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Prevention of cancer by oral care inhibiting the production of acetaldehyde

Research Project

Project/Area Number 24593154
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionOkayama University

Principal Investigator

YOKOI AYA  岡山大学, 大学病院, 医員 (00612649)

Co-Investigator(Kenkyū-buntansha) YAMANAKA Reiko  岡山大学, 大学病院, 助教 (00379760)
MORITA Manabu  岡山大学, 医歯(薬)学総合研究科, 教授 (40157904)
YAMASAKI Yutaka  北海道大学, 歯学研究科(研究院), 教授 (90250464)
KASHIWAZAKI Haruhiko  北海道大学, 大学病院, 講師 (10344516)
HATA Hironobu  北海道大学, 歯学研究科(研究院), 助教 (70450830)
Co-Investigator(Renkei-kenkyūsha) TOMOFUJI Takaaki  岡山大学, 医歯(薬)学総合研究科, 准教授 (80335629)
TAMAKI Naofumi  徳島大学, 大学院医歯薬学研究部, 准教授 (20335615)
EKUNI Daisuke  岡山大学, 大学病院, 講師 (70346443)
MARUYAMA Takayuki  岡山大学, 大学病院, 助教 (30580253)
SOGA Yoshihiko  岡山大学, 大学病院, 准教授 (70509489)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords口腔ケア / アセトアルデヒド / 舌苔 / 上部消化管癌 / 予防 / 頭頚部癌
Outline of Final Research Achievements

The aim of this study was to investigate the relationship between acetaldehyde concentration in mouth air and tongue coating volume in healthy volunteers. Acetaldehyde concentration in participants with a tongue coating score of 3 was significantly higher than those with a score of 1. After removing tongue coating, acetaldehyde concentration was significantly decreased.
Oral microflora on the tongue may be the main source of local production of acetaldehyde. Removing tongue coating may be a method inhibiting the production of acetaldehyde.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2015 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Relationship between acetaldehyde concentration in mouth air and tongue coating volume.2015

    • Author(s)
      Yokoi A, Maruyama T, Yamanaka R, Ekuni D, Tomofuji T, Kashiwazaki H, Yamazaki Y, Morita M
    • Journal Title

      Journal of Applied Oral Science

      Volume: 23 Issue: 1 Pages: 64-70

    • DOI

      10.1590/1678-775720140223

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Relationship between serum albumin concentration and periodontal condition in patients with head and neck cancer.2012

    • Author(s)
      Maruyama T, Yamanaka R, Yokoi A, Ekuni D,Tomofuji T, Mizukawa N, Onoda T, Eguchi M,Morita M.
    • Journal Title

      J Periodontol

      Volume: 83 Issue: 9 Pages: 1110-1115

    • DOI

      10.1902/jop.2011.110536

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Relationship Acetaldehyde Concentration In Mouth Air And Oral Condition2014

    • Author(s)
      Yokoi A, Maruyama T, Yamanaka R, Ekuni D, Tomofuji T, Morita M
    • Organizer
      IADR/PER congress 2014
    • Place of Presentation
      Dubrocnik, Croatia
    • Year and Date
      2014-09-10 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Relationship between acetaldehyde and candida tropicalis in HNC patients2013

    • Author(s)
      横井彩
    • Organizer
      World congress on preventive dentistry
    • Place of Presentation
      Budapest,Hungary
    • Related Report
      2013 Research-status Report
  • [Presentation] 頭頸部がんセンターにおける定期的な病棟往診の役割2012

    • Author(s)
      丸山 貴之, 志茂 加代子, 佐々木 禎子, 水谷 慎介, 児島 梓, 米田 俊樹, 町田 達哉, 横井 彩, 山中 玲子, 森田 学
    • Organizer
      第33回岡山歯学会総会・学術集会
    • Place of Presentation
      岡山
    • Related Report
      2012 Research-status Report
  • [Presentation] Removal of percutaneous endoscopic jejunostomy tube after wearing removable partial denture.2012

    • Author(s)
      Reiko Yamanaka, Mami Minakuchi, Kumiko Nawachi, Takayuki Maruyama, Yoshihiko Soga, Takuo Kuboki, Manabu Morita
    • Organizer
      the 10th International Conference of Asian Academy of Preventive Dentistry
    • Place of Presentation
      Ulaanbaatar, Mongolia
    • Related Report
      2012 Research-status Report
  • [Presentation] Relationship between Nutritional Status and Oral Condition in HNC Patients2012

    • Author(s)
      Maruyama T, Yamanaka R, Yokoi A, Ekuni D, Tomofuji T, Mizukawa N, Onoda T, Eguchi M, Morita M.
    • Organizer
      The International Association for Dental Research (IADR) 90th General Session
    • Place of Presentation
      Iguaçu Falls, Brazil
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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