Development of statistical method for case-cohort design when measurements of interests are known to be missing

• Project/Area Number: 25330039
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Statistical science
• Research Institution: Shiga University (2016); Oita University (2013-2015)
• Principal Investigator: Izumi Shizue 滋賀大学, データサイエンス教育研究センター, 教授 (70344413)
• Co-Investigator(Kenkyū-buntansha): 玉腰 暁子 北海道大学, 医学研究科, 教授 (90236737) ; 伊藤 陽一 北海道大学, 医学研究科, 准教授 (10334236) ; 野間 久史 統計数理研究所, データ科学研究系, 准教授 (70633486)
• Co-Investigator(Renkei-kenkyūsha): TAKEUCHI AYANO 慶應義塾大学, 医学部, 専任講師 (80511196) ; Cologne John 放射線影響研究所, 統計部, 研究員 (50344411)
• Research Collaborator: SUENAGA SATOSHI ; NAGATA DAIKI
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 医薬生物 / ゲノム統計解析 / ビッグデータ活用 / ゲノム疫学

Outline of Final Research Achievements

In the case-cohort study, costly and laborious research can be greatly saved by measuring expensive genome information only from selected subjects, not the entire cohort. However, since data observed from the target frequently includes missing values, data analysis becomes difficult. In this study, we developed a novel theoretical framework for case-cohort studies when measurements of interests are known to be missing. We also examined the application of the proposed method to large-scale genomic epidemiological studies. From results verified by numerical experiments, when the outcomes of the majority of the subjects in the cohort are missing, the sub-cohort extraction or data analysis performed by the traditional method leads bias in the effects of the interesting variable.

Research Products

• [Journal Article] A global goodness-of-fit test for linear structural mean models (2017)
  • Author(s): Taguri, M., Izumi, S.
  • Journal Title: Behaviormetrika Volume: 44 Issue: 1 Pages: 253-262
  • DOI: 10.1007/s41237-016-0003-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Erratum to: A global goodness-of-fit test for linear structural mean models (2017)
  • Author(s): Taguri, M., Izumi, S.
  • Journal Title: Behaviormetrika Volume: 44 Issue: 1 Pages: 263-263
  • DOI: 10.1007/s41237-016-0012-6
  • Open Access
• [Journal Article] Prenatal Exposure to Perfluoroalkyl Acids and Prevalence of Infectious Diseases up to 4 Years of Age (2017)
  • Author(s): Goudarzi H., Miyashita C, Okada E., Kashino I., Chen C.-J., Ito S., Araki A., Kobayashi S., Matsuura H., Kishi R.
  • Journal Title: Environment International Volume: - Pages: 124-132
  • DOI: 10.1016/j.envint.2016.05.020
  • NAID: 120006649165
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Logistic regression model for survival time analysis using time-varying coefficients (2016)
  • Author(s): Satoh K, Tonda T, Izumi S
  • Journal Title: American Journal of Mathematical and Management Sciences Volume: 35 Issue: 4 Pages: 353-360
  • DOI: 10.1080/01966324.2016.1215945
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 広島平和宣言における単語出現頻度に基づく広島の平和観の経時変化について (2016)
  • Author(s): 冨田哲治，佐藤健一，和泉志津恵
  • Journal Title: 長崎医学雑誌 Volume: 91 Pages: 176-179
  • Peer Reviewed
• [Journal Article] Interaction between a single exposure and age in cohort-based hazard rate models impacted the statistical distribution of age at onset (2016)
  • Author(s): Izumi, S., Sakata, R., Yamada, M., Cologne J.
  • Journal Title: Journal of Clinical Epidemiology Volume: 71 Pages: 43-50
  • DOI: 10.1016/j.jclinepi.2015.10.004
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Comprehensive Assessment of Impaired Peripheral and Coronary Artery Endothelial Function in Smokers Using Brachial Artery Ultrasound and Oxygen-15-labeled Water PET (2015)
  • Author(s): Noriki Ochi, Keiichiro Yoshinaga,Yoichi M. Ito, Yuuki Tomiyama, Mamiko Inoue, Mutsumi Nishida, Osamu Manabe, Hitoshi Shibuya , Chikara Shimizu, Eriko Suzuki, Satoshi Fujii, Chietsugu Katoh, Nagara Tamaki.
  • Journal Title: Journal of Cardiology Volume: in press Issue: 4 Pages: 316-323
  • DOI: 10.1016/j.jjcc.2015.10.006
  • Peer Reviewed / Open Access
• [Journal Article] Association between shift work and the risk of death from biliary tract cancer in Japanese men (2015)
  • Author(s): Lin, Y., Nishiyama, T., Kurosawa, M., Tamakoshi, A., Kubo, T., Fujino, Y., Kikuchi, S.; JACC Study Group
  • Journal Title: BMC Cancer Volume: 15 Issue: 1 Pages: 757-757
  • DOI: 10.1186/s12885-015-1722-y
  • NAID: 120005758417
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] <i>Helicobacter Pylori</i> Infection and Risk of Death From Cardiovascular Disease Among the Japanese Population: a Nested Case-Control Study within the JACC Study (2015)
  • Author(s): Lin, Y., Obata, Y., Kikuchi, S., Tamakoshi, A., Iso, H.; JACC Study Group
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Issue: 11 Pages: 1207-1213
  • DOI: 10.5551/jat.27987
  • NAID: 130005106113
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Japan Environment and Children&rsquo;s Study (JECS): A Preliminary Report on Selected Characteristics of Approximately 10 000 Pregnant Women Recruited During the First Year of the Study (2015)
  • Author(s): Michikawa T, Nitta H, Nakayama SF, Ono M, Yonemoto J, Tamura K, Suda E, Ito H, Takeuchi A, Kawamoto T, for the Japan Environment and Children’s Study Group
  • Journal Title: Journal of Epidemiology Volume: 25 Issue: 6 Pages: 452-458
  • DOI: 10.2188/jea.JE20140186
  • NAID: 130005074463
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access
• [Journal Article] 経時的に観測されたテキストデータに対する変化係数モデルに基づく統計的な分類方法と視覚化について (2015)
  • Author(s): 和泉志津恵，佐藤健一，川野徳幸
  • Journal Title: 計算機統計学 Volume: 28
  • NAID: 130005631732
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Simultaneous analysis of the gene expression profiles of cancer and stromal cells in endometrial cancer. (2014)
  • Author(s): Iguchi Y, Ito YM, Kataoka F, Nomura H, Tanaka H, Chiyoda T, Hashimoto S, Nishimura S, Takano M, Yamagami W, Susumu N, Aoki D, Tsuda H.
  • Journal Title: Genes, Chromosomes & Cancer Volume: 53 Issue: 9 Pages: 725-37
  • DOI: 10.1002/gcc.22182
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prognostic factors for survival in patients with high-grade meningioma and recurrence-risk stratification for application of radiotherapy. (2014)
  • Author(s): Yamaguchi, S., Terasaka, S., Kobayashi, H., Asaoka, K., Motegi, H., Nishihara, H., Kanno, H., Onimaru, R., Ito, Y.M., Shirato, H., Houkin, K.
  • Journal Title: PLoS One Volume: 9 Issue: 5 Pages: e97108-e97108
  • DOI: 10.1371/journal.pone.0097108
  • Peer Reviewed / Open Access
• [Journal Article] Rationale and study design of the Japan environment and children’s study (JECS) (2014)
  • Author(s): Kawamoto T, Nitta H, Murata K, Toda E, Tsukamoto N, Hasegawa M, Yamagata Z, Kayama F, Kshi R, Ohya Y, Saito H, Sago H, Okuyama M, Ogata T, Yokoya S, Koresawa Y, Shibata Y, Nakayama S, Michikawa T, Takeuchi A, Saitoh H
  • Journal Title: BMC Public Health Volume: 14 Issue: 1 Pages: 25-25
  • DOI: 10.1186/1471-2458-14-25
  • Peer Reviewed / Open Access
• [Journal Article] Serum interleukin-6 associated with hepatocellular carcinoma risk: a nested case-control study (2014)
  • Author(s): Waka Ohishi, John B. Cologne, Saeko Fujiwara, Gen Suzuki, Tomonori Hayashi, Yasuharu Niwa, Masazumi Akahoshi, Keiko Ueda, Masataka Tsuge, Kazuaki Chayama
  • Journal Title: International Journal of Cancer Volume: 134巻 Issue: 1 Pages: 154-163
  • DOI: 10.1002/ijc.28337
  • Peer Reviewed / Open Access
• [Journal Article] 観察研究におけるバイアスの感度解析 (2014)
  • Author(s): 竹内文乃, 野間 久史
  • Journal Title: 統計数理 Volume: 62 Pages: 77-92
  • NAID: 120006020824
  • Peer Reviewed / Open Access
• [Journal Article] Current practice for the prevention and treatment of missing data in confirmatory clinical trials: A survey of Japan-based and foreign-based pharmaceutical manufacturers in Japan (2014)
  • Author(s): Tanaka, S., Fukinbara, S., Tsuchiya, S., Suganami, H., Ito, Y.M.
  • Journal Title: Therapeutic Innovation & Regulatory Science Volume: - Issue: 6 Pages: 717-723
  • DOI: 10.1177/2168479014530974
  • Peer Reviewed
• [Journal Article] 位置情報を用いた疫学研究とその統計的方法 (2014)
  • Author(s): 高橋邦彦, 和泉志津恵, 竹内文乃
  • Journal Title: 統計数理 Volume: 62
  • NAID: 120006020806
  • Peer Reviewed
• [Journal Article] ケースコホート研究の理論と統計手法 (2014)
  • Author(s): 野間久史
  • Journal Title: 統計数理 Volume: 62
  • NAID: 120006020815
  • Peer Reviewed
• [Presentation] 生存時間データにおけるロジスティック回帰モデルを用いたオッズ比の推測 (2017)
  • Author(s): 佐藤健一，冨田哲治，和泉志津恵
  • Organizer: 第27回日本疫学会学術総会
  • Place of Presentation: ベルクラシック甲府（Yamanashi, Japan）
  • Year and Date: 2017-01-25
• [Presentation] Big Data and Health- From Data Science Viewpoint - (2017)
  • Author(s): Izumi, S.
  • Organizer: International Workshop on Bioethics Governance 2017
  • Place of Presentation: 滋賀大学大津サテライトキャンパス（Shiga, Japan）
  • Int'l Joint Research / Invited
• [Presentation] Estimating the effects of exposure in a case-cohort design of Hokkaido Cohort study when some binary outcomes of interests are known to be missing (2016)
  • Author(s): Izumi, S., Sato, T., Ito, Y.M.
  • Organizer: XXVIIIth International Biometric Conference （IBC2016)（国際学会）
  • Place of Presentation: Victoria Convention Centre. (Victoria, Canada)
  • Year and Date: 2016-07-10
  • Int'l Joint Research
• [Presentation] How does the statistical interaction between a single point exposure and attained age imply the shape of age-at-onset distribution? (2015)
  • Author(s): Izumi, S., Cologne, J.
  • Organizer: East Asia Regional Biometric Conference (EAR-BC) 2015
  • Place of Presentation: Kyushu University. (Fukuoka, Japan)
  • Year and Date: 2015-12-20
  • Int'l Joint Research
• [Presentation] Construct a simultaneous confidence interval for linear time varying coefficients in Cox proportional hazard model (2015)
  • Author(s): Izumi, S., Tonda, T., Satoh K.
  • Organizer: Joint Statistical Meetings (JSM) 2015
  • Place of Presentation: Washington State Convention Center. (Seattle, U.S.A.)
  • Year and Date: 2015-08-08
  • Int'l Joint Research
• [Presentation] Innovative mathematical modelling for the effects of chronic exposure to radiation on cancer risk (2015)
  • Author(s): Izumi, S., Ohtaki, M., Aihara, K.
  • Organizer: 15th International Congress of Radiation Research (ICRR2015)
  • Place of Presentation: Kyoto International Conference Center. (Kyoto, Japan)
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Interaction between exposure and age in cohort-based risk models: effect modification or age dependence of the excess rate? (2015)
  • Author(s): Cologne, J., Izumi, S., Sakata, R., Yamada, M.
  • Organizer: 応用統計学会2015 年度年会
  • Place of Presentation: 京都大学医学部創立百周年記念施設芝蘭会館（京都府京都市）
  • Year and Date: 2015-03-14
• [Presentation] Comparing the effects of duration of chronic exposure to radioactive fallout on the cancer risk with those of a single point exposure, based on a simulation study. (2015)
  • Author(s): Izumi, S., Nagata, D., Aihara, K., Ohtaki, M.
  • Organizer: The 5th International Symposium of RIRBM, Hiroshima University. -Biological Effects of Low Dose Radiation-
  • Place of Presentation: Hiroshima University. (Hiroshima, Japan)
  • Year and Date: 2015-03-02 – 2015-03-03
• [Presentation] Statistical inference for linear varying coefficients in Cox proportional hazard model. (2014)
  • Author(s): Izumi, S., Tonda, T., Satoh, K.
  • Organizer: Kyoto International Conference on Modern Statistics in the 21st Century
  • Place of Presentation: Kyoto International Conference Center（Kyoto, Japan）
  • Year and Date: 2014-11-17 – 2014-11-18
• [Presentation] 発がん数理モデルに基づく曝露の期間を考慮した過剰相対リスクの推定について (2014)
  • Author(s): 和泉志津恵
  • Organizer: 京都生物統計セミナー
  • Place of Presentation: 京都大学大学院医学研究科（京都府京都市）
  • Year and Date: 2014-11-11
  • Invited
• [Presentation] Study design and methods based on the two stage sampling (2014)
  • Author(s): Izumi, S.
  • Organizer: 科研費シンポジウム「多様な分野における統計科学の教育・理論・応用の新展開」
  • Place of Presentation: 新潟大学駅南キャンパスときめいと講義室A（新潟県新潟市）
  • Year and Date: 2014-10-24 – 2014-10-26
• [Presentation] 臨床研究における生物統計学の最近の進展 - 研究デザイン，解析方法，モデル選択- (2014)
  • Author(s): 和泉志津恵
  • Organizer: 第13回久留米大学バイオ統計学フォーラム
  • Place of Presentation: JR博多シティ大会議室(福岡県福岡市)
  • Year and Date: 2014-09-26
  • Invited
• [Presentation] 線形構造平均モデルにおける適合性検定についての検討 (2014)
  • Author(s): 和泉志津恵, 田栗正隆
  • Organizer: 2014年度統計関連学会連合大会
  • Place of Presentation: 東京大学(東京都文京区)
  • Year and Date: 2014-09-13 – 2014-09-16
• [Presentation] Comparison of sampling schemes for a case-cohort design in Hokkaido cohort study when some outcomes of interests are known to be missing. (2014)
  • Author(s): Ito, Y.M., Izumi, S.
  • Organizer: The XXVII International Biometric Conference (IBC2014)
  • Place of Presentation: Firenze Fiera (Firenze, Florence, Italy)
• [Presentation] A goodness-of-fit test for linear structural mean models. (2014)
  • Author(s): Taguri, M., Izumi, S.
  • Organizer: The XXVII International Biometric Conference (IBC2014)
  • Place of Presentation: Firenze Fiera (Firenze, Florence, Italy)
• [Presentation] A new approach for statistical classification and visualization for longitudinal text data. (2014)
  • Author(s): Izumi, S., Satoh, K.
  • Organizer: The XXVII International Biometric Conference (IBC2014)
  • Place of Presentation: Firenze Fiera (Firenze, Florence, Italy)
• [Presentation] Innovative mathematical modelling for the effects of chronic exposure to radiation on cancer risk. (2014)
  • Author(s): Izumi, S., Ohtaki M., Aihara, K.
  • Organizer: The XXVII International Biometric Conference (IBC2014)
  • Place of Presentation: Firenze Fiera (Firenze, Florence, Italy)
• [Presentation] 2段階ケース・コホート研究における標本サイズの設計 (2014)
  • Author(s): 和泉志津恵, 永田大貴, 伊藤陽一
  • Organizer: 2014年度日本計量生物学会年会
  • Place of Presentation: 統計数理研究所（東京都立川市）
• [Presentation] 2段階ケース・コントロール研究における検出力の算出とその評価 (2014)
  • Author(s): 永田大貴, 和泉志津恵, 末永聡史
  • Organizer: 2014年度日本計量生物学会年会
  • Place of Presentation: 統計数理研究所（東京都立川市）
• [Presentation] 疫学研究における新しい研究デザインと解析 - nested case-control study, case-cohort studyを中心として - (2014)
  • Author(s): 和泉志津恵
  • Organizer: 北海道大学病院 高度先進医療支援センター 講演会
  • Place of Presentation: 北海道大学医学研究科（札幌市北区）
  • Invited
• [Presentation] 経時的テキストデータにおける出現パターンの抽出と分類 (2013)
  • Author(s): 和泉志津恵，佐藤健一，松浦陽子, 川野徳幸
  • Organizer: 2013年度統計関連学会連合大会
  • Place of Presentation: 大阪大学（大阪府豊中市）
• [Presentation] 放射線への連続曝露の場合の多段階発がん数理モデルの構築と超過リスクの定量的評価 (2013)
  • Author(s): 和泉志津恵，大瀧 慈，合原一幸
  • Organizer: 2013年度統計関連学会連合大会
  • Place of Presentation: 大阪大学（大阪府豊中市）
• [Presentation] ケースコホート研究の統計解析：2段階ケースコントロール研究との等価性と漸近有効な推定方式 (2013)
  • Author(s): 野間久史，田中司朗
  • Organizer: 日本行動計量学会第41回大会
  • Place of Presentation: 東邦大学（千葉県船橋市）
• [Presentation] Some examples of the treatment of missing data in investigator-initiated clinical trials. (2013)
  • Author(s): Ito, Y.M.
  • Organizer: Joint Conference of the Fifth Annual International Symposium on the Evaluation of Clinical Trials (Methodologies and Applications) and the Fourth East Asia Regional Biometric Conference 2013
  • Place of Presentation: Renmin University of China (Beijing, China)
  • Invited
• [Presentation] Multiple imputation analysis of nested case-control and case-cohort studies. (2013)
  • Author(s): Noma, H., Tanaka, S., Tanaka, S., Izumi, S.
  • Organizer: The 46th Society for Epidemiologic Research (SER) Annual Meeting
  • Place of Presentation: Boston Park Plaza Hotel (Boston, Massachusetts, U.S.A.)
• [Presentation] Nested Case-Control Design：バイオマーカを用いた分子疫学研究の標本数の設計 (2013)
  • Author(s): 和泉志津恵
  • Organizer: SAS統計手法研究部会
  • Place of Presentation: 北海道大学医学研究科（札幌市北区）
  • Invited
• [Presentation] Case-Cohort Design：調査・実験のコストと労力を節減するための新しい臨床研究・疫学研究のデザイン (2013)
  • Author(s): 野間久史
  • Organizer: SAS統計手法研究部会
  • Place of Presentation: 北海道大学医学研究科（札幌市北区）
  • Invited
• [Presentation] 欠測データに対する解析手法の概説 (2013)
  • Author(s): 伊藤陽一
  • Organizer: 2013年度日本計量生物学会年会・特別セッション
  • Place of Presentation: パルセいいざか（福島県福島市）
  • Invited