| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We previously generated transgenic mice that express mutant form of mitochondrial DNA (mtDNA) polymerase in their forebrain neurons. These mice showed bipolar disorder-like phenotype and accumulated deleted mitochondrial DNA in the several brain regions including the paraventricular nucleus of the thalamus (PVT). To clarify the characteristic features of the PVT, we performed gene expression analysis of the PVT and other brain regions which have been suggested the involvement in bipolar disorder by using microarray. As a result, we found that the genes related to mitochondrial function, especially oxidative phosphorylation, and cholesterol biosynthesis were highly expressed in the PVT compared with the other brain regions.
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