A novel approach in the treatment of metastatic gastric cancer: targeting the STn synthase

• Project/Area Number: 24590921
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Sapporo Medical University
• Principal Investigator: SATO Yasushi 札幌医科大学, 医学部, 講師 (80343383)
• Co-Investigator(Kenkyū-buntansha): TAKIMOTO Risyu 札幌医科大学, 医学部, 准教授 (10336399) ; KATO Jyunji 札幌医科大学, 医学部, 教授 (20244345) ; HIRAKAWA Masahiro 札幌医科大学, 医学部, 助教 (50561023)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 胃癌 / 転移 / STn抗原

Outline of Final Research Achievements

ST6GalNAc I is a sialyltransferase controlling the expression of sialyl-Tn antigen (STn), which is overexpressed in several epithelial cancers, including gastric cancer, and is highly correlated with cancer metastasis. However, the functional contribution of ST6GalNAc I to development or progression of gastric cancer remains unclear. We investigated the effects of suppression of ST6GalNAc I on gastric cancer in vitro and in vivo. ST6GalNAc I siRNA inhibited gastric cancer cell growth, migration, and invasion in vitro. Furthermore, intraperitoneal administration of ST6GalNAc I siRNA- liposome significantly inhibited peritoneal dissemination and prolonged the survival of xenograft model mice with peritoneal dissemination of gastric cancer. Therefore, ST6GalNAc I may be a potential target for treatment of metastasizing gastric cancer.

Research Products

• [Journal Article] RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells (2014)
  • Author(s): Tamura F, Sato Y, Hirakawa M, Yoshida M, Ono M, Osuga T, Okagawa Y, Uemura N, Arihara Y, Murase K, Kawano Y, Iyama S, Takada K, Hayashi T, Sato T, Miyanishi K, Kobune M, Takimoto R, Kato J.
  • Journal Title: Gastric Cancer Volume: 23 Issue: 1 Pages: 85-97
  • DOI: 10.1007/s10120-014-0454-z
  • NAID: 40020700032
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach. (2012)
  • Author(s): Yoshida M, Takimoto R, Murase K, Sato Y, Hirakawa M, Tamura F, Sato T, Iyama S, Osuga T, Miyanishi K, Takada K, Hayashi T, Kobune M, Kato J.
  • Journal Title: PLoS One Volume: 7(7) Issue: 7 Pages: e39545-e39545
  • DOI: 10.1371/journal.pone.0039545
  • Peer Reviewed