Pharmacological potential of curcumin analog targeting KSRP, a regulator of miRNA
| Project/Area Number |
25430147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor therapeutics
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| Research Institution | Akita University |
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Principal Investigator |
Shibata Hiroyuki 秋田大学, 医学(系)研究科(研究院), 教授 (50260071)
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| Co-Investigator(Kenkyū-buntansha) |
IWABUCHI Yoshiharu 東北大学, 大学院薬学研究科, 教授 (20211766)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | クルクミン / mRNA / miRNA / KSRP / microRNA / メッセンジャーRNA（mRNA） / マイクロRNA（miRNA） / 大腸がん / 悪性リンパ腫 / 血管内皮細胞 / 腫瘍血管新生 |
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| Outline of Final Research Achievements |
Effects on mRNA and miRNA by curcumin analogs, GO-Y030 and GO-Y078, were examined. BCL-2, c-Myc and p53 were included in the affected transcripts by GO-Y030 among 41,058 transcripts in colorectal cancer cell line. Among 2,669 species of miRNAs in colorectal cancer cell line, 28 species and 11 species of miRNAs were up-regulated by GO-Y030 and GO-Y078, respectively. In endothelial cells, 470 species of mRNAs were up-regulated and 243 species were down-regulated. As for miRNA, has-miR-19b-3p was up-regulated in endothelial cells by GO-Y030, and 5 species of miRNAs were down-regulated by GO-Y078. KSRP contribution to the regulation of mRNA or miRNA expression was not elucidated at this present.
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Report
(4 results)
Research Products
(8 results)
