Biological characteristic and genetic background of pediatric thyroid carcinoma

• Project/Area Number: 25293087
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: University of Yamanashi
• Principal Investigator: KATOH Ryohei 山梨大学, 総合研究部, 教授 (30152755)
• Co-Investigator(Kenkyū-buntansha): KONDO Tetsuo 山梨大学, 総合研究部, 准教授 (30334858) ; NAKAZAWA Tadao 山梨大学, 総合研究部, 准教授 (10345704) ; OISHI Naoki 山梨大学, 総合研究部, 助教 (90623661)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2013: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
• Keywords: 甲状腺がん / 小児 / 放射線 / 病理 / 遺伝子

Outline of Final Research Achievements

We enrolled 81 pediatric patients aged <20 years who received surgery for PTC. The control group included 83 cases of adult PTC from patients >20 years old. Compared with adult PTCs, pediatric PTCs exhibited larger tumor size (p=0.001), more frequent 10 lymph node metastasis (p<0.001) and less classical PTC histology (p=0.001). The prevalence of BRAFV600E mutation in pediatric PTCs was 37% and significantly lower than that（82% ）in adults (p<0.001). The BRAF mutation was positively associated with classical PTC histology (p=0.001) but independent from clinical aggressiveness. TERT promoter mutations were identified in 13% of adults and in none of the pediatric PTCs (p=0.001). In 15 the adult PTCs, In conclusion, we found that pediatric PTCs are characterized by more advanced clinicopathological features, lower frequency of BRAFV600E mutation and complete absence of TERT promoter mutation. The lack of TERT promoter mutation may explain the favorable prognosis of pediatric PTCs.

Research Products

• [Journal Article] Immunohistochemical Detection of NRASQ61R Protein in Follicular-patterned Thyroid Tumors. (2016)
  • Author(s): Oishi N, Kondo T, Vuong HG, Nakazawa T, Mochizuki K, Kasai K, Inoue T, Tahara I, Hirokawa M, Miyauchi A, Katoh R.
  • Journal Title: Hum Pathol. Epub ahead of print Volume: - Pages: 51-57
  • DOI: 10.1016/j.humpath.2016.02.008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Spindle cell oncocytoma of adenohypophysis: Report of a case and immunohistochemical review of literature. (2016)
  • Author(s): Vuong HG, Kondo T, Tran TM, Oishi N, Nakazawa T, Mochizuki K, Inoue T, Kasai K, Tahara I, Jieying W, Katoh R.
  • Journal Title: Pathol Res Pract. Volume: 212 Issue: 3 Pages: 222-225
  • DOI: 10.1016/j.prp.2015.07.014
  • Peer Reviewed / Open Access
• [Journal Article] Branchial Cleft-Like Cysts Involving 3 Different Organs: Thyroid Gland, Thymus, and Parotid Gland. (2015)
  • Author(s): Nakazawa T, Kondo T, Oishi N, Tahara I, Kasai K, Inoue T, Mochizuki K, Katoh R.
  • Journal Title: Medicine Volume: 94 Issue: 42 Pages: e1758-e1758
  • DOI: 10.1097/md.0000000000001758
  • Peer Reviewed / Open Access
• [Journal Article] High prevalence of the MYD88 mutation in testicular lymphoma: Immunohistochemical and genetic analyses. (2015)
  • Author(s): Oishi N, Kondo T, Nakazawa T, Mochizuki K, Tanioka F, Oyama T, Yamamoto T, Iizuka J, Tanabe K, Shibata N, Kirito K, Katoh R.
  • Journal Title: Pathol Int. Volume: 65 Issue: 10 Pages: 528-535
  • DOI: 10.1111/pin.12336
  • Peer Reviewed / Open Access
• [Journal Article] Subcutaneous porocarcinoma clinically presenting as a soft tissue tumor (2015)
  • Author(s): Nakazawa T, Kondo T, Sato E, Motosugi U, Niu D, Mochizuki K, Kawasaki T, Yamane T, Katoh R
  • Journal Title: J Cutan Pathol Volume: 42 Issue: 11 Pages: 897-902
  • DOI: 10.1111/cup.12576
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of nuclear membrane proteins in normal, hyperplastic, and neoplastic thyroid epithelial cells. (2015)
  • Author(s): Wang J, Kondo T, Yamane T, Nakazawa T, Oish N, Mochizuki K, Katoh R
  • Journal Title: Virchows Arch. Volume: 467(4) Issue: 4 Pages: 427-436
  • DOI: 10.1007/s00428-015-1816-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Gastric adenocarcinoma of pyloric gland type with high-grade malignancy. (2014)
  • Author(s): Mochizuki K, Kondo T, Tahara I, Inoue T, Kasai K, Oishi N, Nakazawa T, Komiyama A, Katoh R.
  • Journal Title: Pathol Int. Volume: 65(3) Issue: 3 Pages: 148-50
  • DOI: 10.1111/pin.12241
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Epithelial Splicing Regulatory Protein 1 (ESRP1) and 2 (ESRP2) Suppress Cancer Cell Motility via Different Mechanisms (2014)
  • Author(s): Hiroki Ishii, Masao Saitoh, Kei Sakamoto, Tetsuo Kondo, Ryohei Katoh, Shota Tanaka, Mitsuyoshi Motizuki, Keisuke Masuyama, Keiji Miyazawa
  • Journal Title: The journal of biological chemistry Volume: 289(40) Issue: 40 Pages: 27386-99
  • DOI: 10.1074/jbc.m114.589432
  • Peer Reviewed / Open Access
• [Journal Article] The expression of groups IIE and V phospholipase A2 is associated with an increased expression of osteogenic molecules in human calcified aortic valves. (2014)
  • Author(s): Suzuki K, Takahashi S, Watanabe K, Fujioka D, Nakamura T, Obata JE, Kawabata K, Katoh R, Matsumoto M, Kugiyama K.
  • Journal Title: J Atheroscler Thromb Volume: 21(12) Pages: 1308-25
  • NAID: 130004677974
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: case report and literature review. (2014)
  • Author(s): Oishi N, Kondo T, Nakazawa T, Mochizuki K, Kasai K, Inoue T, Yamamoto T, Watanabe H, Hatsushika K, Masuyama K, Katoh R
  • Journal Title: Pathol Res Pract Volume: 210(12) Issue: 12 Pages: 1142-5
  • DOI: 10.1016/j.prp.2014.04.020
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Localized Langerhans cell histiocytosis of the thymus with BRAF V600E mutation: a case report with immunohistochemical and genetic analyses. (2014)
  • Author(s): Oishi N, Kondo T, Mochizuki K, Inoue T, Kasai K, Nakazawa T, Mitsumori T, Katoh R
  • Journal Title: Hum Pathol. Volume: 45(6) Issue: 6 Pages: 1302-5
  • DOI: 10.1016/j.humpath.2013.12.018
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Primary Cervical Leiomyoma with Remarkable Calcification and Ossification (2014)
  • Author(s): Yamanishi T, Sakamoto K, Watanabe H, Yonaga T, Oishi N, Katoh R, Masuyama K
  • Journal Title: Case Rep Otolaryngol. Volume: 2014 Pages: 1-4
  • DOI: 10.1155/2014/896275
  • Peer Reviewed
• [Journal Article] Well-differentiated neuroendocrine tumour of the breast showing peculiar endovascular spread. (2014)
  • Author(s): Kawasaki T, Gianni B, Caterina M, Isabella C, Daniele,Luca M , Hinata M , Furuya K, Nakagomi H, Oyama T ,Tsunoda H, Sugai T, Katoh R, Anna S
  • Journal Title: Histopathology Volume: 4 Issue: 4 Pages: 597-600
  • DOI: 10.1111/his.12276
  • Peer Reviewed
• [Journal Article] Immature squamous metaplasia (focal atypical epithelial hyperplasia) of the pancreatic duct-immunohistochemical distinction from intraductal carcinoma. (2013)
  • Author(s): Mochizuki K, Kondo T, Oishi N, Kawasaki T, Nakazawa T, Yamane T, Katoh R.
  • Journal Title: Histopathology Volume: 63(3) Issue: 3 Pages: 343-350
  • DOI: 10.1111/his.12180
  • Peer Reviewed
• [Presentation] Cytopathologic and genetic features of pediatric thyroid carcinoma (2015)
  • Author(s): 加藤良平
  • Organizer: 39th Europian congress of cytology, Millan
  • Place of Presentation: ミラノコンベンションセンター(イタリア、ミラノ)
  • Year and Date: 2015-09-20
  • Int'l Joint Research / Invited
• [Presentation] 甲状腺癌の組織・細胞分類の改定点-甲状腺癌取扱い規約第7版に向けて- (2015)
  • Author(s): 加藤良平
  • Organizer: 第56回日本臨床細胞学会総会(春期大会)
  • Place of Presentation: くにびきメッセ・松江テレサ(島根県、松江市)
  • Year and Date: 2015-06-12
  • Invited
• [Presentation] 新しい(第7版)甲状腺取扱い規約のOverview (2015)
  • Author(s): 加藤良平
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県、名古屋市)
  • Year and Date: 2015-04-30
  • Invited
• [Presentation] 甲状腺癌における低分化成分の臨床的意義 (2015)
  • Author(s): 近藤哲夫
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県、名古屋市)
  • Year and Date: 2015-04-30
• [Presentation] 小児・若年甲状腺乳頭癌におけるBRAFV600E変異とTERTプロモーター変異の解析 (2015)
  • Author(s): 大石直輝
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県、名古屋市)
  • Year and Date: 2015-04-30
• [Presentation] 小児若年甲状腺癌のおけるBRAF V600E およびTERT promoter mutation の解析 (2014)
  • Author(s): 大石直輝
  • Organizer: 第32回内分泌代謝学サマーセミナー
  • Place of Presentation: 富士レークホテル(山梨県・南都留郡)
  • Year and Date: 2014-07-10 – 2014-07-12
• [Presentation] 甲状腺癌の機能形態学的攻究 -甲状腺濾胞の成り立ちから腫瘍まで- (2014)
  • Author(s): 加藤良平
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島国際会議場(広島県・広島市)
  • Year and Date: 2014-04-24 – 2014-04-26
  • Invited
• [Presentation] 低分化 (充実、索状、島状構造)成分を伴う甲状腺癌の臨床病理学的検討 (2014)
  • Author(s): 近藤哲夫
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島国際会議場(広島県・広島市)
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 多発甲状腺乳頭癌の発生機序 (2014)
  • Author(s): 中澤匡男
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島国際会議場(広島県・広島市)
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 小児・若年者に発生する甲状腺癌の解析 (2014)
  • Author(s): 大石直輝
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島国際会議場(広島県・広島市)
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 日本と諸外国における甲状腺癌の組織・細胞診断と臨床的対応(治療)における違い (2013)
  • Author(s): 加藤 良平
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌(北海道札幌市)
• [Presentation] Putative anti-tumor properties of TTF- in thyroid carcinogenesis (2013)
  • Author(s): 近藤 哲夫、中澤 匡男、大石 直輝、望月 邦夫、川崎 朋範、山根 徹、加藤 良平
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌(北海道札幌市)
• [Presentation] アミオダロン関連甲状腺中毒症の1例 (2013)
  • Author(s): 中澤 匡男、近藤 哲夫、大石 直輝、望月 邦夫、川崎 朋範、山根 徹、加藤 良平
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌(北海道札幌市)
• [Presentation] Cytology of Solid Variant of Papillary Thyroid Carcinoma (2013)
  • Author(s): 加藤 良平
  • Organizer: 第18回国際臨床細胞学会
  • Place of Presentation: パリコンベンションセンター、フランス、パリ
  • Invited
• [Presentation] Classification of Thyroid Cancers according to Molecular Changes and its Application for Therapy. (2013)
  • Author(s): 加藤 良平
  • Organizer: The 8th APSMI Annual Meeting 2013
  • Place of Presentation: The Aetas Bangkok Hotel, タイ、バンコク
• [Presentation] Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: Morphological, Immunohistochemical, and Molecular Aspects (2013)
  • Author(s): 加藤 良平
  • Organizer: The 8th Asia Pacific IAP congress
  • Place of Presentation: Busan Exhibition & Convention Center, 韓国、Busan
• [Book] 解明病理学 第5版 病気のメカニズムを解く 第18章 内分泌. 標準病理学 . (2015)
  • Author(s): 加藤良平 (青笹克之編)
  • Total Pages: 827
  • Publisher: 医学書院
• [Remarks] 山梨大学 研究者総覧 加藤良平
  • URL: http://erdb.yamanashi.ac.jp/rdb/A_DispDetail.Scholar