Statistical development and application of countermeasures for space deconditioning
| Project/Area Number |
24620011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
宇宙生命学
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| Research Institution | Aichi Medical University |
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Principal Investigator |
IWASE SATOSHI 愛知医科大学, 医学部, 教授 (90184879)
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| Co-Investigator(Kenkyū-buntansha) |
Nishimura Naoki 愛知医科大学, 医学部, 講師 (40278362)
Inukai Yoko 愛知医科大学, 医学部, 講師 (10308950)
Sato Maki 愛知医科大学, 医学部, 助教 (60351102)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 人工重力 / 宇宙飛行デコンディショニング / G耐性 / 筋萎縮 / 骨粗鬆症 / 起立性低血圧 / 長期間臥床 / ヘッドダウンベッドレスト / 宇宙医学 / 微小重力 / 短腕式遠心機 / 心循環系デコンディショニング / 骨代謝異常 / ベッドレスト実験 / 人工重力負荷 / 運動負荷 / 宇宙酔い / 起立不耐性 / 骨粗そう症 / 自律神経 / 筋骨格系萎縮 / 骨塩量喪失 |
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| Outline of Final Research Achievements |
We assessed whether space flight deconditioning, induced by microgravity, can be prevented and ameliorated by centrifuge-induced artificial gravity with exercise. Old type centrifuge of 4 m in diameter was remodeled to 2.8 m type centrifuge, enabled to be loaded on board in space station. The first remodeled type made the subjects sit on a rotating chair, however, this was revealed not to load the enough G to the heart. We secondly remodeled the rotating chair lying down on the back with their legs elevated to provide the enough G to the heart. Using the second remodeled type, we performed bedrest study, and found the effectiveness in G-tolerance, bone metabolism, myatrophy, etc. We concluded that the short arm centrifuge of 2.8 m in diameter was effective in prevention and amelioration of space flight deconditioning.
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Report
(5 results)
Research Products
(81 results)
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[Journal Article] Respiratory mosulation of human autonomic function on Earth.2016
Author(s)
Eckberg DL, Cooke WH, Eiedrich A, Biaggioni I, Buckey JC Jr, Pawelczyk JA, Ertle AC, Cox JF, Kuusela TA, Tahvanainen KU, Mano T, Iwase s, Baisch FJ, levine BD, Adams-Huet B, Robertson D, Blomqvist CG
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Journal Title
Journal of Physiology May 29
Volume: Epub
Issue: 19
Pages: 5611-5627
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Respiratory modulation of human autonomic function. Long-term neuroplasticity in space.2016
Author(s)
Eckberg DL, Diedrich A, Cooke WH, Biaggioni I, Buckey JC Jr. Pawelczyk JA, Ertle AC, Cox JF, Kuusela TA, Tahvanainen KU, Mano T, Iwase s, Baisch FJ, Levine BD, Adams-Huet B, Robertson D, Blomqvist CG.
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Journal Title
Journal of Physiology May 29
Volume: Epub
Issue: 19
Pages: 5629-5646
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A comparison of head-out mist bathing, with or without facial fanning, with head-out half-body low-water level bathing in humans-a pilot study2014
Author(s)
207. Iwase S, Kawahara Y, Nishimura N, Nishimura R, Miwa C, Kataoka Y, Kobayashi C, Suzuki T, Shigaraki M, Maeda Y, Takada H, Watanabe Y
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Journal Title
International Journal of Biometeology
Volume: 58
Issue: 5
Pages: 1-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Arterial pressure oscillation and muscle sympathetic nerve activity after 20 days of head-down bed rest.2013
Author(s)
Tanaka K, Nishimura N, Sato M, Kanikowska D, Shimizu Y, Inukai Y, Abe C, Iwata C, Morita H, Iwase S, Sugenoya J.
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Journal Title
Auton Neurosci
Volume: 177(2)
Issue: 2
Pages: 266-270
DOI
Related Report
Peer Reviewed
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[Journal Article] Using the moon as a high-fiedelity analogue environment to study biological and behavioral effects of long-duration space exploration.2012
Author(s)
199. Goswami N, Roma PG, DeBoever P, Clement G, Hargens AR, Loeppky JA, Evans JM, Stein TP, Blaber AP, Van Loon JJWA, Mano T, Iwase S, Reitz G, Hinghofer-Szalkay H G.
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Journal Title
Planetary and Space Science
Volume: 74
Pages: 111-120
Related Report
Peer Reviewed
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[Presentation] Seasonal changes in orthostatic tolerance in Parkinson's disease without autonomic failure.2015
Author(s)
Niimi Y, Hasegawa Y, Iwase S, Ieda t, Okada A, Yamana T, Yamagishi T, Mano K, Koike Y.
Organizer
International Society for Autonomic Neuroscience, Stresa 2015
Place of Presentation
Stressa Convention Center, Stressa Italy
Year and Date
2015-09-26
Related Report
Int'l Joint Research
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[Presentation] 123-ioflupane (DaTscan) revealed presynaptic nigrostriatal involvement in two elderly patients with pure autonomic failure.2015
Author(s)
Ieda T, Hirayama M, Yarita S, Iwasaki J, Kawai Y, Iwade N, Satake Y, Hamada K, Niimi Y, Iwase S, hasegawa Y, Takahashi A.
Organizer
International Society for Autonomic Neuroscience, Stresa 2015
Place of Presentation
Stressa Convention Center, Stressa Italy
Year and Date
2015-09-26
Related Report
Int'l Joint Research
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[Presentation] Artificial Gravity and Exercise2014
Author(s)
Satoshi Iwase
Organizer
Life in Space for Life on Earth, 35th Annual International Gravitational Physiology Meeting, 13th European Life Sciences symposium, 1st Aging in space symposium
Place of Presentation
University of Waterloo, Waterloo, Ontario, Canada, 200, University Avenue west, Waterloo, Ontario, Canada, N21 3G1, +1 519 888 4567
Year and Date
2014-06-16 – 2014-06-20
Related Report
Invited
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[Presentation] Effect of Artificial Gravity as the Countermeasures for Space Flight Deconditioning in Humans2014
Author(s)
S. Iwase, N. Nishimura, K. Tanaka, T. Mano
Organizer
Life in Space for Life on Earth, 35th Annual International Gravitational Physiology Meeting, 13th European Life Sciences symposium, 1st Aging in space symposium
Place of Presentation
University of Waterloo, Waterloo, Ontario, Canada, 200, University Avenue west, Waterloo, Ontario, Canada, N21 3G1, +1 519 888 4567
Year and Date
2014-06-16 – 2014-06-20
Related Report
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[Presentation] Progress of AGREE project: multilateral project on the effectiveness of artificial gravity with ergometric exercise.2012
Author(s)
Satoshi Iwase, Naoki Nishimura, Junichi Sugenoya, William Paloski, Laurence Young, Jack J.W.A. van Loon, Floris Wuyts, Gilles Clément, Jörn Rittweger, Rupert Gerzer,et al
Organizer
Denver Conference of ISS Development and Research
Place of Presentation
Denver, Colorado, USA
Related Report
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[Presentation] Progress of AGREE project2012
Author(s)
Satoshi Iwase, Naoki Nishimura, Junichi Sugenoya, William Paloski, Laurence Young, Jack J.W.A. van Loon, Floris Wuyts, Gilles Clément, Jörn Rittweger, Rupert Gerzer, et al.
Organizer
63rd International Astronautical Congress, Naples
Place of Presentation
Napoli, Italy
Related Report
Invited
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[Book] Guidelines for Standardization of Bed Rest Studies in the Spaceflight Context2014
Author(s)
Angerer O, Bareille MP, Boese A, Cromwell R, Frings-Meuthen P, Gerzer R, Godard B, Graef P, Heer M, Iwase S, Kourtidou-Papadeli C, Kozlovskaya I, Larina I, Li YH, McPhee J, Meck J, Mukai C, Rittweger J
Publisher
International Academy of Astronautics
Related Report
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