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Analysis of growth and differentiation network system for immune cells of adipocyte by hormone during childhood

Research Project

Project/Area Number 24591515
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionOita University (2014-2016)
Kyushu University (2012-2013)

Principal Investigator

Ihara Kenji  大分大学, 医学部, 教授 (80294932)

Co-Investigator(Kenkyū-buntansha) 石井 加奈子  九州大学, 大学病院, 学術研究員 (90400332)
Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords成長ホルモン / 脂肪細胞 / 免疫細胞 / メタボローム / マクロファージ / ネットワーク / アディポネクチン / 肥満 / 脂肪
Outline of Final Research Achievements

We studied growth hormone (GH) for the differentiation and proliferation of adipocytes via activation of monocytes. Pretreatment with GH, RAW 264 cells decreased the degree of reduction of adiponectin production when co-cultured with adipocytes. It was presumed that some humoral factors produced by macrophage with GH stimulation had influenced on adiponectin expression from adipocytes. Next, metabolome analysis of the produced factors from RAW 264 cell with or without GH treatment suggested the significant changes in amino acid metabolites (such as glutamine and glutamic acid) in the TCA cycle.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (43 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (23 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 23 results,  Open Access: 6 results) Presentation (15 results) (of which Invited: 7 results) Book (5 results)

  • [Journal Article] Hyperinsulinemic hypoglycemia in Beckwith-Wiedemann, Sotos and Kabuki syndromes: A nationwide survey in Japan2017

    • Author(s)
      Toda N, Ihara K, Kojima-Ishii K, Ochiai M, Ohkubo K, Kawamoto Y Kohno Y, Kumasaka S, Kawase A, Ueno Y, Futatani T, Miyazawa T, Nagaoki Y, Nakata S, Misaki M, Arai H, Kawai M, Sato M, Yada Y, Takahashi N., Komatsu A, Maki K, Watabe S, Sumida Y, Kuwashima M, Mizumoto H, Sato K, Hara T
    • Journal Title

      Am J Med Genet

      Volume: 173 Issue: 2 Pages: 360-367

    • DOI

      10.1002/ajmg.a.38011

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FUT2 non-secretor status is associated with Type 1 diabetes susceptibility in Japanese children2017

    • Author(s)
      Ihara K, et al.
    • Journal Title

      Diabet Med

      Volume: 34 Issue: 4 Pages: 586

    • DOI

      10.1111/dme.13288

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A severe pulmonary complication in a patient with COL4A1-related disorder2017

    • Author(s)
      Abe Y, Matsuduka A, Okanari K, Miyahara H, Kato M, Miyatake S, Saitsu H, Matsumoto N, Tomoki M, Ihara K
    • Journal Title

      Eur J Med Genet

      Volume: 60 Issue: 3 Pages: 169-171

    • DOI

      10.1016/j.ejmg.2016.12.008

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 72016

    • Author(s)
      Narumi S*, et al., Matsumoto N, et al.
    • Journal Title

      Nat Genet

      Volume: 48 Issue: 7 Pages: 792-797

    • DOI

      10.1038/ng.3569

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Blood Reference Intervals for Preterm Low-Birth-Weight Infants: A Multicenter Cohort Study in Japan2016

    • Author(s)
      Ochiai M, Matsushita Y, Inoue H, Kusuda T, Kang D, Ichihara K, Nakashima N, Ihara K, Ohga S, Hara T
    • Journal Title

      PLoS One

      Volume: 11 Issue: 8 Pages: e0161439-e0161439

    • DOI

      10.1371/journal.pone.0161439

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of an Innate Immune Receptor, Nod1, Accelerates Atherogenesis in Apoe-/- Mice.2015

    • Author(s)
      Kanno S, Nishio H, Tanaka T, Motomura Y, Murata K, Ihara K, Onimaru M, Yamasaki S, Kono H, Sueishi K, Hara T
    • Journal Title

      J Immunol

      Volume: 194 Pages: 773-780

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] TYK2 Promoter Variant and Diabetes Mellitus in the Japanese.2015

    • Author(s)
      Nagafuchi S, Kamada-Hibio Y, Hirakawa K, Tsutsu N, Minami M, Okada A, Kai K, Teshima M, Moroishi A, Murakami Y, Umeno Y, Yokogawa Y, Kogawa K, Izumi K, Anzai K, Iwakiri R, Hamaguchi K, Sasaki N, Nohara S, Yoshida E, Harada M, Akashi K, Yanase T, Ono J, Okeda T, Fujimoto R, Ihara K, et al.
    • Journal Title

      EbioMedicine

      Volume: 2 Issue: 7 Pages: 744-749

    • DOI

      10.1016/j.ebiom.2015.05.004

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Moyamoya disease susceptibility gene RNF213 links inflammatory and angiogenic signals in endothelial cells.2015

    • Author(s)
      Ohkubo K, Sakai Y, Inoue H, Akamine S, Ishizaki Y, Matsushita Y, Sanefuji M, Torisu H, Ihara K, Sardiello M, Hara T
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 13191-13191

    • DOI

      10.1038/srep13191

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] The first nationwide survey and genetic analyses of Bardet-Biedl syndrome in Japan2015

    • Author(s)
      Hirano M, Satake W, Ihara K, Tsug I, Kondo S, Saida K, Betsui H, Okubo K, Sakamoto H, Ueno S, Ikuno Y, Ishihara R, Iwahashi H, Ohishi M, Mano T, Yamashita T, Suzuki Y, Nakamura Y, Kusunoki S, Toda T
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 9 Pages: e0136317-e0136317

    • DOI

      10.1371/journal.pone.0136317

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Survival and neurodevelopmental outcome of preterm infants born at 22-24 weeks of gestational age.2014

    • Author(s)
      Ochiai M, Kinjo T, Takahata Y, Iwayama M, Abe T, Ihara K, Ohga S, Fukushima K, Kato K, Taguchi T, Hara T
    • Journal Title

      Neonatology

      Volume: 10 Issue: 2 Pages: 79-84

    • DOI

      10.1159/000355818

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endocrine and metabolic abnormalities in a girl with childhood Werner syndrome: case report.2014

    • Author(s)
      Toda N, Ihara K, Takemoto M, Yokote K, Hara T.
    • Journal Title

      J Am Geriatr Soc

      Volume: 62 Issue: 7 Pages: 1404-1405

    • DOI

      10.1111/jgs.12897

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thyroid Follicular Carcinoma in a Fourteen-year-old Girl with Graves’ Disease2014

    • Author(s)
      Kojima-Ishii K, Ihara K, Ohkubo K, Matsuo T, Toda N, Yamashita H, Kono S, Hara T
    • Journal Title

      Clinical Pediatric Endocrinology

      Volume: 23 Issue: 2 Pages: 59-64

    • DOI

      10.1297/cpe.23.59

    • NAID

      130004853603

    • ISSN
      0918-5739, 1347-7358
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of p53 but not Rb in the cytoplasm of neurons and small vessels in an autopsy of a patient with Cockayne syndrome.2014

    • Author(s)
      Miyahara H, Itonaga T, Maeda T, Izumi T, Ihara K
    • Journal Title

      Neuropathology.

      Volume: in press Issue: 3 Pages: 266-272

    • DOI

      10.1111/neup.12183

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hyperinsulinemic hypoglycemia of infancy in Sotos syndrome.2013

    • Author(s)
      Matsuo T, Ihara K, Ochiai M, Kinjo T, Yoshikawa Y, Kojima-Ishii K, Noda M, Mizumoto H, Misaki M, Minagawa K, Tominaga K, Hara T
    • Journal Title

      Am J Med Genet A

      Volume: 161A(1) Issue: 1 Pages: 34-37

    • DOI

      10.1002/ajmg.a.35657

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Coagulopathy in patients with late-onset ornithine transcarbamylase deficiency in remission state: A previously unrecognized complication2013

    • Author(s)
      Ihara K
    • Journal Title

      Pediatrics

      Volume: 131 Issue: 1 Pages: e327-e330

    • DOI

      10.1542/peds.2012-0030

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Left ventricular efficiency after ligation of patent ductus arteriosus for premature infants.2013

    • Author(s)
      Nagata H, Ihara K, Yamamura K, Tanoue Y, Shiokawa Y, Tominaga R, Hara T
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 146(6): Issue: 6 Pages: 1353-8

    • DOI

      10.1016/j.jtcvs.2013.02.019

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fatigue and quality of life in citrin deficiency during adaptation and compensation stage.2013

    • Author(s)
      Okano Y, Kobayashi K, Ihara K, Ito T, Yoshino M, Watanabe Y, Kaji S, Ohura T, Nagao M, Noguchi A, Mushiake S, Hohashi N, Hashimoto-Tamaoki T
    • Journal Title

      Mol Genet Metab.

      Volume: 109(1) Issue: 1 Pages: 9-13

    • DOI

      10.1016/j.ymgme.2013.01.020

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hypothalamic pituitary complications in Kabuki syndrome.2013

    • Author(s)
      Ito N, Ihara K, Tsutsumi Y, Miyake N, Matsumoto N, Hara T
    • Journal Title

      Pituitary

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Two neonatal cholestasis patients with mutations in the SRD5B1(AKR1D1) gene: diagnosis and bile acid profiles during chenodeoxycholic acid treatment.2013

    • Author(s)
      Seki Y, Mizuochi T, Kimura A, Takahashi T, Ohtake A, Hayashi S, Morimura T, Ohno Y, Hoshina T, Ihara K, Takei H, Nittono H, Kurosawa T, Homma K, Hasegawa T, Matsuishi T
    • Journal Title

      J Inherit Metab Dis

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic susceptibility to Kawasaki disease: Analysis of pattern recognition receptor genes.2012

    • Author(s)
      Onoyama S, Ihara K, Yamaguchi Y, Ikeda K, Yamaguchi K, Yamamura K, Hoshina T, Mizuno Y, Hara T
    • Journal Title

      Hum Immunol

      Volume: 73 Issue: 6 Pages: 654-60

    • DOI

      10.1016/j.humimm.2012.03.011

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Histo-blood group gene polymorphisms as potential genetic modifiers of the development of coronary artery lesions in patients with Kawasaki disease.2012

    • Author(s)
      Yamamura K, Ihara K, Ikeda K, Nagata H, Mizuno Y, Hara T
    • Journal Title

      Int J Immunogenet

      Volume: 39 Issue: 1 Pages: 119-25

    • DOI

      10.1016/j.ijcard.2012.03.021

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] NKRP1A+ γδ and αβ T cells are preferentially induced in patients with Salmonella infection.2012

    • Author(s)
      Hoshina T
    • Journal Title

      Hum Immunol

      Volume: 73 Issue: 4 Pages: 623-628

    • DOI

      10.1111/j.1365-2265.2012.04390.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] HLA-class II and class I genotypes among Japanese children with Type 1A diabetes and their families2012

    • Author(s)
      Sugihara S
    • Journal Title

      Pediatric Diabetes

      Volume: 13 Issue: 1 Pages: 33

    • DOI

      10.1111/j.1399-5448.2011.00833.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 小児科診療のための臨床遺伝学と臨床カウンセリングの基礎知識2016

    • Author(s)
      井原健二
    • Organizer
      日本小児科学会佐賀地方会
    • Place of Presentation
      佐賀大学医学部臨床講堂(佐賀県佐賀市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 脂質代謝と成長ホルモン:免疫細胞を介した調節メカニズムの探究2015

    • Author(s)
      井原健二
    • Organizer
      宮崎代謝内分泌研究会
    • Place of Presentation
      宮崎大学医学部(宮崎県清武町)
    • Year and Date
      2015-03-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 日常診療に潜む稀少疾患-小児内分泌・代謝疾患を察知する-2014

    • Author(s)
      井原健二
    • Organizer
      第67回九州小児科学会
    • Place of Presentation
      大分県労働福祉会館(大分県大分市)
    • Year and Date
      2014-11-22 – 2014-11-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] SGA性低身長に対するGH治療による代謝・免疫学的影響の検討2014

    • Author(s)
      石井加奈子、井原健二、大久保一宏、松尾光通、戸田尚子、原 寿郎
    • Organizer
      第87回日本内分泌学会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 遅発型 Ornithine Transcarbamylase (OTC) 欠損症に潜在する凝固異常2013

    • Author(s)
      井原健二、芳野信、保科隆之、原田なをみ、石井加奈子、長谷川有紀、渡辺順子、山口清次、原寿郎
    • Organizer
      第116回日本小児科学会
    • Place of Presentation
      広島
    • Related Report
      2013 Research-status Report
  • [Presentation] 新生児一過性高インスリン性低血糖はSotos症候群の重要な臨床的特徴である2013

    • Author(s)
      井原 健二、松尾 光通、吉川 陽子、落合 正行、金城 唯宗、石井加奈子、原 寿郎、水本 洋、野田 麻里絵、富永 康仁、三﨑 真生子
    • Organizer
      第86回日本内分泌学会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] 日本人小児1型糖尿病の疾患感受性遺伝子の探求:ABO型とLewis型血液型抗原の関与2013

    • Author(s)
      井原健二、深野智華、戸田尚子、原寿郎、綾部匡之、深見真紀、杉原茂孝、緒方勤、雨宮伸
    • Organizer
      第47回日本小児内分泌学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 新生児一過性高インスリン性低血糖はSotos症候群の重要な臨床的特徴である2013

    • Author(s)
      井原 健二、松尾 光通、吉川 陽子、落合 正行、金城 唯宗、石井加奈子、原 寿郎、水本 洋、野田 麻里絵、富永 康仁、三﨑 真生子
    • Organizer
      第58回日本人類遺伝学会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] エコチル調査と小児内分泌・代謝疾患 胎児期および幼少期における環境と肥満、インスリン抵抗性、2型糖尿病の発生2012

    • Author(s)
      井原健二
    • Organizer
      第115回日本小児科学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] とっておきの症例:多腺性自己免疫症候群III型の母娘例2012

    • Author(s)
      井原健二
    • Organizer
      第46回日本小児内分泌学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 脂質代謝におけるSTAT5B遺伝子の役割2012

    • Author(s)
      井原健二
    • Organizer
      第26回 日本小児脂質研究会
    • Place of Presentation
      川越
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] SGA性低身長に対するGH治療による血液・免疫学的影響の検討2012

    • Author(s)
      石井加奈子、井原健二、牧村美佳、野崎高史、大久保一宏、松尾光通、原 寿郎
    • Organizer
      第115回日本小児科学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 成長ホルモン分泌不全における脂質代謝に関与する遺伝的背景因子の解析2012

    • Author(s)
      井原健二、牧村美佳、石井加奈子、大久保一宏、野崎高史、原寿郎、河野斉
    • Organizer
      第115回日本小児科学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] こどもの生活習慣病を予防する

    • Author(s)
      井原健二
    • Organizer
      第44回日本小児感染症学会総会・学術集会 市民公開講座
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 遺伝に関する基礎知識と遺伝カウンセリングについて

    • Author(s)
      井原健二
    • Organizer
      新型出生前診断の導入を考える:西南大学公開シンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 今日の治療指針2016年版 先天性甲状腺機能低下症2016

    • Author(s)
      井原健二
    • Publisher
      医学書院
    • Related Report
      2015 Research-status Report
  • [Book] 今日の小児治療指針:褐色細胞腫2015

    • Author(s)
      井原健二
    • Publisher
      医学書院
    • Related Report
      2015 Research-status Report
  • [Book] 乳児期以降の低血糖(分担),ワンランク上の小児内分泌疾患2013

    • Author(s)
      井原健二(分担)
    • Publisher
      総合医学社
    • Related Report
      2013 Research-status Report
  • [Book] Cushing症候群(分担) 今日の小児治療指針 第15版2012

    • Author(s)
      井原健二
    • Publisher
      医学書院
    • Related Report
      2012 Research-status Report
  • [Book] 糖原病(分担),最新ガイドライン準拠 小児科 診断・治療指針2012

    • Author(s)
      井原健二
    • Publisher
      中山書店
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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