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Prevention for formation and enlargement of cerebral aneurysm by polyphenol

Research Project

Project/Area Number 24592111
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cerebral neurosurgery
Research InstitutionHirosaki University

Principal Investigator

OHKUMA Hiroki  弘前大学, 医学(系)研究科(研究院), 教授 (40211099)

Co-Investigator(Kenkyū-buntansha) ASANO Kenichirou  弘前大学, 医学(系)研究科(研究院), 准教授 (90312496)
SHIMAMURA Norihito  弘前大学, 医学(系)研究科(研究院), 講師 (40312491)
MUNAKATA Akira  弘前大学, 医学部附属病院, 医員 (80400159)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords脳動脈瘤 / ポリフェノール
Outline of Final Research Achievements

The aim of this study was to investigate the efficacy of polyphenol for prevention of formation and/or enlargement of cerebral aneurysm. Cerebral aneurysm was induced by ligation of bilateral carotid artery in rabbit. In treatment group, 40mg/kg/day of apple polyphenol was orally administered. In non-treatment group, arterial wall became thin, the number of smooth muscle cells decreased, and cerebral aneurysm was seen in 75% rabbit 3 months after bilateral carotid artery ligation. In treatment group, these findings were suppressed, and aneurysm formation was seen in 13% rabbit. I order to investigate the preventative effect of polyphenol, apple polyphenol was administered for 3 months from 3 months after bilateral carotid artery ligation. The size of cerebral aneurysm in the treatment group was significantly smaller than the non-treatment group. These results suggest that polyphenol has preventative effects on formation and enlargement of cerebral aneurysm.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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