| Project/Area Number |
25460456
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ITAKURA Masayuki 島根大学, 医学部, 講師 (60223070)
HYAKUDOMI Miki 島根大学, 医学部, 助教 (40758471)
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| Research Collaborator |
YOSHIDA Manabu
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | NAC-1 / 乳癌 / 予後 / 臨床病理学的因子 / NAC-1 タンパク / Her2 / ホルモンレセプター / 核グレード / Ki-67 / リンパ節 |
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| Outline of Final Research Achievements |
Breast cancer is the most common malignant tumor in the female population in Japan, but personalized medicine has greatly improved the treatment of breast cancer. Pathological diagnosis has recently played an important role in personalized medicine, and further contribution of pathology is expected. We reported in 2012 that low expression of nucleus accumbens-1 (NAC-1) protein was correlated with poor prognosis of the pancreatic carcinoma patients. Thus, we tried to clarify the relationship between NAC-1 expression and breast carcinoma patients’ prognosis. Our immunohistochemical result showed that low NAC-1 expression tended to have worse prognosis, but the difference was not statistically significant. However, we feel that improvement of the method of immunohistochemistry and image analysis by the software could change the result with significant difference between high and low expression groups, and we would like to continue the experiment further to get better results.
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