study on pancreatic cancer using adiponectin: risk factor analysis and development of new treatment
Project/Area Number |
24591011
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Osaka University |
Principal Investigator |
KENJI WATABE 大阪大学, 医学部附属病院, 准教授 (50379244)
|
Co-Investigator(Kenkyū-buntansha) |
TSUJII Masahiko 大阪大学, 医学系研究科, 准教授 (40303937)
KISO Shinnichi 大阪大学, 医学系研究科, 特任准教授 (40335352)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 膵臓癌 / 肥満 / 内臓脂肪 / アディポネクチン / アポトーシス / 膵星細胞 / 膵癌 |
Outline of Final Research Achievements |
In Japan, more than 30,000 people die from pancreatic cancer. Obesity is a risk factor for the development and growth of pancreatic cancer. The mechanisms underlying the association between obesity and pancreatic cancer have been investigated through hormonal, inflammatory and immunological changes in obesity. Adiponectin is an adipose tissue-derived secretory hormone. In this study, we investigated the role of adiponectin in the growth of pancreatic cancer. We examined the effect of adiponectin on the growth of Pan02 murine pancreatic cancer cells using recombinant adiponectin and adiponectin knockout mice. The in vitro treatment of Pan02 cells with adiponectin inhibited cellular proliferation that was accompanied by increased apoptosis. Transplantation of Pan02 cells into the pancreas of knockout mice resulted in a larger tumor volume with fewer apoptotic cells compared with wild type mice. The results indicate that adiponectin directly suppresses the proliferation of Pan02 cells.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] 5FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53‑mutated colon cancer cells.2015
Author(s)
Akasaka T, Tsujii M, Kondo J, Hayashi Y, Ying J, Lu Y, Kato M, Yamada T, Yamamoto S, Inoue T, Tsujii Y, Maekawa A, Fujinaga T, Shiraishi E, Hiyama S, Inoue T, Shinzaki S, Watabe K, Nishida T, Iijima H, Takehara T.
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Journal Title
Int J Oncol.
Volume: 46
Issue: 1
Pages: 63-70
DOI
Related Report
Peer Reviewed
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[Journal Article] The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to target colon cancer stem-like cells.2015
Author(s)
Ying J, Tsujii M, Kondo J, Hayashi Y, Kato M, Akasaka T, Inoue T, Shiraishi E, Inoue T, Hiyama S, Tsujii Y, Maekawa A, Kawai S, Fujinaga T, Araki M, Shinzaki S, Watabe K, Nishida T, Iijima H, Takehara T.
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Journal Title
Int J Oncol.
Volume: 46
Issue: 4
Pages: 1151-1159
DOI
Related Report
Peer Reviewed
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[Journal Article] Gastric Contraction Imaging System Using a 3-D Endoscope2014
Author(s)
Kayo Yoshimoto, Kenji Yamada, Kenji Watabe, Maki Takeda, Takahiro Nishimura, Michiko Kido, Toshiaki Nagakura, Hideya Takahashi, Tsutomu Nishida, Hideki Iijima, Masahiko Tsujii, Tetsuo Takehara, Yuko Ohno
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Journal Title
IEEE Journal of Translational Engineering in Health and Medicine
Volume: vol.2, no.1
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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