| Project/Area Number |
25460541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Kitasato University (2014-2015)
University of Miyazaki (2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKI Shigenobu 高知大学, 医歯学系, 准教授 (00190439)
UCHIYAMA Jumpei 麻布大学, 獣医学部, 講師 (20574619)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ボツリヌス菌 / 人畜共通感染症 / ボツリヌス毒素遺伝子 / バクテリオファージ / 水平伝播 / ファージ変換 / ゲノム解析 / プロテオーム解析 |
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| Outline of Final Research Achievements |
Because Clostridium botulinum types C and D produce botulinum neurotoxin, causing serious symptom botulism, they are recognized as severe pathogen you should prevent spreading in food and animal industries. The botulinum neurotoxin genes are coded on the prophage genomes, and so inhibition of lateral gene transfer mediated by bacteriophage (phage) can be one of the preventions for the disease. Thus, we investigated the adsorption mechanism of C. botulinum type C neurotoxin-converting phage, phage c-st on the genetic point. Based on the comparative genomics and identification of phage virion genes, we got at a speculation that several genes associated with phage adsorption. We are in advanced studies of the findings.
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