Creation of novel terpenoids from biosynthetic study on sesquarterpene
| Project/Area Number |
25450149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Niigata University |
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Principal Investigator |
Sato Tsutomu 新潟大学, 自然科学系, 准教授 (80334655)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIHASHI Masahiro 京都大学, 理学研究科, 助教 (10397581)
SHINADA Tetsuro 大阪市立大学, 理学研究科, 教授 (30271513)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | テルペン / テルペノイド / イソプレノイド / 生合成 |
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| Outline of Final Research Achievements |
Genome mining and analysis of multifunction of enzyme found novel terpenes. Onoceroid synthase was first identified. In addition, enzymatic synthesis of ambrein was succeeded. Search for novel type of terpene synthase from Mycobacterium and analysis of catalytic mechanism of novel enzyme were also steadily performed.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Biosynthesis of sesterterpene, head-to-tail triterpene, and sesquarterpene in Bacillus clausii: Identification of multifunctional enzymes and analysis of isoprenoid metabolites2015
Author(s)
Ueda, D., Yamaga, H., Murakami, M., Totsuka, Y., Shinada, T., Sato, T.
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Journal Title
ChemBiolChem
Volume: 16
Issue: 9
Pages: 1710-1714
DOI
Related Report
Peer Reviewed
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