Effect of insulin-like growth factor-I in intrauterine growth-restricted preterm infants.
| Project/Area Number |
24591611
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
Shoji Hiromichi 順天堂大学, 医学(系)研究科(研究院), 准教授 (30365621)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Toshiaki 順天堂大学, 医学部, 教授 (30260889)
OKUMURA Akihisa 順天堂大学, 医学部, 客員准教授 (60303624)
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 子宮内発育不全 / IGF-1 / 早産児 / 極低出生体重児 / IGF-I |
|---|
| Outline of Final Research Achievements |
Intrauterine growth restriction was induced by bilateral uterine artery ligation in pregnant rats. IUGR pups were divided into two groups injected daily with rhIGF-I (2mg/kg; IUGR/IGF-I) or saline (IUGR/physiologic saline solution (PSS)) from postnatal day (PND) 7 to 13. Maternal sham-operated pups injected with saline were used as controls (control). Mean bodyweight on PND3 and PND25 in the IUGR pups (IUGR/IGF-I and IUGR/PSS) was significantly lower than that of the control pups. Serum IGF-I and hepatic Igf-ir mRNA in the IUGR pups were significantly lower than those in the control pups. In the IUGR/IGF-I group, hepatic Igfbp3 mRNA and liver immunohistochemical staining were increased.
In a human study in preterm infants, IGF-I levels in SGA infants without EUGR were as high as those observed in AGA infants and were significantly different from those in SGA infants with EUGR at 4 and 8 weeks of age.
|
Report
(5 results)
Research Products
(6 results)
