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A study on biomarker of dementia of Lewy bodies with dopamine transporter imaging

Research Project

Project/Area Number 24591733
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionNippon Medical School

Principal Investigator

UEDA Satoshi  日本医科大学, 医学部, 講師 (80465294)

Co-Investigator(Kenkyū-buntansha) OKUBO Yoshiro  日本医科大学, 医学(系)研究科, 教授 (20213663)
TATENO Amane  日本医科大学, 医学部, 准教授 (50297917)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsDLB / DAT imaging / dopamine transportaer / レビー小体型認知症 / PETイメージング / ドパミントランスポーター / 国際研究者交流 / 国際情報交換
Outline of Final Research Achievements

It does not appear easy to correctly diagnose patients with dementia with Lewy bodies (DLB). Although there is no definite diagnostic biomarkers for DLB, dopamine transporter (DAT) imaging using PET is considered possibly usuful as one of the strong biomarkers.
DAT imaging was conducted for patients with depression or parkinsonism, which DLB often accompanies. DAT imaging made it very easy to diagnose DLB among depressive or parkinsonic patients. These findings suggest that DAT imaging using PET may be a clinically useful biomarker for DLB.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2015 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results) Book (3 results)

  • [Journal Article] ECT死亡例は発作により異型狭心症を毎回生じていた可能性2013

    • Author(s)
      上田諭、鈴木一正
    • Journal Title

      精神医学

      Volume: 55 Pages: 673-675

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful use of olanzapine for catatonia following delirium2012

    • Author(s)
      S.Ueda, J. Takeuchi, Y.Okubo
    • Journal Title

      Psychiatry and Clinical Neuroscience

      Volume: 66 Issue: 5 Pages: 465-465

    • DOI

      10.1111/j.1440-1819.2012.02368.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 初老期のセネストパチーと躁的要素―気分安定薬の有用性―2012

    • Author(s)
      上田諭、丸谷俊之、大久保善朗
    • Journal Title

      精神神経学雑誌

      Volume: 115 Pages: 127-138

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] パルス波では適切な刺激設定と発作評価が必要2012

    • Author(s)
      上田諭
    • Journal Title

      臨床精神医学

      Volume: 24 Pages: 118-126

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Delusions of Alzheimer's disease; due to brain lesions or psychological reasonns?2015

    • Author(s)
      Satoshi Ueda, Yoshiro Okubo
    • Organizer
      The 9th World Congress on Controversies in Neurology
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 自己肯定感を取り戻す精神療法―認知症に対する重要性2014

    • Author(s)
      上田諭
    • Organizer
      第110回日本精神神経学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-06-26 – 2014-06-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Improvement of behavioral and psychological symptoms of dementia with intervention for social psychology of “Kitwood Formula”: a case of Alzheimer’s disease2014

    • Author(s)
      Satoshi Ueda, Yoshiro Okubo
    • Organizer
      13th International Geneva/Springfield Stmposium on Advance in Alzheimer Thrapy
    • Place of Presentation
      Geneva, Swiss
    • Related Report
      2013 Research-status Report
  • [Presentation] NIDS (neuroleptic-induced deficit syndrome) in bipolar disorder with psychosis: three cases of prolonged treatment course2013

    • Author(s)
      Satoshi Ueda, Ataru Omori, Yoshiro Okubo et al.
    • Organizer
      13th International Forum of Mood and Anxiety Disordes
    • Place of Presentation
      Monte Carlo, Monaco
    • Related Report
      2013 Research-status Report
  • [Presentation] 病識の存在を認め、自己肯定感をもたらす―アルツハイマー型認知症に対する精神療法2013

    • Author(s)
      上田諭
    • Organizer
      第36回日本精神病理・精神療法学会
    • Place of Presentation
      京都市
    • Related Report
      2013 Research-status Report
  • [Presentation] 「症状」ではなく「生活」を診るAD診療―認知機能より「生きる張り合い」を求めて2013

    • Author(s)
      上田諭
    • Organizer
      第32回日本認知症学会
    • Place of Presentation
      長野県松本市
    • Related Report
      2013 Research-status Report
  • [Presentation] NIDS(Neuroleptic-induced deficit syndrome)がうつ病を統合失調症に見せる―長年誤審されていた中年男性症例2012

    • Author(s)
      上田諭、大久保善朗
    • Organizer
      第108回日本精神神経学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] NIDS(Neuroleptic-induced deficit syndrome) can make depression resemble schizophrenia2012

    • Author(s)
      S.Ueda, A.Omori, H.Fukuta, T.Kobayashi, Y,Okubo
    • Organizer
      World Psychiatric Association International Congress 2012
    • Place of Presentation
      チェコ・プラハ
    • Related Report
      2012 Research-status Report
  • [Book] 治さなくてよい認知症2014

    • Author(s)
      上田諭
    • Total Pages
      188
    • Publisher
      日本評論社
    • Related Report
      2013 Research-status Report
  • [Book] 統合失調症2013

    • Author(s)
      上田諭(分担執筆)
    • Publisher
      医学書院
    • Related Report
      2012 Research-status Report
  • [Book] 妄想の臨床2013

    • Author(s)
      上田諭(分担執筆)
    • Publisher
      新興医学出版社
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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