Evaluation of the significance of prenylation on the physiological function of flavonoids
| Project/Area Number |
25292075
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TERAO Junji 徳島大学, 大学院医歯薬学研究部, 教授 (60093275)
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| Co-Investigator(Kenkyū-buntansha) |
MUKAI Rie 徳島大学, 大学院医歯薬学研究部, 助教 (90547978)
中村 俊之 静岡県立大学, 食品栄養科学部, 助教 (90706988)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 食品機能 / フラボノイド / プレニル化 / 抗酸化酵素 / 血管内皮 / 血管内皮細胞 / ヘムオキシゲナーゼー１ / カベオリン-1 / カベオラ / Nrf2 / MAPK経路 / 生体利用性 / 抱合体代謝 |
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| Outline of Final Research Achievements |
This study was aimed to evaluate the effect of prenylation on the functionality of flavonoids from the viewpoint of structure-activity relationship. The compounds used were 6-prenylquercetin (6-PQ), 5-PQ and 8-PQ. We found that hydrophobicity is changed depending on the positon of prenyl group in the flavonoid structure. 6-PQ with the highest hydrophobicity showed the highest induction of heme oxygenase-1 in accordance with the highest efficiency of cellular uptake in human blood endothelial cells. The result that quercetin modulated the vascular function of caveolin-1 in the cells may indicate that caveolin-1 and caveolae are potential targets for the action of prenylated flavonoids
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Preventive effect of dietary quercetin on disuse muscle atrophy by targeting mitochondria in denervated mice.2016
Author(s)
Mukai, R., Matsui N., Fujikura Y., Matsumoto N., Hou D-X, Kanzaki N., Shibata H., Horikawa M., Iwasa K., Hirasaka K., Nikawa T., Terao J.
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Journal Title
Jouranl of Nutritional Biochemistry
Volume: 31
Pages: 67-76
Related Report
Peer Reviewed / Acknowledgement Compliant
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