Effect of micro-RNA on tachyarrhythmia in septic condition.

• Project/Area Number: 24592362
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Aichi Medical University
• Principal Investigator: HATAKEYAMA Noboru 愛知医科大学, 医学部, 教授 (70251907)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 敗血症 / 頻脈性不整脈 / 全身性炎症反応症候群 / 心房筋

Outline of Final Research Achievements

Effect of micro-RNA on channel remodeling in atrial cardiac myocyte on atrial fibrillation in septic condition was investigated. Septic condition was induced by the injection of lipopolysaccharide, and in this model, expression of L-type calcium channel was inhibited, but expression of delayed rectified potassium channel was enhanced. At the same time, expression of inducible nitric oxide was enhanced. In the blood, micro particles that contain micro RNA were observed, but direct relationship between micro-RNA and channel remodeling could not find. It was suspected that channel remodeling in septic condition might be a direct effect of inflammatory cytokines.

Research Products

• [Journal Article] Alert cell strategy: mechanisms of inflammatory response and organ protection. (2014)
  • Author(s): Hatakeyama N, Matsuda N
  • Journal Title: Curr Pharm Des. Volume: 20 Issue: 36 Pages: 5766-5778
  • DOI: 10.2174/138161282036140912122809
  • Peer Reviewed
• [Journal Article] Mechanisms of Inflammatory Response and Organ Dysfunction: Organ-Protective Strategy by Anesthetics. (2014)
  • Author(s): Hatakeyama N, Matsuda N
  • Journal Title: Curr Pharm Des Volume: in press
  • Peer Reviewed
• [Presentation] 炎症と不整脈 (2015)
  • Author(s): 畠山 登
  • Organizer: 日本循環制御医学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-06-04 – 2015-06-05
  • Invited
• [Presentation] MODULATION OF EXPRESSION AND FUNCTION OF ION CHANNELS IN ATRIAL MYOCYTE FROM SEPTIC GUINEA PIG (2012)
  • Author(s): N.Hatakeyama
  • Organizer: ESICM LIVES 2012 25th Annual Congress
  • Place of Presentation: Lisbon
• [Presentation] 心血管系におけるmicroRNAの役割と今後の展望 (2012)
  • Author(s): 畠山 登
  • Organizer: 日本心臓血管麻酔学会第17回学術大会
  • Place of Presentation: 仙台
  • Invited