Investigator(Kenkyū-buntansha) |
ARIIZUMI Takashi 玉川大学, 農学部, 教授 (30286166)
TANAKA Toshiaki 東京工業大学, 生命理工学研究科, 助教 (40263446)
NINOMIYA Hiromasa 東京大学, 総合文化研究科, 学術研究員 (40514237)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アフリカツメガエル / ネッタイツメガエル / ヒトiPS細胞 / 細胞分化 / 発生生物学 / 幹細胞 |
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| Outline of Final Research Achievements |
In this study, we screened switch factors for two different endoderm in Xenopus. Using information from DNA array and study of the other model animals, a lot of gene are cloned and tested by overexpression.
However, the factors did not identified. We are trying to functional screening.
We developed a new induction method from human iPS cell to embryonic endoderm. Using this methods, We are trying to induce pancreatic endoderm.
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