| Project/Area Number |
24590921
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
SATO Yasushi 札幌医科大学, 医学部, 講師 (80343383)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKIMOTO Risyu 札幌医科大学, 医学部, 准教授 (10336399)
KATO Jyunji 札幌医科大学, 医学部, 教授 (20244345)
HIRAKAWA Masahiro 札幌医科大学, 医学部, 助教 (50561023)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 胃癌 / 転移 / STn抗原 |
|---|
| Outline of Final Research Achievements |
ST6GalNAc I is a sialyltransferase controlling the expression of sialyl-Tn antigen (STn), which is overexpressed in several epithelial cancers, including gastric cancer, and is highly correlated with cancer metastasis. However, the functional contribution of ST6GalNAc I to development or progression of gastric cancer remains unclear. We investigated the effects of suppression of ST6GalNAc I on gastric cancer in vitro and in vivo. ST6GalNAc I siRNA inhibited gastric cancer cell growth, migration, and invasion in vitro. Furthermore, intraperitoneal administration of ST6GalNAc I siRNA- liposome significantly inhibited peritoneal dissemination and prolonged the survival of xenograft model mice with peritoneal dissemination of gastric cancer. Therefore, ST6GalNAc I may be a potential target for treatment of metastasizing gastric cancer.
|
