Experimental Study on antitumor effect of AMPK activated regent on oral squamous cell carcinoma
Project/Area Number |
24792193
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Kanazawa University |
Principal Investigator |
KATO Koroku 金沢大学, 大学病院, 講師 (30444201)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 癌 / 細胞・組織 / AMPK / アポトーシス / 浸潤 / 口腔癌 / 浸潤・転移 |
Research Abstract |
Apoptosis induction with AMPK activating agents was examined using an apoptosis detection kit, demonstrating marked apoptosis induction at 24 hours after administration.The mRNA expressions of cell growth factors were examined with AMPK activating agents, demonstrating the decreased expressions of mTOR and Akt1, Akt3 and the increased expressions of p53 and p21. Their protein expressions were also examined, demonstrating the decreased expression of phospho-mTOR over time and the increased expressions of p53 and p21. The effects of AMPK activating agents on invasion were examined, demonstrating significant inhibitory effects on invasion in treated groups. The expressions of MMPs were examined, demonstrating the decreased expression of pro-MMP-2. Furthermore, the mRNA expression of ARK5 decreased over time.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Loss of claudin-7 is a negative factor for invasion and metastasis in oral squamous cell carcinoma2013
Author(s)
Yoshizawa K, Nozaki S, Kato A, Hirai M, Yanase M, Yoshimoto T, Kimura I, Sugiura S, Okamune A, Kitahara H, Noguchi N, Kato K, Ueki K, Kawashiri S
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Journal Title
Oncology Reports
Volume: 29
Pages: 445-450
Related Report
Peer Reviewed
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[Journal Article] Loss of claudin-7 is a negative prognostic factor for invasion andmetastasis in oral squamous cell carcinoma2013
Author(s)
Yoshizawa K., Nozaki S., Kato A., Hirai M., Yanase M., Yoshimoto T., KimuraI., Sugiura .S, Okamune A., Kitahara H., Noguchi N., Kato K., Ueki K., Kawashiri S
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Journal Title
Oncology Report
Volume: 29
Issue: 2
Pages: 445-450
DOI
Related Report
Peer Reviewed
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[Presentation] AMPK 活性化薬剤による口腔扁平上皮癌細胞の抗腫瘍効果の検討2012
Author(s)
加藤広禄, 野口夏代, 吉澤邦夫, 北原寛子, 岡宗絢子, 杉浦史郎, 木村依世, 八木瑞希, 加藤阿希, 平井真理子, 川尻秀一
Organizer
第57回 日本口腔外科学会総会・学術大会
Place of Presentation
パシフィコ横浜 (神奈川)
Related Report
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