| Project/Area Number |
25460444
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Fukuoka University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Shotaro 岩手医科大学, 医学部, 准教授 (10243932)
石塚 賢治 鹿児島大学, 医学部, 教授 (10441742)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ISHITSUKA Kenji 鹿児島大学, 医学部, 教授 (10441742)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | enteropathy / T-cell lymphoma / C-MET / C-MYC / FISH / IEL / BCL2 / 消化管 / 腸管症 / Ｔ細胞リンパ腫 / c-Met / c-Myc / Bcl2 |
|---|
| Outline of Final Research Achievements |
Twenty-six Japanese cases of type II enteropathy-associated T-cell lymphoma (EATL) were examined. Intramucosal tumor cell spread and a zone of neoplastic intraepithelial lymphocytes (IELs) neighboring the main tumors were detected in 20 (91%) and 17 (77%) of 22 cases, respectively. Outside of the IEL zone, enteropathy with reactive small IELs and villous atrophy was detected in 11 cases (50%). Lymphoma cells expressed C-MET, p-MEK1/2, C-MYC and BCL-2 in 18 (78%), 21 (91%), 11 (42%) and 19 (73%) cases, respectively. FISH revealed chromosomal loci 7q31 (C-MET) and 8q24 (C-MYC) were amplified in 11 (65%) and 12 (71%) of 17 cases, respectively. Gain of 7q31 and C-MET expression were significantly higher in type II cases than those with peripheral CD8-positive T-cell or CD56-positive NK-cell lymphoma (P<0.01). Enteropathy partly presents near the IEL zone, and C-MET-MAPK pathway and C-MYC-BCL2-mediated cell survival may play important roles in lymphomagenesis in type II EATL.
|
