Quality control mechanisms for aberrant mRNA that emerges under stress conditions
| Project/Area Number |
24770131
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Nagoya City University |
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Principal Investigator |
HOSODA Nao 名古屋市立大学, 薬学研究科(研究院), 講師 (40438198)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | mRNA分解 / 翻訳 / ストレス / ストレス応答 / 核酸 |
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| Research Abstract |
We further confirmed quality control mechanisms for non-stop mRNA using mammalian cells. The non-stop mRNA is degraded in a translation-dependent manner. The decay requires exosome complex. In addition, we examined decay of in vitro synthesized mRNA, which is an example of aberrant mRNA. The decay does not depend on poly(A) tail shortening. The exosome functions in the mRNA decay as in the non-stop mRNA decay.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] Biological Role of the Two Overlapping Poly(A)-binding Protein Interacting Motifs 2 (PAM2) of a Eukaryotic Releasing Factor, eRF3 in mRNA decay2012
Author(s)
Masanori Osawa, Nao Hosoda, Tamiji Nakanishi, Naoyuki Uchida, Tomomi Kimura, Shunsuke Imai, Asako Machiyama, Toshiaki Katada, Shin-ichi Hoshino, and Ichio Shimada
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Journal Title
RNA
Volume: 18
Pages: 1957-1967
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