| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Outline of Final Research Achievements |
The present study demonstrated that in D-galactose aging model mice long-term administration of melatonin attenuated the age-related deficit in learning and memory as observed in naturally-aged mice. In both mice, melatonin attenuated the accumulation of oxidative stress in the brain and age-related morphological changes in the neurons. Comprehensive analysis of the gene expression in cerebral cortex revealed that expression levels of approximately 80 genes were clearly changed during natural aging, and that these changes were attenuated by long-term melatonin administration. Further study using D-galactose aging model mice will contribute to elucidate the mechanisms to explain anti-aging effects of melatonin on learning and memory.
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