Notch signal controls the survival of memory CD4+ T cells
Project/Area Number |
24590585
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Immunology
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Research Institution | Gifu University |
Principal Investigator |
MAEKAWA Yoichi 岐阜大学, 医学(系)研究科(研究院), 教授 (10294670)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 免疫記憶 / メモリーCD4陽性T細胞 / Notchシグナル / グルコース代謝 / Akt / メモリーCD4 T細胞 / Notch / メモリーT細胞 / PI3K/AKT / Rbpj / Notch1 / Notch2 / メモリーCD4T細胞 |
Outline of Final Research Achievements |
CD4+ T cells differentiate into memory T cells that protect the host from subsequent infection. The underlying pathways controlling the maintenance of memory CD4+ T cells remain undefined. Memory CD4+ T cell survival is impaired in the absence of the Notch signaling protein known as recombination signal binding protein for immunoglobulin k J region (Rbpj). Rbpj-deficient CD4+ memory T cells exhibit reduced glucose uptake due to impaired Akt phosphorylation, resulting in low Glut1 expression. Together, these data define a central role for Notch signaling in maintaining memory CD4+ T cells through the regulation of glucose uptake.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Dll4-Fc, an inhibitor of Dll4-Notch signaling, suppresses liver metastasis of small cell lung cancer cells through the downregulation of the NF-kappa-B activity.2012
Author(s)
Kuramoto T, Goto H, Mitsuhashi A, Tabata S, Ogawa H, Uehara H, Sijo A, Kakiuchi S, Maekawa, Yasutomo K, Hanibuchi M, Akiyama SI, Sone S, Nishioka Y
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Journal Title
Mol Cancer Ther
Volume: 11
Issue: 12
Pages: 2578-2587
DOI
Related Report
Peer Reviewed
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